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Pulsatile Tinnitus: Differential Diagnosis and Approach to Management

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Abstract

Purpose of Review

The purpose of this review is to provide an updated approach to the evaluation and management of pulsatile tinnitus (PT), an uncommon but often treatable subtype of tinnitus.

Recent Findings

Secondary PT can be due to either vascular or non-vascular etiologies, including, but not limited to: neoplasm, arteriovenous malformation or fistula, idiopathic intracranial hypertension, dural venous sinus stenosis, otoacoustic etiologies (e.g., otosclerosis, patulous eustachian tube) and bony defects (e.g., superior semicircular canal dehiscence). Computed tomography (CT) and magnetic resonance imaging (MRI) imaging have comparable diagnostic yield, though each may be more sensitive to specific etiologies. If initial vascular imaging is negative and a vascular etiology is strongly suspected, digital subtraction angiography (DSA) may further aid in the diagnosis. Many vascular etiologies of PT can be managed endovascularly, often leading to PT improvement or resolution. Notably, venous sinus stenting is an emerging therapy for PT secondary to idiopathic intracranial hypertension with venous sinus stenosis.

Summary

Careful history and physical exam can help establish the differential diagnosis for PT and guide subsequent evaluation and management. Additional studies on the efficacy and long-term outcome of venous sinus stenting for venous stenosis are warranted.

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Data Availability

No datasets were generated or analysed during the current study.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Crummer RW, Hassan GA. Diagnostic approach to tinnitus. Am Fam Physician. 2004;69(1):120–6.

    PubMed  Google Scholar 

  2. Wenjuan L, et al. Temporal bone pneumatization and pulsatile tinnitus caused by sigmoid sinus diverticulum and/or dehiscence. Biomed Res Int. 2015;2015:970613.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Hofmann E, et al. Pulsatile tinnitus: imaging and differential diagnosis. Dtsch Arztebl Int. 2013;110(26):451–8.

    PubMed  PubMed Central  Google Scholar 

  4. Sonmez G, et al. Imaging of pulsatile tinnitus: a review of 74 patients. Clin Imaging. 2007;31(2):102–8.

    Article  PubMed  Google Scholar 

  5. Mattox DE, Hudgins P. Algorithm for evaluation of pulsatile tinnitus. Acta Otolaryngol. 2008;128(4):427–31.

    Article  PubMed  Google Scholar 

  6. •• Lynch P, et al. Diagnosing pulsatile tinnitus: a review of 251 patients. Otol Neurotol. 2022;43(1):128–36. Large cohort with detailed etiology, diagnosis and outcome analysis.

    Article  PubMed  Google Scholar 

  7. Madani G, Connor SE. Imaging in pulsatile tinnitus. Clin Radiol. 2009;64(3):319–28.

    Article  CAS  PubMed  Google Scholar 

  8. Vijayakumar KA, et al. A review on peripheral tinnitus, causes, and treatments from the perspective of autophagy. Exp Neurobiol. 2022;31(4):232–42.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Makar SK. Etiology and pathophysiology of tinnitus - a systematic review. Int Tinnitus J. 2021;25(1):76–86.

    Article  PubMed  Google Scholar 

  10. Shahsavarani S, et al. Salience, emotion, and attention: The neural networks underlying tinnitus distress revealed using music and rest. Brain Res. 2021;1755:147277.

    Article  CAS  PubMed  Google Scholar 

  11. Jimoh Z, et al. Functional brain regions linked to tinnitus pathology and compensation during task performance: a systematic review. Otolaryngol Head Neck Surg. 2023;169(6):1409–23.

    Article  PubMed  Google Scholar 

  12. • Narsinh KH, et al. Diagnostic approach to pulsatile tinnitus: a narrative review. JAMA Otolaryngol Head Neck Surg. 2022;148(5):476–83. Comprehensive review of structural, metabolic and vascular etiology of pulsatile tinnitus.

    Article  PubMed  Google Scholar 

  13. Pegge SAH, et al. Pulsatile tinnitus: Differential diagnosis and radiological work-up. Curr Radiol Rep. 2017;5(1):5.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Deuschl C, et al. Value of DSA in the diagnostic workup of pulsatile tinnitus. PLoS ONE. 2015;10(2):e0117814.

    Article  PubMed  PubMed Central  Google Scholar 

  15. • Tao AJ, Parikh NS, Patsalides A. The role of noninvasive imaging in the diagnostic workup for pulsatile tinnitus. Neuroradiol J. 2022;35(2):220–5. Utility of various diagnostic imaging modality.

