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Bocaparvovirus in infants hospitalized in a neonatal intensive care unit in Midwest Brazil during the COVID-19 pandemic (2021–2022)

  • Clinical Microbiology - Research Paper
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Abstract

Human bocaparvoviruses (HBoVs) belong to the Parvoviridae family, being currently classified into four species (HBoV1–4). These viruses have been found in association with respiratory and gastroenteric symptoms, as well as in asymptomatic individuals. This study aimed to investigate the occurrence of HBoVs in infants under 5 months old admitted to a Neonatal Intensive Care Unit (NICU) during the COVID-19 pandemic (between March 2021 and March 2022). Clinical samples (nasopharyngeal swab, serum, stool, and urine) were screened by qPCR TaqMan. The HBoV was detected in samples of 31.6% (12/38) of participants. The most frequent alteration among the HBoV-positive neonates was the chest X-ray with interstitial infiltrate, followed by tachycardia and vomiting. Viral DNA was detected in more than one type of clinical sample in three of the participants in association with respiratory symptoms. Two participants had positive stool samples with or without enteric symptoms. HBoV intermittent and continuous positivity patterns were observed. The present study stands out for the prospective evaluation of positivity for HBoV in different types of clinical samples from a population of hospitalized infants. Our data supports circulation of HBoV in nosocomial environment during the COVID-19 pandemic.

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All data supporting the findings of this study are available within the manuscript and its Supplementary Information.

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Funding

This study is part of a larger Project, funded by FAPEG (202010267000279) and approved by the Research Ethics Committee of the Hospital das Clinicas/EBSERH/UFG (CAE: 30804220.2.0000.5078).

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Authors and Affiliations

  1. Laboratório de Virologia e Cultivo Celular, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Rua 235, s/n, Sala 420, Setor Leste Universitário, Goiânia, Goiás, 74605050, Brazil

    Aline de Faria Gonçalves, Déborah Anjos, Fernanda Craveiro Franco, Marcelle Silva-Sales, Fabíola Souza Fiaccadori, Pedro Soares Porto & Menira Souza

  2. Hospital das Clínicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil

    Fernanda Aparecida de Oliveira Peixoto

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  1. Aline de Faria Gonçalves
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  2. Déborah Anjos
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  3. Fernanda Aparecida de Oliveira Peixoto
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Correspondence to Menira Souza.

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de Faria Gonçalves, A., Anjos, D., de Oliveira Peixoto, F.A. et al. Bocaparvovirus in infants hospitalized in a neonatal intensive care unit in Midwest Brazil during the COVID-19 pandemic (2021–2022). Braz J Microbiol 55, 315–322 (2024). https://doi.org/10.1007/s42770-023-01184-y

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