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Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans

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Abstract

Background

A previous brain imaging study demonstrated activation of the right dorsolateral prefrontal cortex (DLPFC) during visceral nociception, and this activation was associated with anxiety. We hypothesized that functional modulation of the right DLPFC by repetitive transcranial magnetic stimulation (rTMS) can reveal the actual role of right DLPFC in brain–gut interactions in humans.

Methods

Subjects were 11 healthy males aged 23.5 ± 1.4 (mean ± SE) years. Viscerosensory evoked potential (VEP) with sham (0 mA) or actual (30 mA) electrical stimulation (ES) of the rectum was taken after sham, low frequency rTMS at 0.1 Hz, and high frequency rTMS at 10 Hz to the right DLPFC. Rectal tone was measured with a rectal barostat. Visceral perception and emotion were analyzed using an ordinate scale, rectal barostat, and VEP.

Key results

Low frequency rTMS significantly reduced anxiety evoked by ES at 30 mA (p < 0.05). High frequency rTMS–30 mA ES significantly produced more phasic volume events than sham rTMS–30 mA ES (p < 0.05).

Conclusions and inferences

We successfully modulated the gastrointestinal function of healthy individuals through rTMS to the right DLPFC. Thus, rTMS to the DLPFC appears to modulate the affective, but not direct, component of visceral perception and motility of the rectum.

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Abbreviations

IBS:

Irritable bowel syndrome

rTMS:

Repetitive transcranial magnetic stimulation

DLPFC:

Dorsolateral prefrontal cortex

VEP:

Viscerosensory evoked potential

EEG:

Electroencephalogram

References

  1. Drossman DA. The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006;130:1377–90.

    Article  PubMed  Google Scholar 

  2. Gralnek IM, Hays RD, Kilbourne A, Naliboff B, Mayer EA. The impact of irritable bowel syndrome on health-related quality of life. Gastroenterology. 2000;119:654–60.

    Article  PubMed  CAS  Google Scholar 

  3. Amouretti M, Le Pen C, Gaudin AF, Bommelaer G, Frexinos J, Ruszniewski P, et al. Impact of irritable bowel syndrome (IBS) on health-related quality of life (HRQOL). Gastroenterol Clin Biol. 2006;30:241–6.

    Article  PubMed  Google Scholar 

  4. Park JM, Choi MG, Kim YS, Choi CH, Choi SC, Hong SJ, et al. Quality of life of patients with irritable bowel syndrome in Korea. Qual Life Res. 2009;18:435–46.

    Article  PubMed  Google Scholar 

  5. Gralnek IM, Hays RD, Kilbourne AM, Chang L, Mayer EA. Racial differences in the impact of irritable bowel syndrome on health-related quality of life. J Clin Gastroenterol. 2004;38:782–9.

    Article  PubMed  Google Scholar 

  6. Longstreth GF, Thompson WG, Chey WD, Houghton LA, Mearin F, Spiller RC. Functional bowel disorders. Gastroenterology. 2006;130:1480–91.

    Article  PubMed  Google Scholar 

  7. Saito YA, Schoenfeld P, Locke GR 3rd. The epidemiology of irritable bowel syndrome in North America: a systematic review. Am J Gastroenterol. 2002;97:1910–5.

    PubMed  Google Scholar 

  8. Kang JY. Systematic review: the influence of geography and ethnicity in irritable bowel syndrome. Aliment Pharmacol Ther. 2005;21:663–76.

    Article  PubMed  CAS  Google Scholar 

  9. Kanazawa M, Endo Y, Whitehead WE, Kano M, Hongo M, Fukudo S. Patients and nonconsulters with irritable bowel syndrome reporting a parental history of bowel problems have more impaired psychological distress. Dig Dis Sci. 2004;49:1046–53.

    Article  PubMed  Google Scholar 

  10. Locke GR 3rd, Yawn BP, Wollan PC, Melton LJ 3rd, Lydick E, Talley NJ. Incidence of a clinical diagnosis of the irritable bowel syndrome in a United States population. Aliment Pharmacol Ther. 2004;19:1025–31.

    Article  PubMed  Google Scholar 

  11. Fukudo S, Nomura T, Muranaka M, Taguchi F. Brain–gut response to stress and cholinergic stimulation in irritable bowel syndrome. A preliminary study. J Clin Gastroenterol. 1993;17:133–41.

