Background

Esophageal cancer (EC), one of the most lethal cancers, is the seventh common cancer type and the sixth leading cause of cancer-related death in the world [1]. In China, there will be approximately 346,600 people newly diagnosed and 323,600 people dying from EC in 2022 [

Availability of data and materials

Raw data can be accessed form GSE213565.

Abbreviations

ESCC:

Esophageal squamous cell carcinoma

Early ESCC:

Early Esophageal squamous cell carcinoma

WES:

Whole-exome sequencing

TMB:

Tumor mutational burden

MSI:

Microsatellite instability

CNV:

Copy number variation

GRN:

Gene regulation network

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Acknowledgements

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Funding

This research was funded by the Natural Science Foundation of Fujian Province of China, grant number 2019J01170 and the Natural Science Foundation of Gansu Province of China, grant number 21JR1RA021.

Author information

Author notes

  1. **g**g Zhao and ** Li

  2. Department of Integrative Oncology, Fudan University Shanghai Cancer Center, and Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai, China

    **g**g Zhao, **ya Jia, Qiaojuan Li, Hena Zhang, Shenglin Huang & Zhixiang Hu

  3. Department of Pediatric Medicine, Gansu Provincial People’s Hospital, Lanzhou City, , Gansu Province, China

    Jianjun Wang

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  1. **g**g Zhao
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Contributions

Cai** Li, Jianjun Wang, Zhixiang Hu and Shenglin Huang designed the study; Cai** Li collected the data and clinical information; **g**g Zhao, Hena Zhang performed the bioinformatics analysis; Qiaojuan Li conducted the experiments; **g**g Zhao, **ya Jia and Zhixiang Hu wrote and revised the manuscript. All authors have read and agreed to the published version of the manuscript.

Corresponding authors

Correspondence to Zhixiang Hu or Cai** Li.

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Ethics approval and consent to participate

The study was implemented in accordance with Declaration of Helsinki and relevant guidelines by the institutional ethics committee. The study was approved by Ethics Committee of Second Affiliated Hospital of Fujian Medical University (Approval-Number: 2020-246, 2020-05-22). All methods were carried out in accordance with relevant guidelines and regulations under the ethical approval. All patients gave their informed consents.

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Supplementary Information

Additional file 1:

 Figure S1. The 8p11.23 amplification impacted the transcriptome.

Additional file 2:

 Table S1. A summary of variations of early ESCC by WES.

Additional file 3:

 Table S2. The DEGs between tumor and normal.

Additional file 4:

 TableS3. Clinical data of the patients in this study. Table S4. TCGA samples used in the study. Table S5. Primers and RNA sequences used in this study.

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Zhao, J., Jia, X., Li, Q. et al. Genomic and transcriptional characterization of early esophageal squamous cell carcinoma. BMC Med Genomics 16, 153 (2023). https://doi.org/10.1186/s12920-023-01588-7

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