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High-Performance liquid chromatographic separation of enantiomers of unusual amino acids possessing cycloalkane or cycloalkene skeletons on a chiral crown ether containing stationary phase

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Summary

Direct reversed-phase high-performance liquid chromatographic methods were developed for the separation and identification of the enantiomers of mono- and bicyclic racemic β-amino acids:cis- andtrans-2-aminocyclopentane-1-carboxylic acids,cis- andtrans-2-aminocyclohexane-1-carboxylic acids,cis- andtrans-2-amino-4-cyclohexene-1-carboxylic acids,diendo- anddiexo-3-aminobicyclo[2.2.1]heptane-2-carboxylic acids anddiendo- anddiexo-3-amino-5-bicyclo[2.2.1]heptene-2-carboxylic acids. Enantioseparation was carried out by the application of a chiral stationary phase, Crownpak CR(+). The conditions of separation were optimized by changing the temperature, the flow rate and the pH of the mobile phase.

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Authors and Affiliations

  1. Department of Inorganic and Analytical Chemistry, Attila József University, P.O. Box 440, 6701, Szeged, Hungary

    G. Török & A. Péter

  2. Institute of Pharmaceutical Chemistry, Albert Szent-Györgyi University, P.O. Box 121, 6701, Szeged, Hungary

    F. Fülöp

Authors
  1. G. Török
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  2. A. Péter
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  3. F. Fülöp
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Török, G., Péter, A. & Fülöp, F. High-Performance liquid chromatographic separation of enantiomers of unusual amino acids possessing cycloalkane or cycloalkene skeletons on a chiral crown ether containing stationary phase. Chromatographia 48, 20–26 (1998). https://doi.org/10.1007/BF02467510

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  • DOI: https://doi.org/10.1007/BF02467510

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