Log in

Management of atypical cellular angiofibroma arising in the oral cavity using Er, Cr: YSGG laser: a case report

  • Case Report
  • Published:
Lasers in Dental Science Aims and scope Submit manuscript

Abstract

Purpose

Cellular angiofibroma (CAF) is a rare mesenchymal neoplasm that usually arises in the genital region. It is comprised of cellular fibrous tissue stroma with an enhanced vascular component in the form of blood vessels with varying sizes. It is commonly treated by surgical excision. We report an atypical presentation of CAF in the oral cavity and discuss aspects related to its clinicopathological characteristics. Lasers are becoming widely used in the management of oral lesions due to their beneficial effects such as: less pain, bleeding, appropriate homeostasis, shorter recovery times, fewer analgesics used. This is the first case of CAF treated with laser.

Methods

The lesion was completely excised with Er, Cr: YSGG 2780 nm laser (WaterLase iPlus®, Foothill Ranch, CA, USA) with parameters (2.5 W, 40 Hz, air 20, water 40, H mode, tip MZ6). Histological examination and immunohistochemical interpretation were done revealing the diagnosis of CAF.

Results

There was less post operative pain and minimal bleeding to the patient with antibacterial effect. Also, there were no complications nor recurrence after two weeks and 6 months of follow up.

Conclusion

Laser offers a new and effective treatment of CAF develo** in the oral cavity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Flucke U, van Krieken JHJM, Mentzel T (2011) Cellular Angiofibroma: analysis of 25 cases emphasizing its relationship to spindle cell lipoma and mammary-type myofibroblastoma. Mod Pathol 24:82–89

    Article  PubMed  Google Scholar 

  2. Nucci MR, Granter SR, Fletcher CD (1997) Cellular Angiofibroma: a benign neoplasm distinct from angiomyofibroblastoma and spindle cell lipoma. Am J Surg Pathol 21(6):636–644

    Article  CAS  PubMed  Google Scholar 

  3. Eleanor C, Christopher F (2010) Cellular Angiofibroma with atypia or sarcomatous transformation: clinicopathologic analysis of 13 cases. Am J Surg Pathol 34(5):707–714

    Article  Google Scholar 

  4. Iwasa Y, Fletcher CD (2004) Cellular Angiofibroma: clinicopathologic and immunohistochemical analysis of 51 cases. Am J Surg Pathol 28(11):1426–1435

    Article  PubMed  Google Scholar 

  5. Christopher DMF (2021) Tumors of soft tissue. In: Christopher DMF (ed) Diagnostic histopathology of tumors, 5th edn. Elsevier, Philadelphia, pp 1919–2001

    Google Scholar 

  6. Moshonov J, Stabholz A, Leopold Y, Rosenberg I (2001) Lasers in dentistry. Part B–Interaction with biological tissues and the effect on the soft tissues of the oral cavity, the hard tissues of the tooth and the dental pulp. Refu’at Ha-peh Veha-shinayim (1993), 18(3–4): 21–28

  7. Coluzzi DJ (2000) An overview of laser wavelengths used in dentistry. Dent Clin N Am 44(4):753–765

    Article  CAS  PubMed  Google Scholar 

  8. Coluzzi DJ (2004) Fundamentals of dental lasers: science and instruments. Dent Clin 48(4):751–770

    Google Scholar 

  9. Pié-Sánchez J, España-Tost AJ, Arnabat-Domínguez J, Gay-Escoda C (2012) Comparative study of upper lip frenectomy with the CO2 laser versus the Er, Cr: YSGG laser. Medicina oral, patologia oral y cirugia bucal 17(2), e228

  10. Christopher DMF (2021) Tumors of the upper respiratory tract. In: Christopher DMF (ed) Diagnostic histopathology of tumors, 5th edn. Elsevier, Philadelphia, pp 96–224

    Google Scholar 

  11. Martins MB, Lima FV, Mendonça CA, Jesus EP, Santos AC, Barreto VM, Santos Júnior RC (2013) Nasopharyngeal angiofibroma: our experience and literature review. Int Arch Otorhinolaryngol 17:14–19

    PubMed  PubMed Central  Google Scholar 

  12. Sánchez-Romero C, Carlos R, Díaz Molina JP, Thompson LD, de Almeida OP, Rumayor Piña A (2018) Nasopharyngeal angiofibroma: a clinical, histopathological and immunohistochemical study of 42 cases with emphasis on stromal features. Head Neck Pathol 12:52–61

