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Therapeutic “Tool” in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair

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Abstract

Repairing osteochondral defects to restore joint function is a major challenge in regenerative medicine. However, with recent advances in tissue engineering, the development of potential treatments is promising. In recent years, in addition to single-layer scaffolds, double-layer or multilayer scaffolds have been prepared to mimic the structure of articular cartilage and subchondral bone for osteochondral repair. Although there are a range of different cells such as umbilical cord stem cells, bone marrow mesenchyml stem cell, and others that can be used, the availability, ease of preparation, and the osteogenic and chondrogenic capacity of these cells are important factors that will influence its selection for tissue engineering. Furthermore, appropriate cell proliferation and differentiation of these cells is also key for the optimal repair of osteochondral defects. The development of bioreactors has enhanced methods to stimulate the proliferation and differentiation of cells. In this review, we summarize the recent advances in tissue engineering, including the development of layered scaffolds, cells, and bioreactors that have changed the approach towards the development of novel treatments for osteochondral repair.

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Funding

This work was supported by the National Natural Science Foundation of China (31670978/31370991/21676041), the Fok Ying Tung Education Foundation (132027), the State Key Laboratory of Fine Chemicals (KF1111) and the Natural Science Foundation of Liaoning (20180510028).

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Authors and Affiliations

  1. State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian, 116024, China

    Xueyan Hu, Jie Xu, Wenfang Li, Liying Li, Tianqing Liu & Kedong Song

  2. Key Laboratory of Biological Medicines, Universities of Shandong Province Weifang Key Laboratory of Antibody Medicines, School of Bioscience and Technology, Weifang Medical University, Weifang, 261053, China

    Wenfang Li

  3. Burns Research Group, ANZAC Research Institute, University of Sydney, Concord, NSW, 2139, Australia

    Roxanne Parungao & Yiwei Wang

  4. Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou, 450000, China

    Shuangshuang Zheng & Yi Nie

  5. Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Bei**g, 100190, China

    Yi Nie

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  1. Xueyan Hu
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Correspondence to Yi Nie, Tianqing Liu or Kedong Song.

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Hu, X., Xu, J., Li, W. et al. Therapeutic “Tool” in Reconstruction and Regeneration of Tissue Engineering for Osteochondral Repair. Appl Biochem Biotechnol 191, 785–809 (2020). https://doi.org/10.1007/s12010-019-03214-8

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