Abstract
Cigarette craving is a key contributor of nicotine addiction. Hypnotic aversion suggestions have been used to help smoking cessation and reduce smoking relapse rates but its neural basis is poorly understood. This study investigated the underlying neural basis of hypnosis treatment for nicotine addiction with resting state Electroencephalograph (EEG) coherence as the measure. The sample consisted of 42 male smokers. Cigarette craving was measured by the Tobacco Craving Questionnaire. The 8-minute resting state EEG was recorded in baseline state and after hypnotic induction in the hypnotic state. Then a smoking disgust suggestion was performed. A significant increase in EEG coherence in delta and theta frequency, and significant decrease in alpha and beta frequency, between the baseline and the hypnotic state was found, which may reflect alterations in consciousness after hypnotic induction. More importantly, the delta coherence between the right frontal region and the left posterior region predicted cigarette craving reduction after hypnotic aversion suggestions. This suggests that the functional connectivity between these regions plays an important role in reducing cigarette cravings via hypnotic aversion suggestions. Thus, these brain regions may serve as an important target to treat nicotine addiction, such as stimulating these brain regions via repetitive transcranial magnetic stimulation.
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Introduction
In the last nationally representative survey in 2010 the prevalence of cigarette smoking for adult males in China was estimated to be almost 53%1. The need to understand effective smoking cessation strategies for this population is urgent. Craving, the subjective experience of a desire or intense need for substance use2 is commonly reported by people attempting to quit smoking. Thus, cigarette craving is an important target of smoking cessation treatments3, 4.
Hypnosis can be defined as an altered state of consciousness5. It consists of two components: hypnotic induction and hypnotic suggestion6. Hypnosis can help patients to lessen pain, and anxiety, and has even been used in the invasive clinical procedures accompanying interventional radiology and oncological surgery7. For smoking cessation, the data on the efficacy of clinical hypnosis are mixed8, with some studies reporting less than 25%9 and others reporting a high success rate of more than 80% abstinence10. In their recent Cochrane database review, Barnes et al.11 concluded that most studies had methodological flaws and any treatment success may be influenced by many factors. While not specifically mentioned craving, Oakley and Halligan12 note from a cognitive neuroscience perspective that the use of hypnotic induction and suggestion is a valid way to investigate brain activity in aberrant psychological states. However, to date the neural mechanisms underlying any effect of hypnotherapy on cigarette craving remain unclear.
The functional connectivity of different brain regions can be measured via Electroencephalography (EEG) coherence, which measures the synchrony of brain activity within or across different brain areas. Coherence is the stability of the EEG phase between sensor electrode pairs. It has been used to investigate brain changes associated with substance dependence13,14,15. For these reasons, this EEG technique is useful in investigate the neural basis of the effect of hypnotherapy on cigarette craving. Measuring EEG coherence while the brain is at rest is a feasible method16. With resting state connectivity measures researchers can study the flow of mental events, which happens within the mind or mind substitute of a conscious individual, in the absence of task performance17.
EEG coherence analysis has been employed in hypnosis research since the 1990’s18. Increased theta band functional connectivity in high susceptible participants was found as a result of hypnosis19, 20. High hypnotizable individuals also showed a reduction in upper alpha band coherence21. In the high susceptibility group, beta coherence decreased from baseline to hypnosis19,20,21.
The current study investigated EEG coherence changes between the baseline state and the hypnotic state in a resting-state condition. Given that nicotine abstinence causes increases in EEG power in low-frequency bands (delta and theta) and leads to reductions in high-frequency bands (alpha and beta) during a resting state22, we expected that the delta coherence and theta coherence would increase, and alpha coherence and beta coherence would decrease in the resting state as a result of hypnosis.
There is accumulating evidence that delta rhythm is associated with the activity of the brain’s reward circuit23,24,25. Moreover, the EEG changes in the frequency domain reflect drug craving26. Specifically, previous studies have found that delta power is related to subjective craving in smokers27. Comparable results were found in cocaine users in Reid et al.’s study28, who found that self-reported cocaine craving was correlated with delta power. If delta coherence will change in the resting state, we want to know whether the change is associated with cigarette craving after hypnosis. We hypothesized that resting-state delta coherence after the hypnotic induction would predict cigarette craving.