    Article  PubMed  CAS  Google Scholar 

  12. Mayer EA, Naliboff BD, Chang L, Coutinho SV. Stress and irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol. 2001;280:G519–24.

    PubMed  CAS  Google Scholar 

  13. Fukudo S, Suzuki J. Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome. Tohoku J Exp Med. 1987;151:373–85.

    Article  PubMed  CAS  Google Scholar 

  14. Fukudo S, Kanazawa M, Kano M, Sagami Y, Endo Y, Utsumi A, et al. Exaggerated motility of the descending colon with repetitive distention of the sigmoid colon in patients with irritable bowel syndrome. J Gastroenterol. 2002;37:145–50.

    Article  PubMed  Google Scholar 

  15. Whitehead WE, Crowell MD, Robinson JC, Heller BR, Schuster MM. Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction. Gut. 1992;33:825–30.

    Article  PubMed  CAS  Google Scholar 

  16. Chang L, Toner BB, Fukudo S, Guthrie E, Locke GR, Norton NJ, et al. Gender, age, society, culture, and the patient’s perspective in the functional gastrointestinal disorders. Gastroenterology. 2006;130:1435–46.

    Article  PubMed  Google Scholar 

  17. Bueno L, Fioramonti J, Delvaux M, Frexinos J. Mediators and pharmacology of visceral sensitivity: from basic to clinical investigations. Gastroenterology. 1997;112:1714–43.

    Article  PubMed  CAS  Google Scholar 

  18. Whitehead WE, Delvaux M. Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. The working team of Glaxo-Wellcome Research, UK. Dig Dis Sci. 1997;42:223–41.

    Article  PubMed  CAS  Google Scholar 

  19. Bouin M, Plourde V, Boivin M, Riberdy M, Lupien F, Laganière M, et al. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology. 2002;122:1771–7.

    Article  PubMed  Google Scholar 

  20. Sagami Y, Shimada Y, Tayama J, Nomura T, Satake M, Endo Y, et al. Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Gut. 2004;53:958–64.

    Article  PubMed  CAS  Google Scholar 

  21. Kanazawa M, Endo M, Yamaguchi K, Hamaguchi T, Whitehead WE, Itoh M, et al. Classical conditioned response of rectosigmoid motility and regional cerebral activity in humans. Neurogastroenterol Motil. 2005;17:705–13.

    Article  PubMed  CAS  Google Scholar 

  22. Dsmdt JE. Somatosensory CEP in man. In: Cobb WA, editor. Handbook of electrosensory and neurophysiology. Amsterdam: Elsevier; 1971. p. 55–82.

    Google Scholar 

  23. Hollerbach S, Kamath MV, Chen Y, Fitzpatrick D, Upton AR, Tougas G. The magnitude of the central response to esophageal electrical stimulation is intensity dependent. Gastroenterology. 1997;112:1137–46.

    Article  PubMed  CAS  Google Scholar 

  24. Hobson AR, Sarkar S, Furlong PL, Thompson DG, Aziz Q. A cortical evoked potential study of afferents mediating human esophageal sensation. Am J Physiol Gastrointest Liver Physiol. 2000;279:G139–47.

    PubMed  CAS  Google Scholar 

  25. Kanazawa M, Nomura T, Fukudo S, Hongo M. Abnormal visceral perception in patients with functional dyspepsia: use of cerebral potentials evoked by electrical stimulation of the oesophagus. Neurogastroenterol Motil. 2000;12:87–94.

    Article  PubMed  CAS  Google Scholar 

  26. Fukudo S, Kotake C, Kanazawa M, Sagami Y, Nomura T, Hongo M. Exaggerated viscerosensory evoked potentials in irritable bowel syndrome (abstract). Gastroenterology. 2001;120:A4032.

    Google Scholar 

  27. Bromm B, Lorenz J. Neurophysiological evaluation of pain. Electroencephalogr Clin Neurophysiol. 1998;107:227–53.

    Article  PubMed  CAS  Google Scholar 

  28. Kanazawa M, Fukudo S, Nomura T, Hongo M. Electrophysiological correlates of personality influences in visceral perception. JAMA. 2001;286:1974–5.