    Article  PubMed  Google Scholar 

  16. • Cummins DD, et al. Cerebrovascular pulsatile tinnitus: causes, treatments, and outcomes in 164 patients with neuroangiographic correlation. J Neurointerv Surg. 2023;15(10):1014–20. Large cohort with detailed etiology and outcomeanalysis.

    Article  PubMed  Google Scholar 

  17. • Raz E. Emergence of venous stenosis as the dominant cause of pulsatile tinnitus. Stroke: Vasc Interv Neurol. 2022;2(4):e000154. Large cohort with detailed etiology and outcome analysis.

    Google Scholar 

  18. Remley KB, et al. Pulsatile tinnitus and the vascular tympanic membrane: CT, MR, and angiographic findings. Radiology. 1990;174(2):383–9.

    Article  CAS  PubMed  Google Scholar 

  19. Dietz RR, et al. MR imaging and MR angiography in the evaluation of pulsatile tinnitus. AJNR Am J Neuroradiol. 1994;15(5):879–89.

    CAS  PubMed  PubMed Central  Google Scholar 

  20. Waldvogel D, et al. Pulsatile tinnitus–a review of 84 patients. J Neurol. 1998;245(3):137–42.

    Article  CAS  PubMed  Google Scholar 

  21. Krishnan A, et al. CT arteriography and venography in pulsatile tinnitus: preliminary results. AJNR Am J Neuroradiol. 2006;27(8):1635–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Sismanis A. Pulsatile tinnitus. A 15-year experience. Am J Otol. 1998;19(4):472–7.

    CAS  PubMed  Google Scholar 

  23. Sismanis A. Pulsatile tinnitus: contemporary assessment and management. Curr Opin Otolaryngol Head Neck Surg. 2011;19(5):348–57.

    Article  PubMed  Google Scholar 

  24. Essibayi MA, et al. Venous causes of pulsatile tinnitus: clinical presentation, clinical and radiographic evaluation, pathogenesis, and endovascular treatments: a literature review. Neurosurgery. 2021;89(5):760–8.

    Article  PubMed  Google Scholar 

  25. **ree GM, et al. Neurosurgical causes of pulsatile tinnitus: contemporary update. Neurosurgery. 2022;90(2):161–9.

    Article  PubMed  Google Scholar 

  26. Suzuki H, et al. MR imaging of idiopathic intracranial hypertension. AJNR Am J Neuroradiol. 2001;22(1):196–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  27. Thurtell MJ. Idiopathic intracranial hypertension. Continuum (Minneap Minn). 2019;25(5):1289–309.

    PubMed  Google Scholar 

  28. ICHD3. Headache Classification Committee of the International Headache Society (IHS) the international classification of headache disorders, 3rd edition. Cephalalgia. 2018;38(1):1–211.

    Article  Google Scholar 

  29. Narsinh KH, et al. Management of vascular causes of pulsatile tinnitus. J Neurointerv Surg. 2022;14(11):1151–7.

    Article  PubMed  PubMed Central  Google Scholar 

  30. • Fiani B, et al. Venous sinus stenting for intractable pulsatile tinnitus: a review of indications and outcomes. Surg Neurol Int. 2021;12:81. Role of venous sinus stenting specifically in pulsatile tinnitus patients (most studies were in idiopathic intracranial hypertension patients).

    Article  PubMed  PubMed Central  Google Scholar 

  31. Garner RM, et al. Quality of life, need for retreatment, and the re-equilibration phenomenon after venous sinus stenting for idiopathic intracranial hypertension. J Neurointerv Surg. 2021;13(1):79–85.

    Article  PubMed  Google Scholar 

  32. • Zhao K, et al. Advances in the understanding of the complex role of venous sinus stenosis in idiopathic intracranial hypertension. J Magn Reson Imaging. 2022;56(3):645–54. Comprehensive review of complex pathophysiological relationship between IIH and VSS.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Levitt MR, et al. Venous sinus stenting in patients without idiopathic intracranial hypertension. J Neurointerv Surg. 2017;9(5):512–5.

    Article  PubMed  Google Scholar 

  34. Patsalides A, et al. Venous sinus stenting for the treatment of isolated pulsatile tinnitus: Results of a prospective trial. Interv Neuroradiol. 2021;27(2):266–74.

    Article  PubMed  Google Scholar 

  35. DeHart AN, Shaia WT, Coelho DH. Hydroxyapatite cement resurfacing the dehiscent jugular bulb: Novel treatment for pulsatile tinnitus. Laryngoscope. 2018;128(5):1186–90.