Hypnotic induction can alter activity in the default mode network29, which itself (such as the precuneus and posterior cingulated cortex) is positively related to craving and nicotine dependence and smoking cues30,31,32,33. However, the effects of hypnotic suggestions activate brain regions is associated with suggested events, e.g., visual hallucinations activate visual cortex34. Therefore, in this study we measured resting-state delta coherence after the hypnotic induction, but not after hypnotic suggestion. Though the brain activation we wanted to measure was not caused by smoking–related hypnotic suggestion, we could still make an assumption that the brain activation during resting state after hypnotic induction may predict the change of cigarette craving.
Results
Difference in EEG power between baseline and hypnotic states
EEG power increased significantly at bilateral frontal regions in delta band and at the right frontal area in theta band. In alpha, beta and gamma bands, EEG power decreased at both bilateral frontal and posterior areas (Table 1).
Difference between states in EEG coherence and TCQ
Four regions were defined as left-frontal (LF), right-frontal (RF), left-posterior (LP) and right-posterior (RP). There were significant increases in EEG coherence in delta (RF-LP, LP-RP) and theta (RF-LP, LP-RP) bands and significant decreases in alpha (LF-RF, LF-RP, RF-RP) and beta (LF-RF) frequency bands between the baseline and the hypnotic state (Table 2 and Fig. 1A–D).
The ANOVA analysis of the scores of Tobacco Craving Questionnaire-Short Form (TCQ35) revealed a significant main effect of states (F = 10.595, p = 0.002) while the main effect of testing time didn’t reach significance (F = 3.013, p = 0.090). Post-hoc comparison showed that TCQ scores before and after the EEG scan did not differ in the baseline (t = 0.417, p = 0.679). In contrast, the difference between TCQ scores in the hypnotic state reached statistical significance (t = 2.728, p = 0.010) (Fig. 1E). The interaction between states and testing time was significant (F = 4.486, p = 0.041) (Fig. 1F).
Correlation results
After control for the scores of Stanford hypnotic susceptibility scale (SHSS)36 and Fagerström Test for Nicotine Dependence (FTND)37, EEG coherence changes between states in delta band in RF-LP and LP-RP correlated with TCQ change between states (ΔTCQ) (r = 0.333, p = 0.041; r = 0.342, p = 0.036, respectively, see Fig. 2), while EEG coherence changes in other frequency bands and EEG power in all frequency bands were not significantly correlated with ΔTCQ (all ps > 0.05).
A stepwise linear regression analysis was performed with the delta coherence in RF-LP and LP-RP as independent variables, and ΔTCQ as dependent variable. ΔTCQ was independently predicted by the delta coherence in RF-LP only (R 2 = 0.104, p = 0.043).
Discussion
The present study investigated EEG coherence changes between the baseline and the hypnotic state during a resting condition. In line with our hypotheses, a significant increase in EEG coherence in delta and theta frequency bands and significant decrease in alpha and beta frequency bands between the baseline and the hypnotic state. Previous studies found that nicotine abstinence causes increases in delta and theta power and leads to reductions in alpha and beta power during a resting state22. Further, we also found the same pattern in EEG power in the hypnotic state for smokers. That is to say, not only EEG power but also EEG coherence increased in delta and theta bands and decreased in alpha and beta bands.
Increases in theta power are correlated with drowsiness38, 39 and the transition from wakefulness to sleep40. Moreover, high delta and theta coherence is usually associated with lower levels of consciousness41, 42. Decreases in alpha frequency have been associated with slow reaction time43, diminished arousal and decreased vigilance39, 44. And the reduction in beta frequency may reflect the reduction of awareness45. Therefore, the increase in delta and theta coherence and decrease in alpha and beta coherence found in the present study may reflect alterations in consciousness after hypnotic induction. Several studies of EEG coherence during a resting hypnotized condition have been published recently46,47,48. They reported similar findings. For example, Fingelkurts et al.47 found an increase in the number of functional connections for theta frequency band and decrease of functional connectivity for beta frequency band during hypnosis. Therefore, we could speculate that increased low frequency and decreased high frequency may reflect consciousness/vigilance status. The higher the hypnotic depth of the smokers is, the more likely they are affected by the hypnotic aversion suggestions, and the more the level of cigarette cravings declines.
