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Development and applications of deep eutectic solvents in different chromatographic techniques

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Abstract

Deep eutectic solvents (DESs) being inexpensive, easy to prepare, biocompatible, biodegradable and environmentally benign have aroused as the most propitious greener solvents for designing novel analytical methods of chemical analysis specially covering almost major fields of chromatography. This review article is majorly concerned with the analytical evaluation of DESs as new generation solvents for use as (a) modifier of silica gel surface via silylation reaction to create new stationary phases, (b) mobile phase (or developer) in liquid chromatography and (c) mobile phase additive to improve chromatographic performance. The sequential evolution of DESs has been briefly presented in tabular form since their beginning from the development of choline chloride/urea eutectic mixture in 2003. It has been observed that three more important properties (ionic conductivity, polarity and viscosity) of DESs can be adjusted to the desired level by proper selection of molar composition of hydrogen bond donor and hydrogen bond acceptor and water content. In this review, we present the recent applications of DESs in chromatography covering the period of the last two decades for assessing their suitability as a new class of green solvents.

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  1. Department of Electrical and Electronics Engineering, Mewat Engineering College, Gurugram University, Nuh, Haryana, India

    Mohammad Faraz Ahmer

  2. Physical Sciences Section, School of Sciences, Maulana Azad National Urdu University, Hyderabad, TS, 500032, India

    Qasim Ullah

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Ahmer, M.F., Ullah, Q. Development and applications of deep eutectic solvents in different chromatographic techniques. JPC-J Planar Chromat 35, 549–570 (2022). https://doi.org/10.1007/s00764-022-00216-x

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