    Article  PubMed  Google Scholar 

  36. Lehmann MF, et al. Pulsatile tinnitus: a symptom of chronic subclavian artery occlusion. AJNR Am J Neuroradiol. 2005;26(8):1960–3.

    PubMed  PubMed Central  Google Scholar 

  37. Kim JM, Kim CD, Kim SW. A case of pulsatile tinnitus from the atherosclerosis and atheroma in superior labial artery and facial artery. Korean J Audiol. 2012;16(3):156–8.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Hakimi R, Sivakumar S. Imaging of carotid dissection. Curr Pain Headache Rep. 2019;23(1):2.

    Article  PubMed  Google Scholar 

  39. Shimizu Y, Yagi M. Pulsatile tinnitus and carotid artery dissection. Auris Nasus Larynx. 2018;45(1):175–7.

    Article  PubMed  Google Scholar 

  40. Chen L, et al. Pulsatile tinnitus was the only manifestation of internal carotid artery dissection. Neurol Sci. 2021;42(3):1221–2.

    Article  PubMed  Google Scholar 

  41. Kim SM, Kim CH, Lee CY. Petrous carotid aneurysm causing pulsatile tinnitus: Case report and review of the literature. J Cerebrovasc Endovasc Neurosurg. 2018;20(1):35–9.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Kim DK, et al. Pulsatile tinnitus as the sole manifestation of an internal carotid artery aneurysm successfully treated by coil embolization. Clin Exp Otorhinolaryngol. 2012;5(3):170–2.

    Article  PubMed  PubMed Central  Google Scholar 

  43. • Pillai A, et al. Extracranial internal carotid aneurysm manifesting with tinnitus: a rare presentation. Cureus. 2022;14(1):e21349. An interesting case of PT associated with an extracranial aneurysm.

    PubMed  PubMed Central  Google Scholar 

  44. Gupta VK, Thakker A, Gupta KK. Vestibular schwannoma: What we know and where we are heading. Head Neck Pathol. 2020;14(4):1058–66.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Carlson ML, Link MJ. Vestibular schwannomas. N Engl J Med. 2021;384(14):1335–48.

    Article  PubMed  Google Scholar 

  46. Woolen S, Gemmete JJ. Paragangliomas of the head and neck. Neuroimaging Clin N Am. 2016;26(2):259–78.

    Article  PubMed  Google Scholar 

  47. Quick ME, et al. Endoscopic management of early stage middle ear paragangliomas - an Australian case series. Otol Neurotol. 2021;42(10):e1677–82.

    Article  PubMed  Google Scholar 

  48. Killeen DE, et al. Endoscopic management of middle ear paragangliomas: a case series. Otol Neurotol. 2017;38(3):408–15.

    Article  PubMed  Google Scholar 

  49. • Paulose AA, et al. Etiopathology and prevalence of pulsatile tinnitus in a tertiary care referral hospital. Indian J Otolaryngol Head Neck Surg. 2022;74(Suppl 3):3939–46. A more recent and larger cohort of PT.

    Article  PubMed  Google Scholar 

  50. Jordan JA, et al. Stereotactic radiosurgery for glomus jugulare tumors. Laryngoscope. 2000;110(1):35–8.

    Article  CAS  PubMed  Google Scholar 

  51. Tse V, et al. Glomus tumors treated with stereotactic radiosurgery: a retrospective study. J Radiosurg SBRT. 2017;5(1):73–81.

    PubMed  PubMed Central  Google Scholar 

  52. Moore A, Cunnane M, Fleming JC. Metastatic breast carcinoma presenting as unilateral pulsatile tinnitus: a case report. Ear Nose Throat J. 2015;94(2):E6-8.

    Article  PubMed  Google Scholar 

  53. Virk JS, Randhawa PS, Saeed SR. Endolymphatic sac tumour: case report and literature review. J Laryngol Otol. 2013;127(4):408–10.

    Article  CAS  PubMed  Google Scholar 

  54. Conway RM, Tu NC, Schutt CA. Pulsatile tinnitus in a patient with a skull base lesion. JAMA Otolaryngol Head Neck Surg. 2021;147(9):822–3.

    Article  PubMed  Google Scholar 

  55. Liyanage SH, et al. Pulsatile tinnitus. J Laryngol Otol. 2006;120(2):93–7.

    Article  CAS  PubMed  Google Scholar 

  56. • Zafar N, Hohman MH, Khan MAB. Otosclerosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560671/ [Updated 2024 Mar 1]. Comprehensive review or otosclerosis.

  57. Virk JS, Singh A, Lingam RK. The role of imaging in the diagnosis and management of otosclerosis. Otol Neurotol. 2013;34(7):e55–60.