We found the TCQ scores decreased significantly following hypnosis, which demonstrates once again the effect of hypnotic aversion suggestions on reducing cigarette cravings. More importantly, the increase of delta coherence in RF-LP between the baseline and the hypnotic states during a resting condition can predicted the change in scores of cigarette cravings after hypnotic aversion suggestions. Previous studies demonstrate the link between delta power and cravings23,24,25, 27, 28. The delta power decrease may reflect increased activity of the dopaminergic brain reward system25, while increases in delta power reflect withdrawa23, 24. Our results further suggest that the delta coherence may also be associated with cigarette cravings. Specially, the delta coherence in RF-LP can predict the scores of cigarette cravings change between states, which suggests that the functional connectivity between the right frontal region and the left posterior region plays an important role in reducing cigarette cravings via hypnotic aversion suggestions. Frontal delta activity may reflect the state of craving. Littel et al.27 found that increases in craving were associated with left and right frontal increases in delta activity. Cocaine also produced a similar increase in delta coherence over the prefrontal cortex which was positively correlated with cue-induced cocaine craving28, 49. The left-posterior (CP5, CP1, P3, PO3, O1) may play a role in the development of cravings. Kim et al.50 found that alcohol craving results in the more complex EEG behavior in the left parietal (P3), and occipital regions (O1, O2). Although the EEG recording has a low spatial resolution, these findings in the present study support that the right frontal region and the left posterior region are activated during smoking-specific cue presentations. McClernon et al.51, using functional magnetic resonance imaging, found that cigarette craving is associated with the activation of the parietal, frontal, occipital, which provides further support for our point of view.
The present study has several clinical implications. First, while the results of the efficacy of clinical hypnosis for smoking cessation are mixed8,9,10, as pointed out by Barnes et al.11 there are many uncontrolled factors which influence the outcomes. So, it is difficult to predict the result of hypnotherapy for smoking cessation. The present study demonstrates that a measure of connectivity acquired from 8 min of resting-state EEG predicts subsequent cigarette craving. These data can be acquired rapidly, inexpensively, easily, and safely, therefore, the present EEG method has high potential clinical utility. Second, stimulating these brain regions via non-invasive brain stimulation, such as transcranial direct current stimulation or repetitive transcranial magnetic stimulation, may improve treatment efficacy52. Specially, by combining noninvasive treatments with hypnotherapy, it is possible to have an additive effect on treating the syndrome of addiction.
The present study has several limitations that should be considered. Firstly, regarding localization of coherence effects, the spatial resolution is limited because of low spatial resolution of EEG and the spatial averaging applied. Secondly, a self-reported tool to measure cigarette cravings change rather than an objective one was used in the current study, which can be biased by the influence of social desirability. Thirdly, in China, one distinctive smoking pattern in China is the disparity between the low prevalence among females and the high prevalence among males53. For this reason, only male smokers were recruited in the present study, which might limit the application of the current conclusions in clinic. Fourthly, although oscillation power and coherence are often adopted as two parallel measurement of brain activity, they may not be independent.
Conclusion
The present study demonstrates that hypnosis causes increases in delta and theta coherence, and leads to reductions in both alpha and beta coherence, indicating alterations in consciousness after hypnotic induction. Moreover, the cigarette cravings after hynoptic suggestion were predicted by the functional connectivity between the right frontal region and the left posterior region during a resting condition. These areas can be target brain regions for future studies on cigarette craving and addiction.
Materials and Methods
Participants
A total of 44 male smokers took part in the study. Data from two participants were excluded because too much artifact. The final sample consisted of 42 smokers aged 20–48 (M = 26.0, SD = 5.9) with different hypnotic susceptibility measured by SHSS36 (M = 7.5, SD = 2.8). All of the participants smoked 8 or more cigarettes per day (M = 15.0, SD = 4.7) for a minimum of 2 years (M = 7.2, SD = 4.8). Their nicotine dependence was measured by FTND37 before experiment (M = 4.6, SD = 2.2). The participants provided written informed consent and the protocol was approved by the Human Ethics Committee of University of Science and Technology of China. The experiments were performed in accordance with the approved protocol.
Experimental Design
After the preparation of EEG recording, 8-minute resting state EEG was recorded in baseline and just after hypnotic induction in hypnotic state with participants comfortably seated and eyes closed. After that, a smoking disgust suggestion was performed. For example, smokers were told that cigarettes would smell and taste like excrement (according to Spiegel et al.54). We measured resting EEG before smoking disgust suggestion because we wanted to find an EEG measurement to predict the effect of hypnosis rather than directly show the effect of smoking disgust suggestion.
