Abstract
Objective
To study the etiological profile and patterns of clinical presentations of urolithiasis (UL) in children.
Methods
This observational study included patients <18 y with UL, who were referred to the pediatric nephrology clinic. Clinical features, family history, consanguinity and estimated glomerular filtration rate (eGFR) at presentation and follow-up were recorded. The children were evaluated using relevant blood and urine investigations.
Results
A total of 72 children with UL were evaluated for the study. The etiology of UL (n = 72) included hyperoxaluria (n = 25; 34.7%), idiopathic hypercalciuria (n = 21; 29.2%), idiopathic hyperuricosuria (n = 3; 4.2%), cystinuria (n = 3; 4.2%), urate transporter defect (n = 2; 2.8%) and mixed stones (predominant component calcium oxalate) (n = 9; 12.5%). No etiology was detected in 4 cases (5.5%). Common presenting complaints included flank pain (n = 41; 56.7%), hematuria (n = 29; 40.3%), urinary tract infection (UTI) (n = 29; 40.3%) and vomiting (n = 11; 15.3%). The median age of presentation was 60 (36, 96) mo. Family history and consanguinity were present in 30 cases (41.7%) and 28 cases (38.9%) respectively. Stone analysis was done in 20 cases, of which 9 cases were mixed stones (predominant calcium oxalate) and 6 were calcium oxalate stones.
Conclusions
Among children with urolithiasis, hyperoxaluria, idiopathic hypercalciuria, idiopathic hyperuricosuria, and cystinuria were the predominant identifiable entities, together accounting for 72% of cases; and renal colic, hematuria and UTI were the commonest clinical complaints.
Similar content being viewed by others
References
Copelovitch L. Urolithiasis in children: medical approach. Pediatr Clin N Am. 2012;59:881–96.
Gajengi AKR, Wagaskar VG, Tanwar HV, et al. Metabolic evaluation in paediatric urolithiasis: a 4-year open prospective study. J Clin Diagn Res. 2016;10:PC04–6.
Abhishek, Kumar J, Mandhani A, et al. Pediatric urolithiasis: experience from a tertiary referral center. J Pediatr Urol. 2013;9:825–30.
Gouru VR, Pogula VR, Vaddi SP, Manne V, Byram R, Kadiyala LS. Metabolic evaluation of children with urolithiasis. Urol Ann. 2018;10:94–9.
Kapadia T, Vani SN. Urolithiasis in childhood. Indian J Pediatr. 1991;58:671–4.
Schwartz GJ, Work DF. Measurement and estimation of GFR in children and adolescents. Clin J Am Soc Nephrol. 2009;4:1832–43.
Mantan M, Bagga A, Virdi VS, Menon S, Hari P. Etiology of nephrocalcinosis in northern Indian children. Pediatr Nephrol. 2007;22:829–33.
Cameron MA, Sakhaee K, Moe OW. Nephrolithiasis in children. Pediatr Nephrol. 2005;20:1587–92.
Habbig S, Beck BB, Hoppe B. Nephrocalcinosis and urolithiasis in children. Kidney Int. 2011;80:1278–91.
Borghi L, Meschi T, Amato F, Briganti A, Novarini A, Giannini A. Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. J Urol. 1996;155:839–43.
Nouvenne A, Meschi T, Prati B, et al. Effects of a low-salt diet on idiopathic hypercalciuria in calcium-oxalate stone formers: a 3-mo randomized controlled trial. Am J Clin Nutr. 2010;91:565–70.
Siener R, Ebert D, Nicolay C, Hesse A. Dietary risk factors for hyperoxaluria in calcium oxalate stone formers. Kidney Int. 2003;63:1037–43.
Yang D, Tiselius H-G, Lan C, et al. Metabolic disturbances in Chinese children with urolithiasis: a single center report. Urolithiasis. 2017;45:285–90.
Kamoun A, Daudon M, Abdelmoula J, et al. Urolithiasis in Tunisian children: a study of 120 cases based on stone composition. Pediatr Nephrol. 1999;13:920–5.
Sarkissian A, Babloyan A, Arikyants N, Hesse A, Blau N, Leumann E. Pediatric urolithiasis in Armenia: a study of 198 patients observed from 1991 to 1999. Pediatr Nephrol. 2001;16:728–32.
Knoll T, Schubert AB, Fahlenkamp D, Leusmann DB, Wendt-Nordahl G, Schubert G. Urolithiasis through the ages: data on more than 200,000 urinary stone analyses. J Urol. 2011;185:1304–11.
Nicoletta JA, Lande MB. Medical evaluation and treatment of urolithiasis. Pediatr Clin N Am. 2006;53:479–91.
Tanaka ST, Pope JC. Pediatric stone disease. Curr Urol Rep. 2009;10:138–43.
Author information
Authors and Affiliations
Contributions
KR, SK, RM, PS, BKN and PK were involved in management of the patients. KR collected the data, reviewed the literature and drafted the first version of the manuscript. SK conceptualized the study, reviewed the literature, revised the manuscript and critically reviewed the manuscript. RM and BKN were involved in surgical management of the cases. All authors contributed to drafting of the manuscript and approved the final version of the manuscript. SK shall act as guarantor of the paper.
Corresponding author
Ethics declarations
Conflict of Interest
None.
Source of Funding
Supported, in part, by institutional and departmental funds.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Ramya, K., Krishnamurthy, S., Manikandan, R. et al. Metabolic and Clinical Characteristics of Children with Urolithiasis from Southern India. Indian J Pediatr 88, 345–350 (2021). https://doi.org/10.1007/s12098-020-03455-0
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-020-03455-0