We studied the expression of insulin-like growth factor 1 (IGF-1), androgen receptor (AR) and luteinizing hormone receptor (LHR) in the ovaries under the conditions of the modeling and subsequent treatment of functional ovarian cysts with gonadotropin-releasing hormone antagonist (ant-GnRH). The intensity of IGF-1, LHR, and AR expression in the generative elements of rat ovaries changed under conditions of functional ovarian cysts simulation, as well as during treatment with ant-GnRH. In both experimental groups, the expression levels of the studied markers in preantral follicles and epithelial lining of cysts were found to be related to the number of growing follicles and cysts. A divergence of LHR and AR expression indices and a more pronounced decrease in the number of cystic cavities were observed in the group receiving ant-GnRH. These changes demonstrate a positive effect of ant-GnRH on intra-ovarian regulatory factors and a therapeutic effect in functional ovarian cysts.
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References
Gasymova DM, Rukhlyada NN. Clinical and anamnestic characteristics of patients with complications of benign tumors and tumor-like masses of the ovary. Ross. Vestn. Akush. Gin. 2017;17(4):72-77. Russian. https://doi.org/10.17116/rosakush201717472-77
Volchenok DA, Tikhonovskaya OA, Logvinov SV, Mustafina LR. Expression of vascular endothelial growth factor during correction of experimental functional ovarian cysts. Morfologiya. 2019;156(6):88-89. Russian.
Bochkareva NV, Kondakova IV, Kolomiets LA, Muntyan AV. The system of insulin-like growth factors in pathogenesis and prognosis of epithelial ovarian cancer. Sib. Onkol. Zh. 2011;(3):74-81. Russian.
Andreeva EA, Khonina NA, Pasman NM, Chernykh ER. Cytokins in the regulation of ovarian folliculogenesis (a review). Probl. Reprod. 2017;23(1):8-14. Russian.
Volchenok DA, Tikhonovskaya OA, Okorokov AO, Mustafina LR, Timofeeva OS, Logvinov SV. Effects of bevacizumab on the regression of experimental functional cysts. Sib. Med. Obozr. 2018;(3):88-92. Russian. https://doi.org/10.20333/2500136-2018-3-88-92
Wimalarathne HAD, Wako H, Kawate N. Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers. J. Reprod. Dev. 2022;68(5):324-329. https://doi.org/10.1262/jrd.2022-018
Phoophitphong D, Srisuwatanasagul S, Tummaruk P. Immunohistochemical localization of luteinizing hormone receptor in the cyclic gilt ovary. Anat. Histol. Embryol. 2017;46(1):94-100. https://doi.org/10.1111/ahe.12255
Mazerbourg S, Monget P. Insulin-like growth factor binding proteins and IGFBP proteases: a dynamic system regulating the ovarian folliculogenesis. Front. Endocrinol. (Lausanne). 2018;9:134. https://doi.org/10.3389/fendo.2018.00134
Stubbs SA, Webber LJ, Stark J, Rice S, Margara R, Lavery S, Trew GH, Hardy K, Franks S. Role of Insulin-like growth factors in initiation of follicle growth in normal and polycystic human ovaries. J. Clin. Endocrinol. Metab. 2013;98(8):3298-3305. https://doi.org/10.1210/jc.2013-137
Logvinov SV, Tikhonovskaja OA, Petrova MS, Bukharina IJ, Petrov IA, Petrina JV, Okorokov AO, Alitkina ES. Patent RU No. 2282249. Method for modeling polycystic ovaries at predominance of follicular cysts. Bull. No. 23. Published August 20, 2006.
Baak JPA, Oort J. A Manual of Morphometry in Diagnostic Pathology. Springer Science & Business Media, 2012.
Dubrovina SO, Berlim YuD, Gimbut VS, Vovkochina MA. Hormone therapy for functional ovarian cysts. Akush. Gin. 2020;(4):210-213. Russian. https://doi.org/10.18565/aig.2020.4.210-213
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 9, pp. 391-394, September, 2023
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Timofeeva, O.S., Logvinov, S.V., Petrov, I.A. et al. Effect of Gonadotropin-Releasing Hormone Antagonist on the Expression Patterns of Insulin-Like Growth Factor 1, Androgen Receptor, and Luteinizing Hormone Receptor in an Experimental Rat Model of Functional Ovarian Cysts. Bull Exp Biol Med 176, 403–406 (2024). https://doi.org/10.1007/s10517-024-06033-y
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DOI: https://doi.org/10.1007/s10517-024-06033-y