The experiment in the baseline was always implemented before the experiment in the hypnotic state, to provide a baseline measure of brain activity before assessment of any effect of the hypnotic disgust suggestion. Cigarette craving was assessed before and after the EEG recording in each state by TCQ35. The procedure is shown in Fig. 3.
EEG recording
A SynAmps 2 amplifier (NeuroScan, Charlotte, NC, U.S.) was used for EEG recording. A 64-channel electrode cap with Ag/AgCl electrodes placed according to the extended international 10–20 system was laid on the scalp. The reference electrode was located on the tip of participant’s nose while the ground electrode was AFz. Electrical activities at both left and right mastoids were recorded. Vertical electrooculogram (EOG) was recorded with a bipolar-channel located above and below the left eye, and horizontal EOG was recorded with a bipolar-channel placed by the side of the outer canthus of each eye. Impedance between the reference electrode and each recording electrode was kept under 5 kΩ. 0.05–100 Hz filtered alternating current signals were continually recorded and digitized by 24 bit resolution with a sampling rate of 500 Hz.
EEG data processing
EEG data processing was performed using MatLab (MathWorks Inc., Natick, MA, USA), EEGLab55 (http://sccn.ucsd.edu/eeglab/) and customized MatLab Code. Four electrodes (M1, M2, CB1, CB2) were excluded from analysis. EOG, EMG and other artifact was rejected manually and using ICA methods. We removed 1.77 ± 2.00 components from total 62 ICA components in this study. Correcting artifacts using ICA method is widely used in EEG studies, some of which calculated coherence or other measurement relevant with phase56,57,58,59,60. We compared coherence after visual artifact rejection only and after additional ICA component rejection to investigate whether there was significant differences between the two approaches. We performed a 2 (approaches) × 2 (states) × 5 (frequency bands) × 6 (coherence in region pairs) repeated measure ANOVA and found that there was no significant difference between the two approaches (F = 0.036, p = 0.851).
The EEG of first second and data beyond 5 minutes was excluded from analysis. EEG data was segmented into epochs with 512 points (1024 ms) and detrended. Epoches contained values exceeding ±100 μV were rejected. Remain epoches were re-referenced to average reference.
Four regions were defined as left-frontal (LF: FP1, AF3, F7, F3, FC5), right-frontal (RF: FP2, AF4, F8, F4, FC6), left-posterior (LP: CP5, CP1, P3, PO3, O1) and right-posterior (RP: CP6, CP2, P4, PO4, O2). EEG power spectrum was calculated using FFT with a Hamming window (512 points) without overlap and averaged in each region in delta (0.1–3.9 Hz), theta (4–7.9 Hz), alpha (8–12.9 Hz), beta (13–29.9 Hz) and gamma (30–49.9 Hz) frequency band61.
The average cross spectrum of two electrodes, calculated from the complex conjugate of Fourier coefficients, was squared and normalized by the average residual power spectrum of each region to calculate the coherence between two electrodes across epochs at each frequency62, 63. All distances between two electrodes used in our study were larger than 5 cm, which is the estimated spatial resolution of EEG64,65,66, artifacts from volume conduction should not be an issue. And because Laplacian derivation might diminish discrimination at lower frequences and make coherence erroneous67, 68, we didn’t adopt surface Laplacian method in this study. Coherence in delta, theta, alpha, beta and gamma frequency band was calculated by averaging coherence values in each frequency interval. Frequency band coherence across multiple electrode combinations was averaged to calculate connectivity between regions.
Statistic analysis
Statistic analysis was performed using IBM SPSS Statistics 20.0 (IBM Corp, Armonk, NY, USA) and JMP 10.0.0 (SAS Institute Inc, Cary, North Carolina, USA). A 2 (states) × 2 (testing time: before/after EEG scan) repeated measure ANOVA was performed to TCQ scores and post-hoc comparisons was implemented. TCQ change between states was calculated according to the following equation: ΔTCQ = (TCQ3 − TCQ4) − (TCQ1 − TCQ2). The difference of EEG power and EEG coherence between the baseline and the hypnotic state was tested by two-tailed paired t-test. Multiple comparisons were corrected by false discovery rate (FDR) method. The correlation between ΔTCQ and difference of power and coherence between states (hypnotic state > baseline) that reached significance level was tested by two-tailed partial correlation, with the SHSS scores and the FTND scores controlled. Data controlled the SHSS and the FTND scores were calculated using the least square method. Stepwise linear regression analysis was performed to detect whether the EEG coherence change predicted the ΔTCQ.
