During the summer 2020, four trees of Schinus molle grown in a tree-lined avenue located in La Crau, (Southeastern France; 43°09’31’’N 6°04’31’’E) showed leaf drying and stem cankers with reddish-brown exudates. Woody tissues were rotted and showed internal brown discoloration. The disease incidence was about 2%. Decayed woody samples were surface sterilized in 1% NaClO, then washed in sterile water. Little portions of decayed tissues were plated onto potato dextrose agar (PDA) amended with streptomycin sulfate (25 mg/L). Fungal colonies developed, initially producing a whitish fluffy aerial mycelium that became dark grayish after 4–5 days. On pine needle agar (PNA), mature pycnidia produced only unicellular conidia, ellipsoidal in shape with tapered ends, measuring 16.1–22.4 × 5.1–6.8 μm. The DNA of the isolate 22-20-O was extracted and a PCR was performed to amplify the translation elongation factor 1-alpha (tef-1α) with the primers EF1-728 F/EF1-986R (Carbone and Kohn, 1999) and the β-tubulin (tub) with the primers BT2a and BT2b (Glass and Donaldson, 1995). Two sequences were obtained (GenBank accession numbers ON568671; ON568670), whose BLAST analysis showed 100% and 99.3% identity with tef-1α and tub sequences of Neofusicoccum parvum strain CMW9081 (AY236888 and AY236917). The phylogenetic tree generated confirmed the isolate 22-20-O clustering with N. parvum. Mycelium disks of the isolate 22-20-O were inoculated by wounds through the base of the branch tissues of three 8-year-old plants of S. molle (three branches for plant). The wounds were covered with gauze wetted with sterile water and protected with parafilm. Three control plants were treated with sterile PDA disks. Plants were maintained at temperatures ranging from 18 to 34 °C. One month after the inoculation, internal tissues of inoculated branches showed brown discoloration, and N. parvum was reisolated and identified through tef-1α sequencing. Control plants remained healthy. To our knowledge, this is the first report of N. parvum on S. molle in France (Farr and Rossman, 2022). At present, the economic importance of this disease is limited, but it may become a more significant problem due to the extent of the cultivation of S. molle in Mediterranean countries. The isolate 22-20-O has been deposited at the AGROINNOVA Collection, University of Torino, Italy.