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Determination of carbamazepine in formulation samples using dispersive liquid–liquid microextraction method followed by ion mobility spectrometry

  • Original Research
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International Journal for Ion Mobility Spectrometry

Abstract

A simple, sensitive, fast and efficient method based on dispersive liquid–liquid microextraction (DLLME) followed by ion mobility spectrometry (IMS) has been proposed for preconcentration and trace detection of carbamazepine (CBZ) in formulation samples. In this method, 1 mL of methanol (disperser solvent) containing 80 μL of chloroform (extraction solvent) was rapidly injected by a syringe into a sample. After 5 min centrifugation, the preconcentrated carbamazepine in the organic phase was determined by IMS. Development of DLLME procedure includes optimization of parameters influencing the extraction efficiencies such as kind and volume of extraction solvent, disperser solvent and salt addition, centrifugation time and pH of the sample solution. The proposed method presented good linearity in the range of 0.05–10 μg mL−1 and the detection limit was 0.025 μg mL−1. The repeatability of the method expressed as relative standard deviation was 6 % (n = 5). This method has been applied to the analysis of carbamazepine formulation samples with satisfactory relative recoveries ≤75 %.

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Acknowledgments

This work was supported with grants from Zanjan University Research Council.

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Authors and Affiliations

  1. Phase Equilibria Research Laboratory, Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, 45371-38791, Iran

    Hamideh Kalhor, Siamak Hashemipour & Mohammad Reza Yaftian

  2. Department of Chemistry, Boroujerd Branch, Islamic Azad University, Boroujerd, Iran

    Parvin Shahdousti

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  1. Hamideh Kalhor
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  2. Siamak Hashemipour
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  3. Mohammad Reza Yaftian
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  4. Parvin Shahdousti
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Correspondence to Hamideh Kalhor.

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Kalhor, H., Hashemipour, S., Yaftian, M.R. et al. Determination of carbamazepine in formulation samples using dispersive liquid–liquid microextraction method followed by ion mobility spectrometry. Int. J. Ion Mobil. Spec. 19, 51–56 (2016). https://doi.org/10.1007/s12127-015-0184-x

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  • DOI: https://doi.org/10.1007/s12127-015-0184-x

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