A voltammetric method for determining acyclovir using a chemically modified electrode with catalytic properties was developed. The catalytic properties for acyclovir oxidation of glassy-carbon electrodes modified by inorganic films of Ru(III) hexachloroplatinate or hexacyanocobaltate were compared. The catalytic effect was manifested as a decreased potential and multiply increased oxidation current at the proposed film electrodes. The greatest catalytic effect was observed using an electrode with a film of Ru(III) hexachloroplatinate. The catalytic current depended linearly on the analyte concentration in the range from 0.5 μM to 5 mM. The proposed method was used to determine acyclovir in drugs.
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The work was supported financially by the Russian Foundation for Basic Research (Grants No. 12-03-97031 and 13-03-01101).
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 48, No. 11, pp. 37 – 43, November, 2014.
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Shaidarova, L.G., Gedmina, A.V., Zhaldak, E.R. et al. Voltammetric Determination of Acyclovir in Drugs Using an Electrode Modified by Ruthenium Hexachloroplatinate or Hexacyanocobaltate Film. Pharm Chem J 48, 747–752 (2015). https://doi.org/10.1007/s11094-015-1186-z
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DOI: https://doi.org/10.1007/s11094-015-1186-z