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Effect of oxygen and hypergravitation on alveolar surfactant

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The effect of prolonged (up to 66 h) exposures to pure oxygen and of brief (5 min) inhalation of oxygen combined with gravitational overloads produced by longitudinal acceleration (5g) on the surface tension and surface potential of the alveolar washings from the lungs of albino rats was studied. Under both experimental conditions atelectasis of the lungs was formed, with a decrease in the surface activity of the surfactant. The mechanisms of the changes in surfactant activity during hyperoxia, alone and combined with hypergravitation, are discussed.

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Authors
  1. M. A. Tikhonov
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  2. O. V. Petrov
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  3. A. V. Kondakov
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  4. E. V. Loginova
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Tikhonov, M.A., Petrov, O.V., Kondakov, A.V. et al. Effect of oxygen and hypergravitation on alveolar surfactant. Bull Exp Biol Med 86, 862–865 (1978). https://doi.org/10.1007/BF00801292

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  • DOI: https://doi.org/10.1007/BF00801292

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