Abstract
An ionic liquid-based dispersive liquid–liquid microextraction (IL-DLLME) combined with magnetic solid-phase extraction (MSPE) was developed for extraction of quinolones (quinolones) from honey and milk prior to high-performance liquid chromatography (HPLC) analysis. 1-Butyl-3-methylimidazolium hexafluorophosphate was used as the extraction solvent and an effective adsorbent based on chitosan modified magnetic core–shell functionalized multi-walled carbon nanotube (MWCNTs-Fe3O4@SiO2-CS) nanoparticles was used to assist IL to adsorb quinolone residues in honey and milk samples. Extraction conditions were optimized through one-factor-at-a-time and response surface methodology using a Box-Behnken design. Under optimum conditions satisfactory linearity (R2 > 0.999) and high sensitivity (method limits of quantification were 4–8 μg kg−1 or μg L−1 in honey or milk samples) was achieved. The recoveries of quinolones in honey and milk ranged from 81.2 to 109%. Based on this study, the proposed method was employed for the determination of antibiotic residues in honey and milk samples.
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Acknowledgements
This work was supported by Hainan Provincial Philosophy and Social Science Planning Project (HNSK(YB)20-64), the Middle-aged Backbone Personnel Training Program of Shenyang Pharmaceutical University (ZQN2016011), Scientific Research Fund of Liaoning Provincial Education Department (2020LZD02), Inter-school Cooperation Project of General Undergraduate Universities in Liaoning Province (2020-181), and Project of Shenyang Key Laboratory of Functional Drug Carrier Materials (19-110-4-08).
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Hong, J., Liu, X., Yang, X. et al. Ionic liquid-based dispersive liquid–liquid microextraction followed by magnetic solid-phase extraction for determination of quinolones. Microchim Acta 189, 8 (2022). https://doi.org/10.1007/s00604-021-05077-5
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DOI: https://doi.org/10.1007/s00604-021-05077-5