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Endocytosis and the Regulation of Cell Signaling, Cell Adhesion, and Epithelial to Mesenchymal Transition in Cancer

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Vesicle Trafficking in Cancer

Abstract

Endosomes play key roles in the control and execution of such diverse and spatially restricted processes as cell signaling, epithelial to mesenchymal transitions as well as cell adhesion and migration. The endocytosis of growth factor receptors and adhesion molecules, such as cadherins and integrins, is coming into focus as a major mechanism in the regulation of cellular processes that govern cell growth, differentiation, survival, and motility. Subversion of these pathways accompanies disease progression, especially cancer. We suggest that endosomes are multifunctional dynamic platforms on which unique sets of molecular components are assembled and sorted to adapt to different environmental and cellular cues. A better understanding of how endosomes can function as conduits for the acquisition of oncogenic phenotypes will lead to more specific therapeutic approaches to combat cancer progression.

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Acknowledgements

The authors’ research programs are supported in part by NIH grants, CA115316 to CDS and GM074692 to GL.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Notre Dame, Notre Dame, IN, 46556-0369, USA

    Crislyn D’Souza-Schorey

  2. Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA

    Guangpu Li

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Correspondence to Crislyn D’Souza-Schorey .

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  1. Department of Biological Regulation, Candiotty Bldg, Hertzel St 1, Rehovot, 76100, Israel

    Yosef Yarden

  2. , Department of Biological Regulation, Weizmann Institute of Science, Hertzl Street 1, Rehovot, 76100, Israel

    Gabi Tarcic

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D’Souza-Schorey, C., Li, G. (2013). Endocytosis and the Regulation of Cell Signaling, Cell Adhesion, and Epithelial to Mesenchymal Transition in Cancer. In: Yarden, Y., Tarcic, G. (eds) Vesicle Trafficking in Cancer. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6528-7_6

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