Abstract
In this study, the Fe3O4 nanoparticles with particle size from 5 to 20 nm were synthesized using the thermal decomposition method. Magnetic hyperthermia measurements on these nanoparticles show moderate values of the specific absorption rates (SAR) in applied AC magnetic fields of amplitude 200 Oe and frequencies of 450 kHz. The highest value of SAR is 123.31 W/g for 20 nm Fe3O4 MNPs. The theoretical results within the framework of the linear response theory were used for comparing with experimental ones. The value of SAR obtained through magnetothermal measurements is found to be in excellent agreement with that obtained using the linear response theory. These results open the path to a more accurate prediction for synthesis of magnetic fluids for applications in magnetic hyperthermia.
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22 March 2021
A Correction to this paper has been published: https://doi.org/10.1007/s11051-021-05178-5
References
Abu-Aljarayesh, AI-Bayrakdar A, Mahmood SH (1993) The effect of heating on the magnetic properties of Fe304 fine particles. J Magnetismand Magn Mater 123:267–272. https://doi.org/10.1016/0304-8853(93)90452-8
Araújo-Neto RP, Silva-Freitas EL, Carvalho JF, Pontes TRF, Silva KL, Damasceno IHM, Egito EST, Dantas AL, Morales MA, Carriço AS (2014) Monodisperse sodium oleate coated magnetite high susceptibility nanoparticles for hyperthermia applications. J Magn Magn Mater 364:72–79. https://doi.org/10.1016/j.jmmm.2014.04.001
Behshid B, Ahmad K, Hojjat S-A, del Puerto MM, Morteza M (2012) Synthesis of high intrinsic loss power aqueous ferrofluids of iron oxide nanoparticles by citric acid-assisted hydrothermal-reduction route. J Solid State Chem 187:20–26. https://doi.org/10.1016/j.jssc.2011.12.011
Caetano PMA, Albuquerque AS, Fernandez-Outon LE, Macedo WAA, Ardisson JD (2018) Structure, magnetism and magnetic induction heating of NixCo(1-x)Fe2O4 nanoparticles. J Alloys Compd 758:247–255. https://doi.org/10.1016/j.jallcom.2018.05.124
Cao D, Li H, Pan L, Li J, Wang X, **g P, Cheng X, Wang W, Wang J, Liu Q (2016) High saturation magnetization of γ-Fe2O3 nano-particles by a facile one-step synthesis approach. Sci Rep 6:32360. https://doi.org/10.1038/srep32360
Carrey J, Mehdaoui B, Respaud M (2011) Simple models for dynamic hysteresis loops calculation: application to hyperthermia optimization. J Appl Phys 109:083921. https://doi.org/10.1063/1.3551582
Daou TJ, Pourroy G, Bégin-Colin S, Grenèche JM, Ulhaq-Bouillet C, Legaré P, Bernhardt P, Leuvrey C, Rogez G (2006) Hydrothermal synthesis of monodisperse magnetite nanoparticles. Chem Mater 18:4399–4404. https://doi.org/10.1021/cm060805r
Deatsch AE, Evans BA (2014) Heating efficiency in magnetic nano particle hyperthermia. J Manetism Magn Mater 354:163–172. https://doi.org/10.1016/j.jmmm.2013.11.006
Dieter W, Andreas M (1999) Thermal effect limits in ultrahigh-density magnetic recording. IEEE Trans Magn 35:4423–4439. https://doi.org/10.1109/20.809134
Dieter W, Andreas M, Liesl F, Best Margaret E, Lee W, Toney Mike F, Schwickert M, Thiele J-U, Doerner Mary F (2000) High K/sub u/materials approach to 100 Gbits/in/sup 2. IEEE Trans Magn 36:10–15. https://doi.org/10.1109/20.824418
Domingos RF, Baalousha MA, Yon J-N, Marcia RM, Nathalie T, Lead JR, Leppard GG, Wilkinson KJ (2009) Characterizing manufactured nanoparticles in the environment: multimethod determination of particle sizes. Environ Sci Technol 43:7277–7284. https://doi.org/10.1021/es900249m
