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Determination of N-nitro-, C-nitro-, and C-nitrous-type Compounds in Meat Products by d-SPE Extraction and Liquid Chromatography Coupled to Mass Spectrometry

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Chemical Food Contaminants Analysis

Part of the book series: Methods and Protocols in Food Science ((MPFS))

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Abstract

This method is intended for the extraction of 2-methyl-1,4-dinitropyrrol (DNMP), 1-nitro-2-methyl-3-amino pyrrole (NMAP), and ethylnitrolic acid (ENA) from meat products and analysis by reversed-phase liquid chromatography (with C18 as stationary phase) coupled to tandem mass spectrometry with electrospray ionization source (LC-ESI-MS/S). The analytes quantitation is performed by matrix-matched analytical curves and internal standard calibration with deuterated N-nitrosopyrrolidine (NPYR-d4).

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References

  1. Molognoni L, Motta GE, Daguer H, Lindner JDD (2020) Microbial biotransformation of N-nitro-, C-nitro-, and C-nitrous-type mutagens by Lactobacillus delbrueckii subsp. bulgaricus in meat products. Food Chem Toxicol 136:110964

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  2. Molognoni L, Daguer H, Motta GE, Merlo TC, Lindner JDD (2019) Interactions of preservatives in meat processing: formation of carcinogenic compounds, analytical methods, and inhibitory agents. Food Res Int 125:108608

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  3. Molognoni L, Daguer H, Hoff RB, Rodrigues J, Joussef AC, Lindner JDD (2020) Assessing the mutagens ethylnitrolic acid and 2-methyl-1,4-dinitro-pyrrole in meat products: sample preparation and simultaneous analysis by LC–MS/MS. J Chromatogr A 1609:460512

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Authors and Affiliations

  1. Federal Laboratory of Animal and Plant Health and Inspection - LFDA/RS, Ministry of Agriculture and Livestock - MAPA, São José, Brazil

    Luciano Molognoni & Rodrigo Hoff

  2. Ministério da Agricultura e Pecuária (MAPA), Laboratório Federal de Defesa Agropecuária, Setor Laboratorial Avançado em Santa Catarina (SLAV-SC/LFDA/RS), São José, SC, Brazil

    Heitor Daguer

Authors
  1. Luciano Molognoni
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  2. Heitor Daguer
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  3. Rodrigo Hoff
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Corresponding author

Correspondence to Luciano Molognoni .

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Editors and Affiliations

  1. Ministry of Agriculture, Livestock, and, Sao Jose, Brazil

    Rodrigo Hoff

  2. Ministry of Agriculture Livestock and Su, Federal Distsrict, Brazil

    Luciano Molognoni

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Molognoni, L., Daguer, H., Hoff, R. (2024). Determination of N-nitro-, C-nitro-, and C-nitrous-type Compounds in Meat Products by d-SPE Extraction and Liquid Chromatography Coupled to Mass Spectrometry. In: Hoff, R., Molognoni, L. (eds) Chemical Food Contaminants Analysis. Methods and Protocols in Food Science . Humana, New York, NY. https://doi.org/10.1007/978-1-0716-3806-4_17

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  • DOI: https://doi.org/10.1007/978-1-0716-3806-4_17

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-0716-3805-7

  • Online ISBN: 978-1-0716-3806-4

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