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Functional Graphene Nanomaterials-Based Hybrid Scaffolds for Osteogenesis and Chondrogenesis

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Multifaceted Biomedical Applications of Graphene

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1351))

Abstract

With the emerging trends and recent advances in nanotechnology, it has become increasingly possible to overcome current hurdles for bone and cartilage regeneration. Among the wide type of nanomaterials, graphene (G) and its derivatives (graphene-based materials, GBMs) have been highlighted due to the specific physicochemical and biological properties. In this review, we present the recent development of GBM-based scaffolds for bone and cartilage engineering, focusing on the formulation/shape/size-dependent characteristics, types of scaffold and modification, biocompatibility, bioactivity and underlying mechanism, drawback and prospect of each study. From the findings described herein, mechanical property, biocompatibility, osteogenic and chondrogenic property of GBM-based scaffolds could be significantly enhanced through various scaffold fabrication methods and conjugation with polymers/nanomaterials/drugs. In conclusion, the results presented in this review support the promising prospect of using GBM-based scaffolds for improved bone and cartilage tissue engineering. Although GBM-based scaffolds have some limitations to be overcome by future research, we expect further developments to provide innovative results and improve their clinical potential for bone and cartilage regeneration.

Moon Sung Kang and Hee Jeong Jang equally contributed to this work.

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Acknowledgments

This research was supported by National Research Foundation of Korea (NRF) funded by the Ministry of Science (NRF-2021R1A2C2006013) and by Korea Evaluation Institute of Industrial Technology (KEIT) grant funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea) (No. 20014399).

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Authors and Affiliations

  1. Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, South Korea

    Moon Sung Kang, Hee Jeong Jang, Seok Hyun Lee, Suck Won Hong & Dong-Wook Han

  2. Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, USA

    Yong Cheol Shin

  3. Department of Food Science and Biotechnology, Gachon University, Seongnam, South Korea

    Jong Hun Lee

  4. Dental Life Science Research Institute/Innovation Research and Support Center for Dental Science, Seoul National University Dental Hospital, Seoul, South Korea

    Bongju Kim

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  1. Moon Sung Kang
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  8. Dong-Wook Han
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Correspondence to Dong-Wook Han .

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  1. Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, Korea (Republic of)

    Dong-Wook Han

  2. Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Busan, Korea (Republic of)

    Suck Won Hong

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Kang, M.S. et al. (2022). Functional Graphene Nanomaterials-Based Hybrid Scaffolds for Osteogenesis and Chondrogenesis. In: Han, DW., Hong, S.W. (eds) Multifaceted Biomedical Applications of Graphene. Advances in Experimental Medicine and Biology, vol 1351. Springer, Singapore. https://doi.org/10.1007/978-981-16-4923-3_4

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