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Green and accurate analytical method for monitoring atropine in foodstuffs as a contaminant and in pharmaceutical samples

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Abstract

Nowadays, atropine has been highlighted because of its anticholinergic effect and contamination in foodstuffs, and therefore, using an accurate and sensitive method for its determination is crucial in human health and food safety. In this study, a novel spectrophotometric method was suggested for the swift quantification of atropine. The proposed method was based on the formation of red ion-pair complexes between the drugs and the cyanidin reagent extracted from red cabbage (RC). In this regard, the effect of pH, time, and temperature was explored and optimized. According to the results, atropine determining was shown the best performance in pH 2 at room temperature in 30 min. In addition, this method revealed linear responses from 10 nM to 1 µM of atropine with limit of detection (LOD) value of 0.0019 µM. Also, the selectivity value of this method was investigated in the presence of some drugs with the same structure and some common species as interferences. The results verified no interference in atropine determination, as well as, the results obtained from repeatability (RSD ⁓ 2.56) of this method were acceptable. Moreover, the applicability of this method was tested in buckwheat and atropine sulfate as food and pharmaceutical real sample, respectively. Real sample analysis was carried out with the standard addition method and the recovery percentages (96.54–104.87%) witnessed the high capability of this method in atropine determination.

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The data supporting this study’s findings are available from the corresponding author upon reasonable request.

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University, 06560, Ankara, Turkey

    Yasamin Hamidian, Reza Mostafazadeh & Nevin Erk

  2. Department of Electricity and Energy, Vocational School of Technical Sciences, Akdeniz University, 07070, Antalya, Turkey

    Ceren Karaman

  3. School of Engineering, Lebanese American University, Byblos, Lebanon

    Ceren Karaman

  4. Departamento de Química Inorgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica de Chile, 7820436, Santiago, Chile

    Maria Belen Camarada

  5. Centro Investigación en Nanotecnología y Materiales Avanzados, CIEN-UC, Pontificia Universidad Católica de Chile, Santiago, Chile

    Maria Belen Camarada

  6. “Cristofor Simionescu” Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University, Bld Mangeron No 73, 700050, Iasi, Romania

    Elena-Niculina Dragoi

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  1. Yasamin Hamidian
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Hamidian, Y., Mostafazadeh, R., Erk, N. et al. Green and accurate analytical method for monitoring atropine in foodstuffs as a contaminant and in pharmaceutical samples. Food Measure 17, 4870–4880 (2023). https://doi.org/10.1007/s11694-023-01972-y

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