Abstract
Background
Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparticle research is a representative example where click chemistry showed its promising potential. Challenging trials with nanoparticles has been reported based on click chemistry including copper-catalyzed cycloaddition, strain-promoted azide-alkyne cycloaddition, and inverse-demand Diels-Alder reaction.
Main body
Herein, we provide an update on recent application of click chemistry in nanoparticle research, particularly nanoparticle modification and its targeted delivery. In nanoparticle modification, click chemistry has been generally used to modify biological ligands after synthesizing nanoparticles without changing the function of nanoparticles. Also, click chemistry in vivo can enhance targeting ability of nanoparticles to disease site.
Conclusion
These applications in nanoparticle research were hard or impossible in case of traditional chemical reactions and demonstrating the great utility of click chemistry.
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Background
Convergence is one of the favorite words in recent research field. Recently, challenging combination of multiple techniques from different research area has been widely tried to overcome the current hurdles. Biomedical application of nanoparticles, so called nanomedicine, is the representative result of the combinational researches based on chemistry, biology, material science, pharmaceutics, and clinic [1]. Organic materials such as polymers or phospholipids can self-assemble into spherical nano-structure in aqueous solution resulting micelles or liposomes [2, 3]. Inorganic materials including gold, iron oxide, or silica can provide controlled growth at nanoscale, and more complicated structures like rod, star, sheet, tube, or porous sphere can be obtained [28]. These trials will provide further increased specificity or reaction rate of click reactions and help solving the problems. Considering that, we expect that the potential and utility of click chemistry in biomedical science will be even greater in future.
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Acknowledgements
This research was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant no. 2016R1C1B3013951).
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Basic Science Research Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant no. 2016R1C1B3013951).
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Yi, G., Son, J., Yoo, J. et al. Application of click chemistry in nanoparticle modification and its targeted delivery. Biomater Res 22, 13 (2018). https://doi.org/10.1186/s40824-018-0123-0
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DOI: https://doi.org/10.1186/s40824-018-0123-0