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Map** Functional Alterations in the CNS With [14C]Deoxyglucose

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Handbook of Psychopharmacology

Abstract

The advent of the autoradiographic [14C]-2-deoxyglucose technique (Sokoloff et al., 1977) has provided neuroscientists with an enormously potent tool with which to investigate functional events within the central nervous system. Two simple premises provide the conceptual basis for this novel approach. First, the energy requirements of cerebral tissue are derived almost exclusively from the aerobic catabolism of glucose (Sokoloff, 1977; Siesjo, 1978). Second, functional activity within any region of the central nervous system is intimately and directly related to energy consumption within that region (see Kennedy et al., 1975; Sokoloff, 1977). Thus, the ability to determine the rate of glucose consumption simultaneously in all neuroanatomically defined regions of the CNS of conscious animals by the use of the 2-deoxyglucose technique has been widely utilized to provide new insight into CNS processes.

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  1. Wellcome Surgical Institute, University of Glasgow, Glasgow, G61 1QH, Scotland

    James McCulloch

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  1. Department of Pharmacology, University of Cambridge, UK

    Leslie L. Iversen  & Susan D. Iversen  & 

  2. Department of Neuroscience, Pharmacology and Psychiatry, The Johns Hopkins University School of Medicine, USA

    Solomon H. Snyder

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McCulloch, J. (1982). Map** Functional Alterations in the CNS With [14C]Deoxyglucose. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Handbook of Psychopharmacology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-3452-1_8

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