Abstract
Synthesis of heteroannulated pyrano[3,2-c]quinolones was established starting from the reaction of 4-hydroxyquinolin-2-ones with ethene-1,2,3,4-tetracarbonitrile. Several conditions were carried out, and the corresponding product yields were illustrated. The neutral and non-polar condition was the best procedure for product formation. The structure of products was elucidated by NMR, IR, mass spectra, and elemental analysis. X-ray structure analysis was also used to elucidate the structure of the obtained products. The mechanism of products formation was also discussed.
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Acknowledgements
The authors thank DFG for providing Ashraf A. Aly with a fellowship, enabling him to conduct the compound analysis at the Karlsruhe Institute of Technology, Karlsruhe, Germany.
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Dedicated for the memory of Professor Dr. Raafat Mohamed Shaker.
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Aly, A.A., El-Naby, H.A.A., Ahmed, E.K. et al. Facile synthesis of new pyrano[3,2-c]quinolones via the reaction of quinolin-2-ones with ethene-1,2,3,4-tetracarbonitrile. Monatsh Chem 153, 277–284 (2022). https://doi.org/10.1007/s00706-022-02903-1
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DOI: https://doi.org/10.1007/s00706-022-02903-1