Extended Data Fig. 8: Inhibition of PAC1R^DR neurons blocks panic-like symptoms.

a, Heat map of mouse activity before (air) and after CO₂ exposure during chemogenetic inhibition of PAC1R^DR neurons. n = 7 mice per group. b,c, Heat map of mouse activity (b) and velocity (c, mixed-effects analysis with Sidak’s multiple comparisons test and adjusted P values) after FG-7142 injection during chemogenetic inhibition of PAC1R^DR neurons. n = 7 mice per group. Data are presented as the mean ± SEM; see also Supplementary Table 3 for statistical details. **P < 0.01, ***P < 0.001.

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