References
Li, Q., Hsia, J. & Yang, G. Prevalence of smoking in China. N Engl J Med. 364, 2469–2470, doi:10.1056/NEJMc1102459 (2011).
American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th Edition: DSM-5. Washington D. C.: Author (2013).
Farris, S. G., Zvolenskya, M. J. & Schmidt, N. B. Smoking-specific experiential avoidance cognition: Explanatory relevance to pre- and post-cessation nicotine withdrawal, craving, and negative affect. Addict Behav. 44, 58–64, doi:10.1016/j.addbeh.2014.07.026 (2015).
Piasecki, T. M. Relapse to smoking. Clin. Psychol. Rev. 26, 196–215, doi:10.1016/j.cpr.2005.11.007 (2006).
Mendelsohn, A., Chalamish, Y., Solomonovich, A. & Dudail, Y. Mesmerizing Memories: Brain Substrates of Episodic Memory Suppression in Posthypnotic Amnesia. Neuron 57, 159–170, doi:10.1016/j.neuron.2007.11.022 (2008).
McGeown, W. J. et al. Suggested visual hallucination without hypnosis enhances activity in visual areas of the brain. Conscious Cogn. 21, 100–116, doi:10.1016/j.concog.2011.10.015 (2012).
Raz, A. Hypnosis: a twilight zone of the top-down variety Few have never heard of hypnosis but most know little about the potential of this mind-body regulation technique for advancing science. Trends Cogn Sci. 15, 555–557, doi:10.1016/j.tics.2011.10.002 (2011).
Elkins, G. R. & Rajab, M. H. Clinical hypnosis for smoking cessation: preliminary results of a three-session intervention. Int J Clin Exp Hypn. 52, 73–81, doi:10.1076/iceh.52.1.73.23921 (2004).
Ahijevych, K., Yerardi, R. & Nedilsky, N. Descriptive outcomes of the American Lung Association of Ohio hypnotherapy smoking cessation program. Int J Clin Exp Hypn. 48, 374–387, doi:10.1080/00207140008410367 (2000).
Crasilneck, H. B. Hypnotic techniques for smoking control and psychogenic impotence. Am J Clin Hypn. 32, 147–153, doi:10.1080/00029157.1990.10402818 (1990).
Barnes, J. et al. Hypnotherapy for smoking cessation. Cochrane Database Syst Rev. 6(10), CD001008, doi:10.1002/14651858.CD001008.pub2 (2010).
Oakley, D. A. & Halligan, P. W. Hypnotic suggestion and cognitive neuroscience. Trend Cog Neurosci. 13, 264–270, doi:10.1016/j.tics.2009.03.004 (2009).
Franken, I. H., Stam, C. J., Hendriks, V. M. & van den Brink, W. Electroencephalographic power and coherence analyses suggest altered brain function in abstinent male heroin-dependent patients. Neuropsychobiology 49, 105–110, doi:10.1159/000076419 (2004).
Motlagh, F. et al. Neuroelectrophysiological approaches in heroin addiction research: A review of literatures. J Neurosci Res. 94, 297–309, doi:10.1002/jnr.23703 (2016).
Michael, A., Mirza, K. A., Mukundan, C. R. & Channabasavanna, S. M. Interhemispheric electroencephalographic coherence as a biological marker in alcoholism. Acta Psychiatr Scand. 87, 213–217, doi:10.1111/j.1600-0447.1993.tb03358.x (1993).
Saunders, A., Kirk, I. J & Waldie, K. E. Hemispheric Coherence in ASD with and without Comorbid ADHD and Anxiety. Biomed Res Int. 2016, 4267842, 1–12, doi:10.1155/2016/4267842 (2016).
Friston, K. J. Functional and effective connectivity: a review. Brain Connect. 1, 13–36, doi:10.1089/brain.2011.0008 (2011).
Kaiser, J., Barker, R., Haenschel, C., Baldewag, T. & Gruzelier, J. H. Effects of hypnosis on performance and error-related EEG negativity during a modified stroop task. Int J Psychophysiol. 25, 80–80, doi:10.1016/S0167-8760(97)85571-7 (1997).
Sabourin, M. E., Cutcomb, S. D., Crawford, H. J. & Pribram, K. EEG correlates of hypnotic susceptibility and hypnotic trance: spectral analysis and coherence. Int J Psychophysiol. 10, 125–142, doi:10.1016/0167-8760(90)90027-B (1990).