Ebrahimisadr S, Aslibeiki B, Asadi R (2018) Magnetic hyperthermia properties of iron oxide nanoparticles: the effect of concentration. Physica C: Superconductivity and its Applications 549:119–121. https://doi.org/10.1016/j.physc.2018.02.014
Falk MH, Issels RD (2001) Hyperthermia in oncology. Int J Hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 17:1–18. https://doi.org/10.1080/02656730150201552
Faraji YYM, Rezae M (2010) Magnetic nanoparticles: synthesis, stabilization, functionalization, characterization and applications. J Iran Chem Soc 7:1–37. https://doi.org/10.1007/bf03245856
Faraji M, Yamini Y, Rezaee M (2010) Magnetic nanoparticles: synthesis, stabilization, functionalization, characterization, and applications. J Iran Chem Soc 7:1–37. https://doi.org/10.1007/bf03245856
Fortin JP, Wilhelm C, Servais J, Menager C, Bacri JC, Gazeau F (2007) Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J Am Chem Soc 129:2628–2635. https://doi.org/10.1021/ja067457e
Fuentes M, Mateo C, Rodriguez A, Casqueiro M, Tercero JC, Riese HH, Fernández-Lafuente R, Guisán JM (2006) Detecting minimal traces of DNA using DNA covalently attached to superparamagnetic nanoparticles and direct PCR-ELISA. Biosens Bioelectron 21:1574–1580. https://doi.org/10.1016/j.bios.2005.07.017
Fuentes-García JA, Diaz-Cano AI, Guillen-Cervantes A, Santoyo-Salazar J (2018) Magnetic domain interactions of Fe(3)O(4) nanoparticles embedded in a SiO(2) matrix. Sci Rep 8:5096. https://doi.org/10.1038/s41598-018-23460-w
Gangopadhyay S, Hadjipanayis GC, Dale B, Sorensen CM, Klabunde KJ, Papaefthymiou V, Kostikas A, Hu C (1992) Magnetic properties ofultrafine iron particles. Phys Rev B 45:9778–9787. https://doi.org/10.1103/physrevb.45.9778
Gilchrist RK, Medal R, Shorey WD, Hanselman RC, Parrott JC, Taylor CB (1957) Selective inductive heating of lymph nodes. Ann Surg 146:596–606. https://doi.org/10.1097/00000658-195710000-00007
Gneveckow U, Jordan A, Scholz R, Bruss V, Waldofner N, Ricke J, Feussner A, Hildebrandt B, Rau B, Wust P (2004) Description and characterization of the novel hyperthermia- and thermoablation-system MFH 300F for clinical magnetic fluid hyperthermia. Med Phys 31:1444–1451. https://doi.org/10.1118/1.1748629
Gonzales-Weimuller M, Zeisberge M, Krishnan KM (2009) Size-dependent heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia. J Magn Magn Mater 321:1947–1950. https://doi.org/10.1016/j.jmmm.2008.12.017
Goya GF, Berquo TS, Fonseca FC (2003) Static and dynamic magnetic properties of spherical magnetite nanoparticles. J Appl Phys 94:3520–3528. https://aip.scitation.org/doi/10.1063/1.1599959. Accessed 17 Aug 2020
Gyergyek S, Makovec D, Jagodič M, Drofenik M, Schenk K, Jordan O, Kovač J, Dražič G, Hofmann H (2017) Hydrothermal growth of iron oxide NPs with a uniform size distribution for magnetically induced hyperthermia: structural, colloidal and magnetic properties. J Alloys Compd 694:261–271. https://doi.org/10.1016/j.jallcom.2016.09.238
Ha PT, Le TTH, Bui TQ, Pham HN, Hod AS, Nguyen LT (2019) Doxorubicin release by magnetic inductive heating and in vivo hyperthermia-chemotherapy combined cancer treatment of multifunctional magnetic nanoparticles. New J Chem 43:5404–5413. https://doi.org/10.1039/C9NJ00111E
Habib AH, Ondeck CL, Chaudhary P, Bockstaller MR, McHenry ME (2008) Evaluation of Iron-cobalt/ferrite core-shell nanoparticles for cancer thermotherapy. J Appl Phys 103:07A307–301–307A307–303. https://doi.org/10.1063/1.2830975