    Article  PubMed  Google Scholar 

  13. Bekers EM, Groenen PJ, Verdijk MA, Raaijmakers-van Geloof WL, Roepman P, Vink R, Gilhuijs ND, van Gorp JM, Bovée JV, Creytens DH, Flanagan AM (2017) Soft tissue angiofibroma: clinicopathologic, immunohistochemical and molecular analysis of 14 cases. Genes Chromosomes Cancer 56(10):750–757

    Article  CAS  PubMed  Google Scholar 

  14. Mandato VD, Santagni S, Cavazza A, Aguzzoli L, Abrate M, La Sala GB (2015) Cellular Angiofibroma in women: a review of the literature. Diagn Pathol 10(1):1–10

    Article  Google Scholar 

  15. Eversole LR (2009) Cellular Angiofibroma of oral mucosa: report of two cases. Head Neck Pathol 3(2):136–139

    Article  PubMed  PubMed Central  Google Scholar 

  16. Strauss RA, Fallon SD (2004) Lasers in contemporary oral and maxillofacial surgery. Dent Clin 48(4):861–888

    Google Scholar 

  17. Cercadillo-Ibarguren I, España Tost AJ, Arnabat Domínguez J, Valmaseda Castellón E, Berini Aytés L, Gay Escoda C (2010) Histologic evaluation of thermal damage produced on soft tissues by CO2, er, Cr: YSGG and diode lasers. Med Oral Patol Oral Cir Bucal 15(6):912–918

    Article  Google Scholar 

  18. Verma SK, Maheshwari S, Singh RK, Chaudhari PK (2012) Laser in dentistry: an innovative tool in modern dental practice. Natl J Maxillofac Surg 3(2):124–132

    Article  PubMed  PubMed Central  Google Scholar 

  19. Vescovi P, Corcione L, Meleti M, Merigo E, Fornaini C, Manfredi M, Bonanini M, Govoni P, Rocca JP, Nammour S (2010) Nd: YAG laser versus traditional scalpel. A preliminary histological analysis of specimens from the human oral mucosa. Lasers Med Sci 25:685–691

    Article  PubMed  Google Scholar 

  20. ** JY, Lee SH, Yoon HJ (2010) A comparative study of wound healing following incision with a scalpel, diode laser or er, Cr: YSGG laser in guinea pig oral mucosa: a histological and immunohistochemical analysis. Acta Odontol Scand 68(4):232–238

    Article  CAS  PubMed  Google Scholar 

  21. Ryu SW, Lee SH, Yoon HJ (2012) A comparative histological and immunohistochemical study of wound healing following incision with a scalpel, CO2 laser or er, Cr:YSGG laser in the guinea pig oral mucosa. Acta Odontol Scand 70(6):448–454

    Article  CAS  PubMed  Google Scholar 

  22. Rizoiu IM, Eversole LR, Kimmel AI (1996) Effects of an erbium, chromium: yttrium, scandium, gallium, garnet laser on mucocutanous soft tissues. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 82(4):386–395

    Article  CAS  PubMed  Google Scholar 

  23. Eroglu CN, Tunc SK, Elasan S (2015) Removal of epulis fissuratum by Er, Cr: YSGG laser in comparison with the conventional method. Photomed Laser Surg 33(11):533–539

    Article  CAS  PubMed  Google Scholar 

  24. Monteiro L, Delgado ML, Garcês F, Machado M, Ferreira F, Martins M, Salazar F, Pacheco JJ (2019) A histological evaluation of the surgical margins from human oral fibrous-epithelial lesions excised with CO2 laser, Diode laser, Er: YAG laser, nd: YAG laser, electrosurgical scalpel and cold scalpel. Med Oral Patol Oral Cir Bucal 24(2):e271–e280

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Author information

Authors and Affiliations

Authors

Contributions

All authors contributed to the study conception and design. Sara S. Elessawey carried put the procedure under the supervision of Rania A. Fahmy. Histopathological examination and immunohistochemical interpretation were done by Nourhan A. Abou Madawi and Hagar A. El-Naggar. The first draft of the manuscript was written by Sara S. Elessawey and Nourhan A. Abou Madawi. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sara S. Elessawey.

Ethics declarations

Competing interests

The authors have no relevant financial or non-financial interests to disclose.

Ethics approval

Not applicable

Consent to participate

Informed consent was obtained from the participant.

Consent to publish

Informed consent was obtained from the participant.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Elessawey, S.S., Fahmy, R.A., El-Naggar, H.A. et al. Management of atypical cellular angiofibroma arising in the oral cavity using Er, Cr: YSGG laser: a case report. Laser Dent Sci 8, 35 (2024). https://doi.org/10.1007/s41547-024-00247-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s41547-024-00247-z

Keywords

Navigation