Abstract
This retrospective survey examines the etiology of nephrocalcinosis (NC) in 40 patients (26 boys), over an 8-year period. The median age at onset of symptoms and presentation was 36 months and 72 months, respectively. Clinical features included marked failure to thrive (82.5%), polyuria (60%) and bony deformities (52.5%). The etiology of NC included distal renal tubular acidosis (RTA) in 50% patients and idiopathic hypercalciuria and hyperoxaluria in 7.5% each. Other causes were Bartter syndrome, primary hypomagnesemia with hypercalciuria, severe hypothyroidism and vitamin D excess. No cause for NC was found in 12.5% patients. Specific therapy, where possible, ameliorated the biochemical aberrations, although the extent of NC remained unchanged. At a median (range) follow up of 35 (14–240) months, glomerular filtration rate (GFR) had declined from 82.0 (42–114) ml/min per 1.73 m2 body surface area to 70.8 (21.3–126.5) ml/min per 1.73 m2 body surface area (P = 0.001). Our findings confirm that, even with limited diagnostic facilities, protocol-based evaluation permits determination of the etiology of NC in most patients.
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Mantan, M., Bagga, A., Virdi, V.S. et al. Etiology of nephrocalcinosis in northern Indian children. Pediatr Nephrol 22, 829–833 (2007). https://doi.org/10.1007/s00467-006-0425-7
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DOI: https://doi.org/10.1007/s00467-006-0425-7