Abstract
Since the fundamental research of de Castro (1926) and of Heymans and Bouckaert (1930), the carotid body has been considered to be a peripheral chemoreceptor which transduces changes in arterial Po2 and arterial PCO2/PH into nerve signals. These signals predominantly regulate ventilation via the respiratory center and thus help to control the arterial blood gas level. However other organs such as the heart and the kidneys can also be influenced by nerve signals from the carotid body (Daly and Scott, 1958; Körner, 1963). Recently it has been found that the carotid body seems to be involved in very common diseases such as hypertension (Honig et al., 1981; Trzebski et al., 1982) as well as in sudden infant death syndrome (Naeye et al., 1976). The transducing process enabling the chemoreceptor to respond to changes in blood gases is unknown. If one regards the different cell types in the carotid body tissue as a complex of cells which collaborate in the chemoreceptive process, it can be postulated that there exists a Po2 or PCO2/PH dependent transmitter release from these cells which excites nerve fibres connected to these cells (Hayashida et al., 1981). It is our intention, to support this idea with our measurements of the tissue Po2, extracellular Ca2+ activity and cyclic AMP content during hypoxia and hypercapnia in the cat carotid body in vitro.
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© 1984 Plenum Press, New York
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Delpiano, M.A., Acker, H. (1984). O2 Chemoreception of the Cat Carotid Body in vitro . In: Lübbers, D.W., Acker, H., Leniger-Follert, E., Goldstrick, T.K. (eds) Oxygen Transport to Tissue-V. Advances in Experimental Medicine and Biology, vol 169. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-1188-1_63
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DOI: https://doi.org/10.1007/978-1-4684-1188-1_63
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