Hao R, **ng R, Xu Z, Hou Y, Gao S, Sun S (2010) Synthesis, functionalization, and biomedical applications of multifunctional magnetic nanoparticles. Adv Mater 22:2729–2742. https://doi.org/10.1002/adma.201000260
Hariani PL, Faizal M, Ridwan M, Setiabudidaya AD (2013) Synthesis and properties of Fe3O4 nanoparticles by co-precipitation method to removal procion dye. Int J Environ Sci Dev 4:336–340. https://doi.org/10.7763/IJESD.2013.V4.366
Hironori L, Kosuke T, Takuya N, Tetsuya O (2007) Synthesis of Fe3O4 nanoparticles with various sizes and magnetic properties by controlled hydrolysis. J Colloid Interface Sci 314:274–280. https://doi.org/10.1016/j.jcis.2007.05.047
Janes R, Chubykalo-Fesenko O, Kachkachi H, Garanin DA, Evans R, Chantrell DW (2007) Effective anisotropies and energy barriers of magnetic nanoparticles with Néel surface anisotropy. Phys Rev B 76:064416–064411–064416-064413. https://doi.org/10.1103/PhysRevB.76.064416
Jie ZZ, Ying CX, Nian WB, Wu SC (2008) Hydrothermal synthesis and self-assembly of magnetite (Fe3O4) nanoparticles with the magnetic and electrochemical properties. J Cryst Growth 310:5453–5457. https://doi.org/10.1016/j.jcrysgro.2008.08.064
**g-Hong H, Parab HJ, Ru-Shi L, Tsung-Ching L, Michael H, Chung-Hsuan C, Hwo-Shuenn S, **-Ming C, Din-** T, Yeu-Kuang H (2008) Investigation of the growth mechanism of iron oxide nanoparticles via a seed-mediated method and its cytotoxicity studies. J Phys Chem C 112:15684–15690. https://doi.org/10.1021/jp803452j
Khandhar AP, Ferguson RM, Simon JA, Krishnan KM (2012) Tailored magnetic nanoparticles for optimizingmagnetic fluid hyperthermia. J Biomed Mater Res Part A 100A:728–737. https://doi.org/10.1002/jbm.a.34011
Khanna L, Verma NK, Tripathi SK (2018) Burgeoning tool of biomedical applications - superparamagnetic nanoparticles. J Alloys Compd 752:332–353. https://doi.org/10.1016/j.jallcom.2018.04.093
Krishnan KM (2010) Biomedical nanomagnetics: a spin through possibilities in imaging, diagnostics and therapy. IEEE Trans Magn 46:2523–2558. https://doi.org/10.1109/TMAG.2010.2046907
Kwon SG, Piao Y, Park J, Angappane S, Jo Y, Hwang N-M, Park J-G, Hyeon T (2007) Kinetics of monodisperse iron oxide nanocrystal formation by “heating-up” process. J Am Chem Soc 129:12571–12584. https://doi.org/10.1021/ja074633q
Le ThiThu Huong NH, HaiDoan D, Nhung HTM, ThucQuang B, HongNam P, QuocThong P, XuanPhuc N, PhuongThu H (2016) Folate attached, curcumin loaded Fe3O4 nanoparticles: a novel multifunctional drug delivery system for cancer treatment. Mater Chem Phys 172:98–104. https://doi.org/10.1016/j.matchemphys.2015.12.065
Le TTH, Ha TMT, Le MH, Pham HN, Ha PT (2018) Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy. J Mater Sci 53:13826–13842. https://doi.org/10.1007/s10853-018-2574-z
Liang J, Li L, Luo M, Junzhuo F, Hu Y (2010) Synthesis and properties of magnetite Fe3O4 via a simple hydrothermal route. Solid State Sci 12:1422–1425. https://doi.org/10.1016/j.solidstatesciences.2010.05.022
Lobato MBMNCC, de Mello Ferreira A (2017) Characterization and chemical stability of hydrophilic and hydrophobic magnetic nanoparticles. Mater Res 20(3):736–746. https://doi.org/10.1590/1980-5373-MR-2016-0707
Lu A-H, Salabas EL, Schuth F (2007) Magnetic nanoparticles: synthesis, protection, functionalization, and application. Angew Chem Int Ed 46:1222–1244. https://doi.org/10.1002/anie.200602866