    Article  PubMed  CAS  Google Scholar 

  29. Watanabe S, Hattori T, Kanazawa M, Kano M, Fukudo S. Role of histaminergic neurons in hypnotic modulation of brain processing of visceral perception. Neurogastroenterol Motil. 2007;19:831–8.

    Article  PubMed  CAS  Google Scholar 

  30. Barker AT. The history and basic principles of magnetic nerve stimulation. Electroencephalogr Clin Neurophysiol Suppl. 1999;51:3–21.

    PubMed  CAS  Google Scholar 

  31. Barker AT, Jalinous R, Freeston IL. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985;1:1106–7.

    Article  PubMed  CAS  Google Scholar 

  32. Epstein CM, Schwartzberg DG, Davey KR, Sudderth DB. Localizing the site of magnetic brain stimulation in humans. Neurology. 1990;40:666–70.

    PubMed  CAS  Google Scholar 

  33. Paus T, Barrett J. Transcranial magnetic stimulation (TMS) of the human frontal cortex: implications for repetitive TMS treatment of depression. J Psychiatry Neurosci. 2004;29:268–79.

    PubMed  Google Scholar 

  34. Fitzgerald PB, Brown T, Marston NAU, Daskalakis ZJ, Kularni J. A double-blind placebo controlled trial of transcranial magnetic stimulation in the treatment of depression. Arch Gen Pschiatry. 2003;60:1002–8.

    Article  Google Scholar 

  35. Fitzgerald PB, Benitez J, de Castella A, Daskalakis ZJ, Brown TL, Kulkarni J. A randomized, controlled trial of sequential bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression. Am J Psychiatry. 2006;163:88–94.

    Article  PubMed  Google Scholar 

  36. Grunhaus L, Dannon PN, Schreiber S, Dolberg OH, Amiaz R, Ziv R, et al. Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study. Biol Psychiatry. 2000;47:314–24.

    Article  PubMed  CAS  Google Scholar 

  37. Isenberg K, Downs D, Pierce K, Svarakic D, Garcia K, Jarvis M, et al. Low frequency rTMS stimulation of the right frontal cortex is as effective as high frequency rTMS stimulation of the left frontal cortex for antidepressant-free, treatment-resistant depressed patients. Ann Clin Psychiatry. 2005;17:153–9.

    Article  PubMed  Google Scholar 

  38. Herrmann LL, Ebmeier KP. Factors modifying the efficacy of transcranial magnetic stimulation in the treatment of depression: a review. J Clin Psychiatry. 2006;67:1870–6.

    Article  PubMed  Google Scholar 

  39. O’Reardon JP, Solvason HB, Janicak PG, Sampson S, Isenberg KE, Nahas Z, et al. Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol Psychiatry. 2007;62:1208–16.

    Article  PubMed  Google Scholar 

  40. Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, et al. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science. 2004;303:1162–7.

    Article  PubMed  CAS  Google Scholar 

  41. Terui T, Watanabe S, Kanazawa M, Hamaguchi T, Mine H, Yanai K, et al. Differential modulation of the regional brain by hypnotic suggestion between patients with irritable bowel syndrome, healthy subjects. Gastroenterology. 2007;132:A134.

    Google Scholar 

  42. Hamaguchi T, Kano M, Rikimaru H, Kanazawa M, Itoh M, Yanai K, et al. Brain activity during distention of the descending colon in humans. Neurogastroenterol Motil. 2004;16:299–309.

    Article  PubMed  CAS  Google Scholar 

  43. Kanazawa M, Endo M, Yamaguchi K, Hamaguchi T, Whitehead WE, Itoh M, et al. Classical conditioned response of rectosigmoid motility and regional cerebral activity in humans. Neurogastroenterol Motil. 2005;17:705–13.

    Article  PubMed  CAS  Google Scholar 

  44. Talairach J, Tournoux P. Co-planar stereotaxic atlas of the human brain. New York: Thieme Medical Publishers; 1988.

    Google Scholar 

  45. Fukudo S, Nomura T, Hongo M. Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut. 1998;42:845–9.

    Article  PubMed  CAS  Google Scholar 

  46. Sloots CE, Felt-Bersma RJ, Meuwissen SG, Kuipers EJ. Influence of gender, parity, and caloric load on gastrorectal response in healthy subjects: a barostat study. Dig Dis Sci. 2003;48:516–21.

