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Hybrid cardiac PET/MR: the value of multiparametric assessment in cardiac sarcoidosis

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Abstract

Purpose

The advent of hybrid positron emission tomography/magnetic resonance (PET/MR) systems has opened the gate to integrated multiparametric evaluation of patients with suspected cardiac sarcoidosis. The aim of the present paper is to systematically review all available literature to define the role of hybrid PET/MR in patients with confirmed or suspected cardiac sarcoidosis.

Methods

The review strategy was developed following the PRISMA 2009 statement. An electronic database (Medline, Google Scholar, Clinical Trials.gov) search was conducted to identify articles on hybrid PET/MR in cardiac sarcoidosis. Only reports on hybrid PET/MR systems were considered. All PET tracers were considered. No date limitation was applied. Following duplicate removal, abstracts or full articles in case of case reports were screened for inclusion criteria. The full text of the remaining studies was reviewed.

Results

Eleven studies were found, including seven case reports, two case series, and two diagnostic accuracy studies. All studies reported feasibility and interpretability of cardiac 18F-FDG PET/MR in cardiac sarcoidosis. The two case series demonstrated non-inferiority of PET/MR compared to PET/CT and, in fact, suggested greater sensitivity. Diagnostic accuracy studies showed satisfactory sensitivity and specificity of PET/MR to diagnose cardiac sarcoidosis. Two reports also showed the usefulness of cardiac PET/MR to assess response to treatment.

Conclusion

Hybrid cardiac PET/MR is a valuable tool for the diagnosis of cardiac sarcoidosis. Moreover, as it offers activity and tissue characterisation, it can be used to tailor and monitor treatment.

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Acknowledgement

NIH/NHLBI R01HL071021 funding.

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Authors and Affiliations

  1. IRCCS San Raffaele Scientific Institute Raffaele Hospital, Vita Salute University, Via Olgettina 58, 20132, Milan, Italy

    V. Vergani, P. Mapelli, M. Picchio & P. G. Camici

  2. Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA

    V. Vergani, M. G. Trivieri, P. M. Robson & Z. A. Fayad

  3. Nuclear Medicine Department, IRCCS San Raffaele Scientific Institute, Milan, Italy

    E. Busnardo, P. Mapelli, P. Ferro, L. Gianolli & M. Picchio

  4. Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    M. G. Trivieri

  5. Department of Nuclear Medicine, European University of Brittany, EA3878 GETBO, University Hospital of Brest, 2 Avenue Foch, 29200, Brest, France

    R. Abrgral

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  1. V. Vergani
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Contributions

VV: content planning, literature search, literature review, writing, editing. FP: content planning, literature review, editing. BE: content planning, literature review, editing. MP: content planning, literature review, editing. MGT: literature review, editing. RP: literature review, editing. AR: literature review, editing. FZA: literature review, editing. LG: content planning, editing. PM: content planning, literature review, editing. CPG: content planning, literature review, editing.

Corresponding author

Correspondence to V. Vergani.

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Conflict of interest

Vittoria Vergani, Ferro Paola, Busnardo Elena, Mapelli Paola, Trivieri Maria G, Robson Philip, Abrgral Ronan, Fayad Zahi A, Gianolli Luigi, Camici Paolo G declare that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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M Picchio received support for travel expenses for attending a meeting from GE Healthcare. GE Healthcare had no involvement in writing this manuscript.

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Vergani, V., Busnardo, E., Mapelli, P. et al. Hybrid cardiac PET/MR: the value of multiparametric assessment in cardiac sarcoidosis. Clin Transl Imaging 7, 317–326 (2019). https://doi.org/10.1007/s40336-019-00345-0

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  • DOI: https://doi.org/10.1007/s40336-019-00345-0

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