Maenosono S, Saita S (2006) Theoretical assessment of FePt nanoparticles as heating elements for magnetic hyperthermia. IEEE Trans Magn 42:1638–1642. https://doi.org/10.1109/TMAG.2006.872198
Maity D, Choo S-G, Yi J, Ding J, Xue JM (2009) Synthesis of magnetite nanoparticles via a solvent-free thermal decomposition route. J Magn Magn Mater 321:1256–1259. https://doi.org/10.1016/j.jmmm.2008.11.013
Manish S, Jay S, Madhu Y, Kumar GD, Mishra RK, Tripathif S, Ojha AK (2012) Synthesis of superparamagnetic bare Fe3O4 nanostructures and core/shell (Fe3O4/alginate) nanocomposites. Carbohydr Polym 89:821–829. https://doi.org/10.1016/j.carbpol.2012.04.016
Mehdaoui B, Meffre A, Carrey J, Lachaize S, Lacroix L-M, Gougeon M, Chaudret B, Respaud M (2011) Optimal size of nanoparticles for magnetic hyperthermia: a combined theoretical and experimental study. Adv Funct Mater 21:4573–4581. https://doi.org/10.1002/adfm.201101243
Mousa Nazari NG, Maddah H, Motlagh MM (2014) Synthesis and characterization of maghemite nanopowders by chemical precipitation method. J Nanostruct Chem 99:1–5. https://doi.org/10.1007/s40097-014-0099-9
Ningombam GS, Ningthoujam RS, Kalkura SN, Singh NR (2018) Induction heating efficiency of water-dispersible Mn0.5Fe2.5O4@YVO4:Eu3+ magnetic-luminescent nanocomposites in an acceptable ac magnetic field: hemocompatibility and cytotoxicity studies. J Phys Chem B 122:6862–6871. https://doi.org/10.1021/acs.jpcb.8b02364
Oanh VTK, Lam TD, Thu VT, Lu LT, Nam PH, Tam LT, Manh DH, Phuc NX (2016) A novel route for preparing highly stable Fe3O4 fluid with poly(acrylic acid) as phase transfer ligand. J Electron Mater 45:4010–4017. https://doi.org/10.1007/s11664-016-4650-y
Obaidat BIIM, Haik Y (2015) Magnetic properties of magnetic nanoparticles for efficient hyperthermia. Nanomaterials 5:63–89. https://doi.org/10.3390/nano5010063
Phong LHNPT, Manh DH, Thanh TD, Van Khiem N, Le Van Hong, Phuc NX (2011) The effect of artificial boundary grain on the magneto- and electro-transport properties of (1−x)La0.7Ca0.3MnO3+xA (A=Al2O3 and Ag) nanocomposite. Adv Nat Sci Nanosci Nanotechnol 2:025003–025009. https://doi.org/10.1088/2043-6262/2/2/025003
Phong PT, Nguyen LH, Lee IJ, Phuc NX (2017) Computer simulations of contributions of Néel and Brown relaxation to specific loss power of magnetic fluids in hyperthermia. J Electron Mater 46:2393–2405. https://doi.org/10.1007/s11664-017-5302-6
Phong PT, Phuc NX, Nam PH, Chien NV, Dung DD, Linh PH (2018) Size-controlled heating ability of CoFe2O4 nanoparticles for hyperthermia applications. Phys B Condens Matter 531:30–34. https://doi.org/10.1016/j.physb.2017.12.010
Phuc NX, Tuan NA, Thuan NC, Tuan VA, Hong LV (2008) Magnetic nanoparticles as smart heating mediator for hyperthermia and sorbent regeneration. Adv Mater Res 55-57:27–32. https://doi.org/10.4028/www.scientific.net/AMR.55-57.27
Rafique MY, Pan LQ, Javed Q, Iqbal MZ, Qui HM, Farooq MH, Guo ZG, Tanveer M (2013) Growth of monodisperse nanospheres of MnFe2O4 with enhanced magnetic and optical properties. Chinese Physics B 22:107101–107101-107101-107107. https://doi.org/10.1088/1674-1056/22/10/107101
Rao KS, Nayakulu SR, Varma MC, Choudary G, Rao K (2018) Controlled phase evolution and the occurrence of single domain CoFe2O4 nanoparticles synthesized by PVA assisted sol-gel method. J Magn Magn Mater 451:602–608. https://doi.org/10.1016/j.jmmm.2017.11.069
Rosensweig RE (2002) Heating magnetic fluid with alternating magnetic field. J Magn Magn Mater 252:370–374. https://doi.org/10.1016/S0304-8853(02)00706-0
