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Sub-10-nm multicolored gold nanoparticles for colorimetric determination of antibiotics via formation of interlocking rings

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Abstract

A general approach is presented for synthesis of multicolored gold nanoparticles (GNPs) by Au(I)-mediated generation of interlocking rings in proteins and antibiotics. The Au(I) ions are shuttled from proteins to antibiotics, and this causes the formation of interlocking rings. The multicolored GNPs of different sizes were synthesized in the rings by using the rapid nucleation method. To take the unique colors of GNPs, a functional array was designed for the colorimetric determination and discrimination of antibiotics, specifically of amoxicillin, chlortetracycline, erythromycin, spiramycin, neomycin, thiamphenicol, gentamycin and lincomycin. The method is based on the “three color” (RGB) principle. The color response patterns are characteristic for each antibiotic and can be quantitatively differentiated by statistical techniques. The limits of detection (LOD, at S/N = 3) for spiramycin (Sp) have been calculated to be 0.18 μM and 0.10 μM in water and milk, respectively. The good linear range (from 0.3 to 3.5 μM) has been used for the quantitative assay of Sp in a certified reference material.

Schematic presentation of gold nanoparticles (GNPs) synthesis via formation of interlocking rings in protein and antibiotics. The Au(I) ions mediate protein and antibiotics to be interlocking rings, which are quickly fixed via microwave reaction. The GNPs are synthesized and assembled in the rings.

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Acknowledgments

This work is supported by the Natural Science Foundation of China (21607083), Technicians Troop Construction Projects of Henan Province (No. C20150029), Natural Science Foundation of Henan (162300410206), and Scientific and Technological Project of Henan Province (162102310484).

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Authors and Affiliations

  1. College of Physics and Electronic Engineering, Nanyang Normal University, Nanyang, 473061, China

    Yumin Leng, Yu Fu, Zhiwen Lu, Chenxi Du & Linfeng Ma

  2. College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, 473061, China

    Zhipei Sang & Kecheng Liu

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  1. Yumin Leng
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Correspondence to Yumin Leng.

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Leng, Y., Fu, Y., Lu, Z. et al. Sub-10-nm multicolored gold nanoparticles for colorimetric determination of antibiotics via formation of interlocking rings. Microchim Acta 186, 803 (2019). https://doi.org/10.1007/s00604-019-3949-9

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