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Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo

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Abstract

A multifunctional, dual-drug carrier platform was successfully constructed. Core-shell structured NaGdF4:Yb/Er@NaGdF4:Yb@mSiO2-polyethylene glycol (abbreviated as UCNPS) nanoparticles loaded with the antitumor drug, doxorubicin (DOX) were incorporated into poly(ɛ-caprolactone) (PCL) and gelatin loaded with antiphlogistic drug, indomethacin (MC) to form nanofibrous fabrics (labeled as MC/UCNPS/DOX) via electrospinning process. The resultant multifunctional spinning pieces can be surgically implanted directly at the tumor site of mice as an orthotopic chemotherapy by controlled-release DOX from mesoporous silicon dioxide (SiO2) and upconversion fluorescence/magnetic resonance dual-model imaging through NaGdF4:Yb/Er@NaGdF4:Yb embedded in MC/UCNPS/DOX in vivo.

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Authors and Affiliations

  1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130024, China

    Yinyin Chen, Zhiyao Hou, **an Ma, Dongmei Yang, Chunxia Li & Jun Lin

  2. University of the Chinese Academy of Sciences, Bei**g, 100049, China

    Yinyin Chen, Shi Liu & Dongmei Yang

  3. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130024, China

    Shi Liu

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  1. Yinyin Chen
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  2. Shi Liu
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  3. Zhiyao Hou
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  4. **an Ma
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  5. Dongmei Yang
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  6. Chunxia Li
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  7. Jun Lin
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Correspondence to Chunxia Li or Jun Lin.

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Chen, Y., Liu, S., Hou, Z. et al. Multifunctional electrospinning composite fibers for orthotopic cancer treatment in vivo . Nano Res. 8, 1917–1931 (2015). https://doi.org/10.1007/s12274-014-0701-y

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  • DOI: https://doi.org/10.1007/s12274-014-0701-y

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