Serantes D, Baldomir D, Martinez-Boubeta C, Simeonidis K, Angelakeris M, Natividad E, Castro M, Mediano A, Chen D-X, Sanchez A, Balcells L, Martínez B (2010) Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles. J Appl Phys 108:073918–073911–073918-073915. https://doi.org/10.1063/1.3488881
Shideh A, Chin-Hua C, Sarani Z, Kasra S, Nilofar A (2012) Synthesis of Fe3O4 nanocrystals using hydrothermal approach. J Magn Magn Mater 324:4147–4150. https://doi.org/10.1016/j.jmmm.2012.07.023
Shouheng S, Hao Z, Robinson DB, Simone R, Rice PM, Wang SX, Guanxiong L (2004) Monodisperse MFe2O4 (M = Fe, Co, Mn) Nanoparticles. J Am Chem Soc 126:273–279. https://doi.org/10.1021/ja0380852
Sun G, Berezin MY, Fan J, Lee H, Ma J, Zhang K, Wooley KL, Achilefu S (2010) Bright fluorescent nanoparticles for develo** potential optical imaging contrast agents. Nanoscale 2:548–558. https://doi.org/10.1039/B9NR00304E
Trohidou KN (2005) Surface effects in magnetic nanoparticles. Springer, New York
Usov NA, Grebenshchikov YB (2009) Magnetic Nanoparticles. Wiley-VCH, Weinheim
Vuong TKO, Tran DL, Le TL, Pham DV, Pham HN, Le Ngo TH, Do HM, Nguyen XP (2015) Synthesis of high-magnetization and monodisperse Fe3O4 nanoparticles via thermal decomposition. Mater Chem Phys 163:537–544. https://doi.org/10.1016/j.matchemphys.2015.08.010
Wang J, **gjun S, Qian S, Qianwang C (2003) One-step hydrothermal process to prepare highly crystalline Fe3O4 nanoparticles with improved magnetic properties. Mater Res Bull 38:1113–1118. https://doi.org/10.1016/S0025-5408(03)00129-6
Xu Y-Y, Zhou M, Geng H-J, Hao J-J, Ou Q-Q, Qi S-D, Chen H-L, Chen X-G (2012) A simplified method for synthesis of Fe3O4@PAA nanoparticles and its application for the removal of basic dyes. Appl Surf Sci 258:3897–3902. https://doi.org/10.1016/j.apsusc.2011.12.054
Yugang S, Younan X (2004) Mechanistic study on the replacement reaction between silver nanostructures and chloroauric acid in aqueous medium. J Am Chem Soc 126:3892–3901. https://doi.org/10.1021/ja039734c
Zhao Y, Qiu Z, Huang J (2008) Preparation and analysis of Fe3O4 magnetic nanoparticles used as targeted-drug carriers* *Supported by the Technology Project of Jiangxi Provincial Education Department and Jiangxi Provincial Science Department. Chin J Chem Eng 16:451–455. https://doi.org/10.1016/S1004-9541(08)60104-4
Zhi** Z, Si-Shen F (2006) Nanoparticles of poly(lactide)/vitamin E TPGS copolymer for cancer chemotherapy: synthesis, formulation, characterization and in vitro drug release. Biomaterials 27:262–270. https://doi.org/10.1016/j.biomaterials.2005.05.104
Zhu N, Ji H, Yu P, Niu J, Farooq MU, Akram MW, Udego IO, Li H, Niu X (2018) Surface modification of magnetic iron oxide nanoparticles. Nanomaterials 8:1–27. https://doi.org/10.3390/nano8100810
Zinn S, Semiatin SL (1988) Elements of induction heating: design, control, and applications. ASM International, USA
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This research is funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 103.02-2017.339.
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Nguyen, L.H., Oanh, V.T.K., Nam, P.H. et al. Increase of magnetic hyperthermia efficiency due to optimal size of particles: theoretical and experimental results. J Nanopart Res 22, 258 (2020). https://doi.org/10.1007/s11051-020-04986-5
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DOI: https://doi.org/10.1007/s11051-020-04986-5