Dear Editorwe would like to share ideas on the publication “Neuropsychiatric post-acute sequelae of COVID-19: prevalence, severity, and impact of vaccination [1].” With regard to Egyptian COVID-19 survivors, Elmazny et al. sought to ascertain the prevalence and determinants of neuropsychiatric post-acute sequelae of the virus as well as the effects of complete immunization prior to COVID-19 infection on the occurrence and severity of these manifestations [1]. In this report, fatigue was identified as the most common neuropsychiatric sequelae in 36.5% of Egyptian COVID-19 survivors, according to Elmazny et al. [1]. According to Elmazny et al., the ability of COVID-19 vaccinations to lessen the severity of various post-COVID-19 neuropsychiatric manifestations may increase public support for vaccination.

Our shared opinion is that the current data may or may not suggest that immunizations are useful in lessening the severity of some post-COVID-19 neuropsychiatric symptoms. Any potential complicating factors must be taken into consideration. It's crucial to rule out the effects of co-morbidity and any underlying immunological or gynecological conditions before moving forward with any other steps. Asymptomatic COVID-19 should also be ruled out in patients who require specialized laboratory tests because it is relatively rare [2] which will help prevent incorrect diagnoses. The body's response to a vaccine can also be influenced by the underlying genetic component [3]. On these elements, more study is required.