    Article  PubMed  Google Scholar 

  47. Bell AM, Pemberton JH, Hanson RB, Zinsmeister AR. Variations in muscle tone of the human rectum: recordings with an electromechanical barostat. Am J Physiol. 1991;260:G17–25.

    PubMed  CAS  Google Scholar 

  48. Whitehead WE, Delvaux M. Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. The Working Team of Glaxo-Wellcome Research, UK. Dig Dis Sci. 1997;42:223–41.

    Article  PubMed  CAS  Google Scholar 

  49. Von der Ohe MR, Hanson RB, Camilleri M. Comparison of simultaneous recordings of human colonic contractions by manometry and a barostat. Neurogastroenterol Motil. 1994;6:213–22.

    Google Scholar 

  50. Jasper HH. Formal discussion: dendrites. Electroencephalogr Clin Neurophysiol. 1958;10:42–50.

    Google Scholar 

  51. Aziz Q, Furlong PL, Barlow J, Hobson A, Alani S, Bancewicz J, et al. Topographic map** of cortical potentials evoked by distension of the human proximal and distal oesophagus. Electroencephalogr Clin Neurophysiol. 1995;96:219–28.

    Article  PubMed  CAS  Google Scholar 

  52. Hamdy S, Rothwell JC, Aziz Q, Singh KD, Thompson DG. Long-term reorganization of human motor cortex driven by short-term sensory stimulation. Nat Neurosci. 1998;1:64–8.

    Article  PubMed  CAS  Google Scholar 

  53. Hamdy S, Aziz Q, Rothwell JC, Singh KD, Barlow J, Hughes DG, et al. The cortical topography of human swallowing musculature in health and disease. Nat Med. 1996;2:1217–24.

    Article  PubMed  CAS  Google Scholar 

  54. Hoffman RE, Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. Am J Psychiatry. 2002;159:1093–102.

    Article  PubMed  Google Scholar 

  55. Ogawa A, Ukai S, Shinosaki K, Yamamoto M, Kawaguchi S, Ishii R, et al. Slow repetitive transcranial magnetic stimulation increases somatosensory high-frequency oscillations in humans. Neurosci Lett. 2004;358:193–6.

    Article  PubMed  CAS  Google Scholar 

  56. Sokhadze E, Baruth J, Tasman A, Mansoor M, Ramaswamy R, Sears L, et al. Low-frequency repetitive transcranial magnetic stimulation (rTMS) affects event-related p measures of novelty processing in autism. Appl Psychophysiol Biofeedback. 2010;35:147–61.

    Article  PubMed  Google Scholar 

  57. Kimbrell TA, Kimbrell TA, Little JT, Dunn RT, Frye MA, Greenberg BD, et al. Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol Psychiatry. 1999;46:1603–13.

    Article  PubMed  CAS  Google Scholar 

  58. Speer AM, Kimbrell TA, Wassermann EM D, Repella J, Willis MW, Herscovitch P, et al. Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol Psychiatry. 2000;48:1133–41.

    Article  PubMed  CAS  Google Scholar 

  59. Nitschke JB, Sarinopoulos I, Mackiewicz KL, Schaefer HS, Davidson RJ. Functional neuroanatomy of aversion and its anticipation. Neuroimage. 2006;29:106–16.

    Article  PubMed  Google Scholar 

  60. Rauch SL, Savage CR, Alpert NM, Fischman AJ, Jenike MA. The functional neuroanatomy of anxiety: a study of three disorders using positron emission tomography and symptom provocation. Biol Psychiatry. 1997;42:446–52.

    Article  PubMed  CAS  Google Scholar 

  61. Dalton KM, Kalin NH, Grist TM, Davidson RJ. Neural-cardiac coupling in threat-evoked anxiety. J Cogn Neurosci. 2005;17:969–80.

    Article  PubMed  Google Scholar 

  62. Grimm S, Beck J, Schuepbach D, Hell D, Boesiger P, Bermpohl F, et al. Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol Psychiatry. 2008;63:369–76.

    Article  PubMed  Google Scholar 

  63. Baxter LR Jr, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, et al. Reduction in left prefrontal cortex glucose metabolism common to three types of depression. Arch Gen Psychiatry. 1989;46:243–50.

    PubMed  CAS  Google Scholar 

  64. Buchsbaum MS, Wu J, DeLisi LE, Holcomb H, Kessler R, Johnson J, et al. Frontal cortex and basal ganglia rates assessed by positron emission tomography with (fluorine-18) 2-deoxyglucose in affective illness. J Affect Dis. 1986;10:137–52.

