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Preparation and highlighted applications of magnetic microparticles and nanoparticles: a review on recent advances

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Abstract

This review (with 144 refs.) focuses on the recent advances in the preparation and application of magnetic micro/nanoparticles. Specifically, it covers (a) methods for preparation (such as by coprecipitation, pyrolysis, hydrothermal, solvothermal, sol-gel, micro-emulsion, sonochemical, medium dispersing or emulsion polymerization methods), and (b) applications such as magnetic resonance imaging, magnetic separation of biomolecules (nucleic acids; proteins; cells), separation of metal ions and organic analytes, immobilization of enzymes, biological detection, magnetic catalysis and water treatment. Finally, the existing challenges and possible trends in the field are addressed.

This review focuses on the recent advances in the preparation and application of magnetic micro/nano particles. Finally, the existed problems and possible trends in the field were discussed.

a: Fe3O4@SiO2-PVAm: polyvinyl amine-coated Fe3O4@SiO2

b: CTS/MMT-Fe3O4 microsphere: chitosan/montmorillonite-Fe3O4 microsphere

c: MTAMs: magnetic targeted antibiotic microspheres

d: SM: the code of iron oxide-silica composite microspheres

e: PSt: poly styrene

f: gamma-PGA- PLA: poly(gamma-glutamic acid) and poly(lactide)

g: poly(-MMA–DVB–GMA) microspheres: poly(methylmethacrylate–divinylbenzene–glycidylmethacrylate) microspheres

h: AEAPS: N-(2-aminoethyl)-3-aminopropyltrimethoxysilane

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (Grant No. 81402899) and Shandong Provincial Natural Science Foundation, China (No. ZR2014HP020).

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  1. Department of Analytical Chemistry, China Pharmaceutical University, Nan**g, 210009, China

    Deli ** Bi

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  1. Deli **ao
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  2. Ting Lu
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  3. Rong Zeng
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  4. Yan** Bi
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Correspondence to Yan** Bi.

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The authors declare that they have no conflict of interest. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. Informed consent was obtained from all individual participants included in the study.

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Deli **ao and Ting Lu equally contributed to this work and should be considered co-first authors.

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**ao, D., Lu, T., Zeng, R. et al. Preparation and highlighted applications of magnetic microparticles and nanoparticles: a review on recent advances. Microchim Acta 183, 2655–2675 (2016). https://doi.org/10.1007/s00604-016-1928-y

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