Summary
A group of thirteen newly synthesized potential herbicides, N-aryl-trichloroacetamides or 2-(chlorophenoxy)acyl derivatives, have been initially investigated by reversed phase (RP) TLC. The lipophilicity of the substances was described by retention factors in water, log kw, calculated from experimental RP TLC data, and by log P values calculated by use of software. Biological activity was examined by use of the BioArena system of TLC separation then (micro)biological detection. The potential role of formaldehyde (HCHO) in the toxic antibacterial action of substances against Pseu-domonas savastanoi pv. phaseolicola bacterial cells was investigated. The effect of HCHO capturers (L-arginine and reduced glutathione) and Cu2+ ions on the bioactivity and mechanism of toxicity of the substances was examined. It was established that HCHO and its potential reaction products (e.g. 1O2, O3) are crucial in the mechanism of action of these molecules. Correlations between the lipophilicity and bioactivity of the test compounds were also analyzed. It seems that hydrophobicity is not the decisive factor affecting the bioactivity of these substances.
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Janicka, M., Tyihák, E., Móricz, Á.M. et al. Crucial Role of Formaldehyde and its Reaction Products in the Antiproliferative Activity of Some Potential Pesticides. JPC-J Planar Chromat 21, 161–166 (2008). https://doi.org/10.1556/JPC.21.2008.3.1
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DOI: https://doi.org/10.1556/JPC.21.2008.3.1