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Copper(II) and Zinc(II) Complexes with Heterocyclic Acid Anions and 3,5-Dimethylpyrazole: Synthesis, Structure, and Biological Properties

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Abstract

The reaction of copper(II) and zinc(II) acetates with 3-furancarboxylic (HFur) and 2-thiophenecarboxylic (HTph) acids with subsequent addition of 3,5-dimethylpyrazole (HDmpz) gave mononuclear complexes [M(L)2(HDmpz)2] (M = Cu(II), L = Fur– (I), Tph– (II); Zn(II), L = Fur– (III)). The structures of compounds I–III were determined by X-ray diffraction. According to X-ray diffraction data, I and II are isostructural: the central Cu(II) atom occurs in a square planar environment formed by two oxygen atoms of carboxylate anions and HDmpz nitrogen atoms; in III, the Zn atom is in the tetrahedral environment of two furoate anions and HDmpz molecules, thus forming the {MO2N2} groups. The complexes are additionally stabilized in the crystal by inter- (I and II) and intramolecular (III) hydrogen bonds. The biological activity of I–III was determined in relation to the non-pathogenic Mycolicibacterium smegmatis.

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ACKNOWLEDGMENTS

X-ray diffraction, IR spectroscopy, and C,H,N,S analysis were performed using equipment of the Center for Collective Use of Physical Investigation Methods of the Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, supported by the state assignment for the Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, in the field of fundamental research.

Funding

This study was supported by the Ministry of Education and Science of the Russian Federation within the framework of the state assignment for the Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences.

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Authors and Affiliations

  1. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia

    M. A. Uvarova, M. V. Novikova, D. E. Baravikov, F. M. Dolgushin, E. V. Fatushina, M. A. Kiskin, I. L. Eremenko & I. A. Lutsenko

  2. Moscow Institute of Physics and Technology, Moscow, Russia

    M. V. Novikova

  3. School no. 1553 named after Vernadsky, Moscow, Russia

    V. A. Eliseenkova

  4. Mendeleev University of Chemical Technology of Russia, Moscow, Russia

    D. E. Baravikov

  5. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia

    O. B. Bekker

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  1. M. A. Uvarova
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  2. M. V. Novikova
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  3. V. A. Eliseenkova
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  9. I. L. Eremenko
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  10. I. A. Lutsenko
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Correspondence to M. A. Uvarova.

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Translated by Z. Svitanko

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Uvarova, M.A., Novikova, M.V., Eliseenkova, V.A. et al. Copper(II) and Zinc(II) Complexes with Heterocyclic Acid Anions and 3,5-Dimethylpyrazole: Synthesis, Structure, and Biological Properties. Russ J Coord Chem 49, 680–687 (2023). https://doi.org/10.1134/S1070328423600419

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