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Dispersive Solid Phase Extraction/Back-Extraction Using Carbon Nanotubes as Sorbent for HPLC/UV Determination of Ibuprofen in Human Blood Serum Samples

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Pharmaceutical Chemistry Journal Aims and scope

Dispersive solid phase extraction/back–extraction of Ibuprofen using multi-walled carbon nanotubes as sorbent was studied. The effects of some factors on Ibuprofen extraction were investigated. pH of IP solution and temperature were more effective on IP adsorption than other investigated parameters. The obtained preconcentration factor was 11.43. A linear range of 10.31 – 206.28 mg/L (R2 = 0.997) was obtained for the HPLC method. The detection limit and relative standard deviation were 4.93 mg/l and 2.27%, respectively. Extraction and HPLC/UV determination of Ibuprofen in the human blood serum samples was carried out efficiently using the suggested procedure. The obtained results showed satisfactory selectivity and efficiency for the extraction of Ibuprofen molecules from the matrix of the Human blood serum samples. The suggested method is simple, efficient, fast, without usage of organic solvents, and low cost for separation, extraction, and determination of Ibuprofen molecules.

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Acknowledgment

The authors are grateful to Kazerun Branch, Islamic Azad University Research Council for financial support of this project.

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  1. Department of Chemistry, Kazerun Branch, Islamic Azad University, Kazerun, Iran

    L. Sheikhian & E. Zahedinejad

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  1. L. Sheikhian
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  2. E. Zahedinejad
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Correspondence to L. Sheikhian.

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Sheikhian, L., Zahedinejad, E. Dispersive Solid Phase Extraction/Back-Extraction Using Carbon Nanotubes as Sorbent for HPLC/UV Determination of Ibuprofen in Human Blood Serum Samples. Pharm Chem J 57, 1827–1832 (2024). https://doi.org/10.1007/s11094-024-03085-2

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