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Bacterial Multidrug Tolerance and Persisters: Understanding the Mechanisms, Clinical Implications, and Treatment Strategies

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Antimicrobial Resistance

Abstract

Antibiotic resistance is a massive problem in today’s world and a serious threat to human civilization. Apart from being genetically resistant to antibiotics, the other important mechanism by which pathogenic bacteria can evade antibiotics is multidrug tolerance through the formation of persisters. In contrast to antibiotic-resistant bacteria, persister cells require no heritable genetic changes for surviving antibiotic treatment but become drug tolerant due to transient growth arrest. Since most antibiotics only target active metabolic pathways in the growing cells, non-growing persisters can escape the bactericidal effects of antibiotics and resume growth once the antibiotic is withdrawn resulting in treatment failure. Here in this book chapter, we try to highlight different aspects of persisters starting from unique characteristics of persisters, mechanisms of persister formation, clinical relevance, different techniques to study persisters, and some promising treatment options. Finally, we emphasize how focused research in this particular field can have a big impact to eradicate antimicrobial resistance.

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  1. Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India

    Mamta Singla, Vikas Chaudhary & Anirban Ghosh

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  2. Vikas Chaudhary
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  3. Anirban Ghosh
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  1. Department of Biotechnology, Savitribai Phule Pune University, Modern College of Arts, Science and Commerce, Ganeshkhind, Maharashtra, India

    Vinay Kumar

  2. Department of Botany, Savitribai Phule Pune University, Ramkrishna More Arts, Commerce and Science College, Pune, Maharashtra, India

    Varsha Shriram

  3. Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Rajasthan, India

    Atish Paul

  4. School of Biomedical Sciences, Mahatma Gandhi Mission Institute of Heal, Navi Mumbai, Maharashtra, India

    Mansee Thakur

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Mamta Singla, Chaudhary, V., Ghosh, A. (2022). Bacterial Multidrug Tolerance and Persisters: Understanding the Mechanisms, Clinical Implications, and Treatment Strategies. In: Kumar, V., Shriram, V., Paul, A., Thakur, M. (eds) Antimicrobial Resistance. Springer, Singapore. https://doi.org/10.1007/978-981-16-3120-7_2

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