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Beware Pathological Findings of the Stomach in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis

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Abstract

Abnormal anatomic findings are a major concern before performing bariatric surgery, while pathological changes are considered less often. The present study aimed to investigate the incidences of gastric lesions warranting follow-up in patients undergoing bariatric surgery. Meta-analyses were conducted to calculate the pooled incidences of gastric lesions in patients undergoing bariatric surgery. Fifty-nine studies including 32,789 patients were included: 26 on endoscopic biopsy, 26 on pathological findings of the excised specimen, five on the intraoperative exploration results, and two on both preoperative endoscopy and postoperative specimen. Generally, atrophic gastritis (3.05% (95% CI (confidence interval) 1.53–6.09)), intestinal metaplasia (2.44% (95% CI 1.76–3.25)), and GIST (gastrointestinal stromal tumor) (0.45% (95% CI 0.31–0.60)) were not rarely found. Routine preoperative endoscopy was applied in 16 studies, and the pooled incidences of atrophic gastritis and intestinal metaplasia were 2.64% (95% CI 0.78–8.9) and 2.70% (95% CI 0.9–5.42), respectively. Hp. (Helicobacter pylori) screening and eradication were routinely performed in 10 studies, and that was related to a reduced incidence of atrophic gastritis (0.94% (95% CI 0.03–2.92)) vs. 4.31% (95% CI 2.01–9.23). GIST was more likely to be found by intraoperative exploration than by preoperative endoscopy (0.68% (95% CI 0.50–0.93) vs. 0.23% (95% CI 0.11–0.52)). Patients undergoing bariatric surgery demonstrated non-negligible incidences of gastric pathologies warranting follow-up. Preoperative endoscopy and careful intraoperative exploration should be routinely performed, and Hp. screening and eradication are suggested before endoscopy. In condition that such findings are detected, sleeve gastrectomy may be preferred over Roux-en-Y gastric bypass.

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Acknowledgments

The present systematic review was registered in PROSPERO (register number CRD42019131744), and the proposal is available at https://www.crd.york.ac.uk/PROSPERO.

Funding

This work was supported by the Fourth Military Medical University science and technology development fund (2019XC032) and Shaanxi provincial natural science fund subject (2015JQ8298).

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Author notes

  1. Shiqi Wang, Quan Wang and Lei Xu contributed equally to this work.

Authors and Affiliations

  1. Department of Gastrointestinal Surgery, ****g Hospital of Digestive Diseases, ****g Hospital, Fourth Military Medical University, Changlexi St. 127#, **’An City, Shaanxi Province, China

    Shiqi Wang, Pengfei Yu, Qin Li, **aohua Li, Man Guo, Bo Lian & Gang Ji

  2. Laboratory of Surgical Oncology, Peking University People’s Hospital, Peking University, Bei**g, China

    Quan Wang

  3. **’an Hospital of Traditional Chinese Medicine, **’An, China

    Lei Xu

  4. Department of Biomedical Engineering, School of Life Science and Technology, **’an Jiaotong University, **’an, China

    Lei Xu

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  1. Shiqi Wang
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Correspondence to Shiqi Wang or Gang Ji.

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Wang, S., Wang, Q., Xu, L. et al. Beware Pathological Findings of the Stomach in Patients Undergoing Bariatric Surgery: a Systematic Review and Meta-analysis. OBES SURG 31, 337–342 (2021). https://doi.org/10.1007/s11695-020-05029-7

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