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Leukoaraiosis is associated with poor outcomes after successful recanalization for large vessel occlusion stroke

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Abstract

Background

Leukoaraiosis (LA) is related to the dysfunction of the microcirculation and results in the impairment of the perfusion state. We investigated the association of LA and poor outcomes after successful recanalization by thrombectomy.

Methods

We retrospectively analyzed 97 patients with anterior large-artery occlusion who underwent thrombectomy and had successful recanalization (modified Treatment in Cerebral Ischemia Scale score 2b or 3). All patients underwent magnetic resonance imaging (MRI). LA was evaluated using fluid-attenuated inversion recovery MRI and graded using the Fazekas scale. Poor functional outcome at day 90 and symptomatic intracerebral hemorrhage (sICH) were compared between patients with absent to mild LA and moderate to severe LA. Logistic regression analyses were performed to determine the association of LA severity and outcomes.

Results

Moderate and severe LA occurred in 28.9% and 26.8% patients respectively. A higher proportion of poor outcomes were observed in patients with moderate to severe LA compared to patients with absent to mild LA (77.8% vs. 39.5%, p < 0.001). Logistic regression analyses showed patients with moderate to severe LA had 3.77 times (95%CI 1.21–11.76, p = 0.022) higher risk of having poor outcomes compared to patients with absent to mild LA.

Conclusions

LA severity may be associated with poor outcomes after successful recanalization for ischemic stroke with anterior large vessel occlusion.

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Funding

Nan**g Commission of Health and Family Planning, China (grant number ZDX16002) funded this study.

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Authors and Affiliations

  1. Department of Neurology, Nan**g First Hospital, Nan**g Medical University, No. 68 Changle Road, Nan**g, Jiangsu Province, 210006, People’s Republic of China

    Yukai Liu, Pengyu Gong, Huanhuan Sun, Shuting Zhang, Junshan Zhou & Yingdong Zhang

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  1. Yukai Liu
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  2. Pengyu Gong
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  3. Huanhuan Sun
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  4. Shuting Zhang
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  5. Junshan Zhou
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Correspondence to Junshan Zhou or Yingdong Zhang.

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The authors declare that they have no conflicts of interest.

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All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and national research committee and adhered to the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Liu, Y., Gong, P., Sun, H. et al. Leukoaraiosis is associated with poor outcomes after successful recanalization for large vessel occlusion stroke. Neurol Sci 40, 585–591 (2019). https://doi.org/10.1007/s10072-018-3698-2

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  • DOI: https://doi.org/10.1007/s10072-018-3698-2

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