Abstract
Acyclovir and valacyclovir are oxidized on a glassy carbon electrode (GCE) with immobilized reduced graphene oxide coated with a polyglycine film. We selected the conditions for forming a polymer film, reducing graphene oxide on the GCE, and recording the maximum catalytic current on the composite surface. A procedure was developed for the selective voltammetric determination of acyclovir and valacyclovir on an electrode with a reduced graphene oxide–polyglycine film composite. A method is proposed for the amperometric detection of guanine-based antiviral drugs with this modified electrode under the conditions of flow-injection analysis. The dependence of the analytical signal on the concentration of acyclovir and valacyclovir is linear up to 5 × 10–6 M in the static mode and up to 1 × 10–7 M in the flow-injection system. The developed voltammetric method for determining acyclovir and valacyclovir was tested in the analysis of pharmaceutical preparations.
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13 February 2023
An Erratum to this paper has been published: https://doi.org/10.1134/S1061934822380014
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Shaidarova, L.G., Gedmina, A.V., Poadnyak, A.A. et al. Selective Voltammetric and Flow-Injection Amperometric Determination of Acyclovir and Valacyclovir on an Electrode with a Reduced Graphene Oxide–Polyglycine Film Composite. J Anal Chem 77, 681–687 (2022). https://doi.org/10.1134/S1061934822060156
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DOI: https://doi.org/10.1134/S1061934822060156