Jamieson, G. A. & Burgess, A. P. Hypnotic induction is followed by state-like changes in the organization of EEG functional connectivity in the theta and beta frequency bands in high-hypnotically susceptible individuals. Front Hum Neurosci. 8, 1–11, doi:10.3389/fnhum.2014.00528 (2014).
White, D., Ciorciari, J., Carbis, C. & Liley, D. EEG correlates of virtual reality hypnosis. Int J Clin Exp Hypn 57, 94–116, doi:10.1080/00207140802463690 (2009).
Teneggi, V. et al. EEG power spectra and auditory P300 during free smoking and enforced smoking abstinence. Pharmacol Biochem Behav. 77, 103–109, doi:10.1016/j.pbb.2003.10.002 (2004).
Knyazev, G. G. Motivation, emotion, and their inhibitory control mirrored in brain oscillations. Neurosci Biobehav Rev. 31, 377–395, doi:10.1016/j.neubiorev.2006.10.004 (2007).
Knyazev, G. G. EEG delta oscillations as a correlate of basic homeostatic and motivational processes. Neurosci Biobehav Rev. 36, 677–695, doi:10.1016/j.neubiorev.2011.10.002 (2012).
Wacker, J., Dillon, D. G. & Pizzagalli, D. A. The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques. NeuroImage 46, 327–337, doi:10.1016/j.neuroimage.2009.01.058 (2009).
Knott, V. et al. EEG correlates of imagery-induced cigarette craving in male and female smokers. Addict Behav. 33, 616–621, doi:10.1016/j.addbeh.2007.11.006 (2008).
Littel, M., Franken, I. H. & Van Strien, J. W. Changes in the electroencephalographic spectrum in response to smoking cues in smokersand ex-smokers. Neuropsychobiology 59, 43–50, doi:10.1159/000205517 (2009).
Reid, M. S. et al. Quantitative electroencephalographic studies of cue-induced cocaine craving. Clin Electroencephalogr. 34, 110–123, doi:10.1177/155005940303400305 (2003).
Deeley, Q. et al. Modulating the default mode network using hypnosis. Int J Clin Exp Hypn. 60, 206–228, doi:10.1080/00207144.2012.648070 (2012).
Brewer, J. A., Garrison, K. A. & Whitfield-Gabrieli, S. What about the self isprocessed in the posterior cingulate cortex? Front Hum Neurosci. 7, 647, doi:10.3389/fnhum.2013.00647 (2013).
Claus, E. D., Blaine, S. K., Filbey, F. M., Mayer, A. R. & Hutchison, K. E. Association between nicotine dependence severity, BOLD response to smoking cues, and functional connectivity. Neuropsychopharmacology 38, 2363–2372, doi:10.1038/npp.2013.134 (2013).
Courtney, K. E., Ghahremani, D. G., London, E. D. & Ray, L. A. The association between cue-reactivity in the precuneus and level of dependence on nicotine and alcohol. Drug Alcohol Depend. 141, 21–26, doi:10.1016/j.drugalcdep.2014.04.026 (2014).
Janes, A. C., Betts, J., Jensenm, J. E. & Lukas, S. E. Dorsal anterior cingulated glutamate is associated with engagement of the default mode network during exposure to smoking cues. Drug Alcohol Depend. 167, 75–81, doi:10.1016/j.drugalcdep.2016.07.021 (2016).
Lynn, S. J., Surya Das, L., Hallquist, M. N. & Williams, J. C. Mindfulness, acceptance, and hypnosis: Cognitive and clinical perspectives. Int J Clin Exp Hypn. 54, 143–166, doi:10.1080/00207140500528240 (2006).
Heishman, S. J., Singleton, E. G. & Pickworth, W. B. Reliability and validity of a short version of the Tobacco Craving Questionnaire. Nicotine. Tob. Res. 10, 643–651, doi:10.1080/14622200801908174 (2008).
Weitzenhoffer, A. M. & Hilgard, E. R. Stanford hypnotic susceptibility scale, form C. Palo Alto, CA: Consulting Psychologists Press (1962).
Heatherton, T. F., Kozlowski, L. T., Frecker, R. C. & Fagerström, K. O. The Fagerström test for nicotine dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br. J. Addict. 86, 1119–1127, doi:10.1111/add.1991.86.issue-9 (1991). doi:0.1111/j.1360-0443.1991.tb01879.x.