    Article  PubMed  Google Scholar 

  58. • Kennedy KL, Singh AK. Middle Ear Cholesteatoma. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. 2024. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448108/. [Updated 2023 Jul 4]. Comprehensive review of cholesteatoma.

  59. • Pachpande TG, Singh CV. Diagnosis and treatment modalities of cholesteatomas: a review. Cureus. 2022;14(11):e31153. Comprehensive review of cholesteatoma.

    PubMed  PubMed Central  Google Scholar 

  60. Fortune DS, Haynes DS, Hall JW III. Tinnitus Current evaluation and management. Med Clin North Am. 1999;83(1):153–62, x.

    Article  CAS  PubMed  Google Scholar 

  61. Ward BK, et al. Superior semicircular canal dehiscence syndrome: Diagnostic criteria consensus document of the committee for the classification of vestibular disorders of the Barany Society. J Vestib Res. 2021;31(3):131–41.

    Article  PubMed  PubMed Central  Google Scholar 

  62. Ward BK, Ashry Y, Poe DS. Patulous eustachian tube dysfunction: patient demographics and comorbidities. Otol Neurotol. 2017;38(9):1362–9.

    Article  PubMed  Google Scholar 

  63. Ellenstein A, Yusuf N, Hallett M. Middle ear myoclonus: two informative cases and a systematic discussion of myogenic tinnitus. Tremor Other Hyperkinet Mov (N Y). 2013 Apr 15;3:tre-03-103-3713-1.

  64. Bhimrao SK, Masterson L, Baguley D. Systematic review of management strategies for middle ear myoclonus. Otolaryngol Head Neck Surg. 2012;146(5):698–706.

    Article  PubMed  Google Scholar 

  65. • Kontorinis G, Lenarz T. Superior semicircular canal dehiscence: a narrative review. J Laryngol Otol. 2022;136(4):284–92. Comprehensive review of semicircular canal dehiscence with helpful images.

    Article  CAS  PubMed  Google Scholar 

  66. Nieto P, et al. Surgical treatments of superior semicircular canal dehiscence: A single-centre experience in 63 cases. Laryngoscope Investig Otolaryngol. 2021;6(6):1414–20.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Schecklmann M, et al. Psychophysiological associations between chronic tinnitus and sleep: a cross validation of tinnitus and insomnia questionnaires. Biomed Res Int. 2015;2015:461090.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Belli H, et al. Psychopathological dimensions of tinnitus and psychopharmacologic approaches in its treatment. Gen Hosp Psychiatry. 2012;34(3):282–9.

    Article  PubMed  Google Scholar 

  69. • Hackenberg B, Döge J, O’Brien K, et al. Tinnitus and its relation to depression, anxiety, and stress-a population-based cohort study. J Clin Med. 2023;12(3):1169. Good review of psychological effects of tinnitus and some comparison between PT and NPT.

  70. Joos K, Vanneste S, De Ridder D. Disentangling depression and distress networks in the tinnitus brain. PLoS ONE. 2012;7(7):e40544.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  71. Henry JA, Dennis KC, Schechter MA. General review of tinnitus: prevalence, mechanisms, effects, and management. J Speech Lang Hear Res. 2005;48(5):1204–35.

    Article  PubMed  Google Scholar 

  72. • Williams AP, et al. Anxiety, depression, and symptom severity in patients with pulsatile and non-pulsatile tinnitus. Laryngoscope. 2023;133(3):683–8. Specific comparison of psychological consequences between PT and NPT patients.

    Article  CAS  PubMed  Google Scholar 

  73. Jun HJ, Park MK. Cognitive behavioral therapy for tinnitus: evidence and efficacy. Korean J Audiol. 2013;17(3):101–4.

    Article  PubMed  PubMed Central  Google Scholar 

  74. Phillips JS, McFerran D. Tinnitus Retraining Therapy (TRT) for tinnitus. Cochrane Database Syst Rev. 2010;2010(3):CD007330.

    PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We sincerely appreciate the medical illustration team of Mayo Clinic, specifically Mr. Jim Postier, for the assistance in the illustration used in this article.

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H.W. and J.S. wrote the main manuscript. H.W. prepared Table 1. C.R. revised the manuscript critically. All authors reviewed the manuscript.

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Correspondence to Han Wang.

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Wang, H., Stern, J.I., Robertson, C.E. et al. Pulsatile Tinnitus: Differential Diagnosis and Approach to Management. Curr Pain Headache Rep (2024). https://doi.org/10.1007/s11916-024-01263-1

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