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Overview: Lipid Metabolism in the Tumor Microenvironment

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Lipid Metabolism in Tumor Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1316))

Abstract

The tumor microenvironment represents the dynamic network consisting of tumor cells, stromal cells, and multiple lineages of immune subsets. It is well recognized that metabolic crosstalk within the tumor microenvironment (TME) greatly shapes both the composition and functionality of the infiltrated immune cells and therefore critically regulate the antitumor immunity. In general, most solid tumors are considered as lipid-enriched environment, which is beneficial for tumor cell growth and immune escape. Here we briefly summarize the effects of accumulated lipids on tumor cells and immune cells. We also discuss the possibility of targeting lipid metabolism within the TME and potential strategies for optimizing cancer treatment.

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Acknowledgments

The authors would like to thank members of Zhang Lab for helpful discussions. L.Z. is supported by Natural Science Foundation of China (NSFC 81971466) and Innovation Fund from the Chinese Academy of Medical Sciences (2016-I2M-1-005).

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Authors and Affiliations

  1. Suzhou Institute of Systems Medicine, Suzhou, Jiangsu, China

    Kaili Ma & Lianjun Zhang

  2. Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei**g, China

    Kaili Ma & Lianjun Zhang

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  1. Kaili Ma
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  2. Lianjun Zhang
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Correspondence to Lianjun Zhang .

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Editors and Affiliations

  1. Department of Medical Oncology, Chongqing University Cancer Hospital, Chongqing, China

    Yongsheng Li

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Ma, K., Zhang, L. (2021). Overview: Lipid Metabolism in the Tumor Microenvironment. In: Li, Y. (eds) Lipid Metabolism in Tumor Immunity. Advances in Experimental Medicine and Biology, vol 1316. Springer, Singapore. https://doi.org/10.1007/978-981-33-6785-2_3

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