Matousek, M. & Petersen, I. A method for assessing alertness fluctuations from EEG spectra. Electroencephalogr Clin Neurophysiol. 55, 108–113, doi:10.1016/0013-4694(83)90154-2 (1983).
Ulett, J. A. & Itil, T. M. Quantitative electroencephalogram in smoking and smoking deprivation. Science 164, 969–970, doi:10.1126/science.164.3882.969 (1969).
Kooi, K., Tucker, R. P. & Marshall, R. E. Fundamentals of Electroencephalography. ed 2, (Harper & Row: New York, 1978).
Fingelkurts, A. A., Fingelkurts, A. A., Bagnato, S., Boccagni, C. & Galardi, G. DMN operational synchrony relates to self-consciousness: evidence from patients in vegetative and minimally conscious states. Open Neuroimag J 6, 55–68, doi:10.2174/1874440001206010055 (2012).
Leon-Carrion, J., Martin-Rodriguez, J. F., Damas-Lopez, J., Martin, J. M. & Dominguez-Morales, M. R. Brain function in the minimally conscious state: a quantitative neurophysiological study. Clin Neurophysiol. 119, 1506–1514, doi:10.1016/j.clinph.2008.03.030 (2008).
Surwillo, W. W. The relation of simple response time to brain-wave frequency and the effects of age. Electroencephalogr Clin Neurophysiol. 15, 105–114, doi:10.1016/0013-4694(63)90043-9 (1963).
Knott, V. J. & Venables, P. H. EEG alpha correlates of non-smokers, smokers, smoking, and smoking deprivation. Psychophysiology 14, 150–156, doi:10.1111/j.1469-8986.1977.tb03367.x (1977).
Schorr, B., Schlee, W., Arndt, M. & Bender, A. Coherence in resting-state EEG as a predictor for the recovery from unresponsive wakefulness syndrome. J Neurol. 263, 937–953, doi:10.1007/s00415-016-8084-5 (2016).
Cardeña, E., Jonsson, P., Terhune, D. B. & Marcusson-Clavertz, D. The neurophenomenology of neutral hypnosis. Cortex 49, 375–385, doi:10.1016/j.cortex.2012.04.001 (2013).
Fingelkurts, A. A., Fingelkurts, A. A., Kallio, S. & Revonsuo, A. Cortex functional connectivity as a neurophysiological correlate of hypnosis: an EEG case study. Neuropsychologia 45, 1452–1462, doi:10.1016/j.neuropsychologia.2006.11.018 (2007).
Terhune, D. B., Cardeña, E. & Lindgren, M. Differential frontal-parietal phase synchrony during hypnosis as a function of hypnotic suggestibility. Psychophysiology 48, 1444–1447, doi:10.1111/j.1469-8986.2011.01211.x (2011).
Reid, M. S., Flammino, F., Howard, B., Nilsen, D. & Prichep, L. S. Topographic imaging of quantitative EEG in response to smoked cocaine self-administration in humans. Neuropsychopharmacology 31, 872–884, doi:10.1038/sj.npp.1300888 (2006).
Kim, D. J. et al. Complexity changes of the EEG induced by alcohol cue exposure in alcoholics and socialdrinkers. Alcohol Clin Exp Res. 27, 1955–1961, doi:10.1097/01.ALC.0000100943.83959.1F (2003).
McClernon, F. J., Kozink, R. V., Lutz, A. M. & Rose, J. E. 24-h smoking abstinence potentiates fMRI-BOLD activation to smoking cues in cerebral cortex and dorsal striatum. Psychopharmacology (Berl). 204, 25–35, doi:10.1007/s00213-008-1436-9 (2009).
Keeser, D. et al. Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) study. Neuroimage 55, 644–657, doi:10.1016/j.neuroimage.2010.12.004 (2011).
Su, X. et al. Smoking behaviors and intentions among adolescents in rural China: The application of the Theory of Planned Behavior and the role of social influence. Addict. Behav. 48, 44–51, doi:10.1016/j.addbeh.2015.04.005 (2015).
Spiegel, H. M. D. & Spiegel, D. M. D. Trance and Treatment: Clinical Uses of Hypnosis Second Edition Arlington, Va: American Psychiatric Publishing, Inc. (2004).
Delorme, A. & Makeig, S. EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J. Neurosci. Methods. 134, 9–21, doi:10.1016/j.jneumeth.2003.10.009 (2004).