    Article  PubMed  CAS  Google Scholar 

  65. Drevets WC, Price JL, Simpson JR Jr, Todd RD, Reich T, Vannier M, et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature. 1997;386:824–7.

    Article  PubMed  CAS  Google Scholar 

  66. Drevets WC, Videen TO, Preskorn SH, Preskorn SH, Carmichael ST, Raichle ME. A functional neuroanatomical study of unipolar depression. J Neurosci. 1992;12:3628–41.

    PubMed  CAS  Google Scholar 

  67. George MS, Ketter TA, Post RM. Prefrontal cortex dysfunction in clinical depression. Depression. 1994;2:59–72.

    Article  Google Scholar 

  68. Martinot JL, Hardy P, Feline A, Huret JD, Mazoyer B, Attar-Levy D, et al. Left prefrontal glucose hypometabolism in the depressed state: a confirmation. Am J Psychiatry. 1990;147:1313–7.

    PubMed  CAS  Google Scholar 

  69. Avery DH, Holtzheimer PE III, Fawaz W, Russo J, Neumaier J, Dunner DL, et al. A controlled study of repetitive transcranial stimulation in medication-resistant major depression. Biol Psychiatry. 2006;59:187–94.

    Article  PubMed  Google Scholar 

  70. George MS, Wassermann EM, Williams WA, Callahan A, Ketter TA, Basser P, et al. Daily repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. Neuroreport. 1995;6:1853–6.

    Article  PubMed  CAS  Google Scholar 

  71. George MS, Wassermann EM, Kimbrell TA, Little JT, Williams WE, Danielson AL, et al. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: a placebo controlled crossover trial. Am J Psychiatry. 1997;154:1752–6.

    PubMed  CAS  Google Scholar 

  72. Pascual-Leone A, Rubio B, Pallardó F, Catalá MD. Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet. 1996;348:233–7.

    Article  PubMed  CAS  Google Scholar 

  73. Rossini D, Lucca A, Zanardi R, Magri L, Smeraldi E. Transcranial magnetic stimulation in treatment-resistant depressed patients: a double-blind, placebo controlled trial. Psychiatry Res. 2005;137:1–10.

    Article  PubMed  Google Scholar 

  74. Kauffmann CD, Cheema MA, Miller BE. Slow right prefrontal transcranial magnetic stimulation as a treatment for medication-resistant depression: a double-blind, placebo-controlled study. Depress Anxiety. 2004;19:159–62.

    Article  Google Scholar 

  75. Schutter DJ, Laman DM, van Honk J, Vergouwen AC, Koerselman GF. Partial clinical response to 2 weeks of 2 Hz repetitive transcranial magnetic stimulation to the right parietal cortex in depression. Int J Neuropsychopharmacol. 2009;12:643–50.

    Article  PubMed  Google Scholar 

  76. Höppner J, Schulz M, Irmisch G, Mau R, Schläfke D, Richter J. Antidepressant efficacy of two different rTMS procedures. High frequency over left versus low frequency over right prefrontal cortex compared with sham stimulation. Eur Arch Psychiatry Clin Neurosci. 2003;253:103–9.

    PubMed  Google Scholar 

  77. Ressler KJ, Mayberg HS. Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nat Neurosci. 2007;10:1116–24.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This research was supported by a Grant-in-Aid for Scientific Research from Ministry of Education, Culture, Sports, Science and Technology and that of Health, Labour and Welfare, Japan.

Conflict of interest

Authors disclose no conflict of interest and there is no commercial bias in this study.

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Authors and Affiliations

  1. Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo, Aoba, Sendai, 980-8575, Japan

    Yuuichi Aizawa, Joe Morishita, Michiko Kano, Motoyori Kanazawa & Shin Fukudo

  2. Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Japan

    Takayuki Mori & Shin-Ichi Izumi

  3. Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Japan

    Kenichiro Tsutsui & Toshio Iijima

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  1. Yuuichi Aizawa
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Correspondence to Shin Fukudo.

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Aizawa, Y., Morishita, J., Kano, M. et al. Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans. J Gastroenterol 46, 1071–1080 (2011). https://doi.org/10.1007/s00535-011-0423-9

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