SpringerLink
Log in

Synthesis and Membrane Transport of Serotonin in the Develo** Ovarian Follicle of Mouse

  • Biochemistry, Biophysics, and Molecular Biology
  • Published:
Doklady Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

Using RT-PCR, we showed the presence of Tph1 mRNA in follicular cells and Tph2 mRNA in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of Ddc expression, which indicates that serotonin cannot be synthesized in a develo** ovarian follicle. The membrane serotonin transporter Sert is expressed in follicular cells and oocytes. Experiments on the cultivation of follicles in vitro confirmed the absence of serotonin synthesis from 5-hydroxytryptophan and the presence of membrane transport activity in the oocyte.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Clausell, D.E. and Soliman, K.F., Experientia, 1978, vol. 34, no. 3, pp. 410–411.

    Article  CAS  PubMed  Google Scholar 

  2. Bódis, J., Bognár, Z., Hartmann, G., et al., Gynecol. Obstet. Invest., 1992, vol. 33, no. 3, pp. 165–167.

    Article  PubMed  Google Scholar 

  3. Dubé, F. and Amireault, P., Life Sci., 2007, vol. 81, nos. 25–26, pp. 1627–1637.

    Article  PubMed  Google Scholar 

  4. Bódis, J., Hartmann, G., Tinneberg, H.R., et al., Gynecol. Obstet. Invest., 1993, vol. 35, no. 4, pp. 232–235.

    Article  PubMed  Google Scholar 

  5. Tanaka, E., Baba, N., Toshida, K., et al., Life Sci., 1993, vol. 53, no. 7, pp. 563–570.

    Article  CAS  PubMed  Google Scholar 

  6. Sheng, Y., Wang, L., Liu, X.S.J., et al., J. Cell Physiol., 2005, vol. 202, no. 3, pp. 777–786.

    Article  CAS  PubMed  Google Scholar 

  7. Koppan, M., Bodis, J., Verzar, Z., et al., Endocrine, 2004, vol. 24, no. 2, pp. 155–159.

    Article  CAS  PubMed  Google Scholar 

  8. Graveleau, C., Paust, H.J., Schmidt-Grimminger, D., et al., J. Clin. Endocrinol. Metab., 2000, vol. 85, no. 3, pp. 1277–1286.

    CAS  PubMed  Google Scholar 

  9. Zha, W., Ho, H.T.B., Hu, T., et al., Sci. Rep., 2017, vol. 7, no. 1, p. 1137.

    Article  PubMed  PubMed Central  Google Scholar 

  10. Lister, A., Regan, C., Van Zwol, J., et al., Aquat. Toxicol., 2009, vol. 95, no. 4, pp. 320–329.

    Article  CAS  PubMed  Google Scholar 

  11. Basu, B., Desai, R., Balaji, J., et al., Reproduction, 2008, vol. 135, no. 5, pp. 657–669.

    Article  CAS  PubMed  Google Scholar 

  12. Amenta, F., Vega, J.A., Ricci, A., et al., Anat. Rec., 1992, vol. 233, no. 3, pp. 478–484.

    Article  CAS  PubMed  Google Scholar 

  13. Ugrumov, M.V., Melnikova, V.I., Lavrentyeva, A.V., et al., Neuroscience, 2004, vol. 124, no. 3, pp. 629–635.

    Article  CAS  PubMed  Google Scholar 

  14. Andreev, E., Brosseau, N., Carmona, E., et al., Sci. Rep., 2016, vol. 6, no. 20508.

    Google Scholar 

  15. Sitte, H.H., Hiptmair, B., Zwach, J., et al., Mol. Pharmacol., 2001, vol. 59, no. 5, pp. 1129–1137.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Koltzov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 119334, Russia

    D. A. Nikishin & Y. B. Shmukler

  2. Moscow State University, Moscow, 119992, Russia

    D. A. Nikishin & N. M. Alyoshina

Authors
  1. D. A. Nikishin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. M. Alyoshina
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. B. Shmukler
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. A. Nikishin.

Additional information

Original Russian Text © D.A. Nikishin, N.M. Alyoshina, Y.B. Shmukler, 2018, published in Doklady Akademii Nauk, 2018, Vol. 478, No. 1, pp. 103–106.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nikishin, D.A., Alyoshina, N.M. & Shmukler, Y.B. Synthesis and Membrane Transport of Serotonin in the Develo** Ovarian Follicle of Mouse. Dokl Biochem Biophys 478, 4–7 (2018). https://doi.org/10.1134/S1607672918010027

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1607672918010027

Search

Navigation