Moazami-Goudarzi, M., Sarnthein, J., Michels, L., Moukhtieva, R. & Jeanmonod, D. Enhanced frontal low and high frequency power and synchronization in the resting EEG of parkinsonian patients. Neuroimage 41, 985–997, doi:10.1016/j.neuroimage.2008.03.032 (2008).
Cohen, M. X., Van Gaal, S., Ridderinkhof, K. R. & Lamme, V. A. Unconscious errors enhance prefrontal-occipital oscillatory synchrony. Front Hum Neurosci. 3, 54, doi:10.3389/neuro.09.054.2009 (2009).
Kam, J. W. Y., Bolbecker, A. R., O’Donnell, B. F., Hetrick, W. P. & Brenner, C. A. Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia. J Psychiatr Res. 47, 1893–1901, doi:10.1016/j.jpsychires.2013.09.009 (2013).
Wu, J., Srinivasan, R., Kaur, A. & Cramer, S. C. Resting-state cortical connectivity predicts motor skill acquisition. NeuroImage 91, 84–90, doi:10.1016/j.neuroimage.2014.01.026 (2014).
Formaggio, E. et al. Time–Frequency Modulation of ERD and EEG Coherence in Robot-Assisted Hand Performance. Brain Topogr. 28, 352–363, doi:10.1007/s10548-014-0372-8 (2015).
Egner, T., Jamieson, G. & Gruzelier, J. Hypnosis decouples cognitive control from conflict monitoring processes of the frontal lobe. Neuroimage 27, 969–978, doi:10.1016/j.neuroimage.2005.05.002 (2005).
Murias, M., Swanson, J. M. & Srinivasan, R. Functional connectivity of frontal cortex in healthy and ADHD children reflected in EEG coherence. Cereb Cortex. 17, 1788–1799, doi:10.1093/cercor/bhl089 (2007).
Murias, M., Webb, S. J., Greenson, J. & Dawson, G. Resting state cortical connectivity reflected in EEG coherence in individuals with autism. Biol Psychiatry. 62, 270–273, doi:10.1016/j.biopsych.2006.11.012 (2007).
Nunez, P. Neocortical dynamics and human EEG rhythms. Oxford University Press, New York (1995).
Lachaux, J. P., Rodriguez, E., Martinerie, J. & Varela, F. J. Measuring phase synchrony in brain signals. Hum Brain Mapp. 8, 194–208, doi:10.1002/(SICI)1097-0193 (1999).
Srinivasan, R., Winter, W. R., Ding, J. & Nunez, P. L. EEG and MEG coherence: measures of functional connectivity at distinct spatial scales of neocortical dynamics. J Neurosci Methods. 166, 41–52, doi:10.1016/j.jneumeth.2007.06.026 (2007).
Nunez, P. L. et al. EEG coherency: I: statistics, reference electrode, volume conduction, Laplacians, cortical imaging, and interpretation at multiple scales. Electroencephalogr. Clin Neurophysiol. 103, 499–515, doi:10.1016/S0013-4694(97)00066-7 (1997).
Nunez, P. L. Toward a quantitative description of large-scale neocortical dynamic function and EEG. Behav Brain Sci. 23, 371–398, doi:10.1017/S0140525X00003253 (2000).
Acknowledgements
This work was supported by the National Natural Science Foundation of China (31171083, 31230032, 31471071), the National Key Basic Research Program (2016YFA0400900), the Fundamental Research Funds for the Central Universities of China, MOE-Mircrosoft Key Laboratory of USTC, the project of human social science of Anhui province (SK2016A047), and Open Foundation of CAS Key Laboratory of Brain Function and Disease of University of Science and Technology of China (2013-3). The authors acknowledge support of the Human Ethics Committee of University of Science and Technology of China.
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X.L., L.P. and X.Z. designed research; X.L., R.M. performed research; X.L., R.M., W.L., Y.X., Y.C., P.Z., J.C., G.C. and Q.W. analyzed data; X.L., R.M., Y.Z. and X.Z. wrote the paper. All authors reviewed the manuscript and approved the final version of the manuscript for submission.
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Li, X., Ma, R., Pang, L. et al. Delta coherence in resting-state EEG predicts the reduction in cigarette craving after hypnotic aversion suggestions. Sci Rep 7, 2430 (2017). https://doi.org/10.1038/s41598-017-01373-4
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DOI: https://doi.org/10.1038/s41598-017-01373-4
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