Chirurgische Therapie von Lungenmetastasen

  • Living reference work entry
  • First Online:
Kompendium Internistische Onkologie

Zusammenfassung

Die pulmonale Metastasektomie ist im onkologischen Alltag etabliert. Die Indikation zu diesem Lokalverfahren wird individuell und interdisziplinär anhand von Prognosefaktoren gestellt. In Abhängigkeit der Tumorentität und der systemtherapeutischen Alternativen existieren variable Therapiekonzepte. Unabhängig vom Lebensalter ist sie mit geringer Morbidität, Mortalität und gutem Langzeitüberleben möglich. Zur vollständigen Metastasektomie gehören die Resektion aller Parenchymmetastasen und die systematische Lymphknotendissektion. Ziele sind ein längeres Überleben bis hin zur Kuration oder eine verdiente Systemtherapiepause für den Patienten. Durch die Kombination aus Resektion und Systemtherapie können Patienten langfristig profitieren. Zur Weiterentwicklung dieses Ansatzes bedarf es neuer Erkenntnisse in Tumorbiologie und Genetik von Primarius, Metastase und Rezidivmetastase. Der Fortschritt dieses onkologischen Therapiekonzepts wird hierdurch erreicht werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

Similar content being viewed by others

Literatur

  • Åberg T, Malmberg KA, Nilsson B, Nöu E (1980) The effect of metastasectomy: fact or fiction? Ann Thorac Surg 30(4):378–384

    Article  PubMed  Google Scholar 

  • Abrams HL, Spiro R, Goldstein. (1950) Metastaes in carcinoma: analysis of 1000 autopsied cases. Cancer 3:75–85

    Article  Google Scholar 

  • Adachi M, Mizuno M, Mitsui H, Kajiyama H, Suzuki S, Sekiya R, Utsumi F, Shibata K, Taniguchi T, Kawaguchi K, Yokoi K, Kikkawa F (2015) The prognostic impact of pulmonary metastasectomy in recurrent gynecologic cancers: a retrospective single-institution study. Nagoya J Med Sci 77(3):363–372

    PubMed  PubMed Central  Google Scholar 

  • Aka N, Iscan R, Köse G, Kaban I (2016) Benign pulmonary metastasizing leiomyoma of the uterus. J Clin Diagn Res 10(9):QD01–QD03. Epub 2016 Sep 1

    CAS  PubMed  PubMed Central  Google Scholar 

  • Alexander J, Haight C (1947) Pulmonary resection for solitary metastatic sarcomas and carcinomas. Surg Gynecol Obstet 85:129–146

    CAS  PubMed  Google Scholar 

  • Alt AL, Boorjian SA, Lohse CM, Costello BA, Leibovich BC, Blute ML (2011) Survival after complete surgical resection of multiple metastases from renal cell carcinoma. Cancer 117(13):2873–2882. https://doi.org/10.1002/cncr.25836. Epub 2011 Jan 10

    Article  PubMed  Google Scholar 

  • Amir E, Ooi WS, Simmons C, Kahn H, Christakis M, Popovic S, Kalina M, Chesney A, Singh G, Clemons M (2008) Discordance between receptor status in primary and metastatic breast cancer: an exploratory study of bone and bone marrow biopsies. Clin Oncol (R Coll Radiol) 20(10):763–768

    Article  CAS  Google Scholar 

  • Andrade RS, Kesler KA, Wilson JL, Brooks JA, Reichwage BD, Rieger KM, Einhorn LH, Brown JW (2004) Short- and long-term outcomes after large pulmonary resection for germ cell tumors after bleomycin-combination chemotherapy. Ann Thorac Surg 78(4):1224–1228. discussion 1228–9

    Article  PubMed  Google Scholar 

  • Anraku M, Yokoi K, Nakagawa K, Fujisawa T, Nakajima J, Akiyama H, Nishimura Y, Kobayashi K, Metastatic Lung Tumor Study Group of Japan (2004) Pulmonary metastases from uterine malignancies: results of surgical resection in 133 patients. J Thorac Cardiovasc Surg 127(4):1107–1112

    Article  PubMed  Google Scholar 

  • Bacci G, Rocca M, Salone M et al (2008) High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions. J Surg Oncol 98:415–420

    Article  PubMed  Google Scholar 

  • Barney JD, Chruchill EJ (1939) Adenocarcinoma of the kidney with metastasis to the lung: cured by nephrectomy and lobectomy. J Urol 42:269–276

    Article  Google Scholar 

  • Blackmon SH, Stephens EH, Correa AM, Hofstetter W, Kim MP, Mehran RJ et al (2012) Predictors of recurrent pulmonary metastases and survival after pulmonary metastasectomy for colorectal cancer. Ann Thorac Surg 94(6):1802–1809. https://doi.org/10.1016/j.athoracsur.2012.07.014

    Article  PubMed  Google Scholar 

  • Bölükbas S, Kudelin N, Eberlein M, Fisseler-Eckhoff A, Schirren J (2012) The influence of the primary tumor on the long-term results of pulmonary metastasectomy for metastatic renal cell carcinoma. Thorac Cardiovasc Surg 60(6):390–397

    PubMed  Google Scholar 

  • Bölükbas S, Sponholz S, Kudelin N et al (2014) Risk factors for lymph node metastases and prognosticators of survival in patients undergoing pulmonary metastasectomy for colorectal cancer. Ann Thorac Surg 97(6):1926–1932

    Article  PubMed  Google Scholar 

  • Branscheid D, Krysa S, Wollkopf G et al (1992) Does Nd-YAG laser extend the indication for resection of pulmonary metastases? Eur J Cardiothorac Surg 6:590–597

    Article  CAS  PubMed  Google Scholar 

  • Briccoli A, Rocca M, Salone M et al (2005) Resection of recurrent pulmonary metastases in patients with osteosarcoma. Cancer 104:1721–1725

    Article  PubMed  Google Scholar 

  • Briccoli A, Rocca M, Salone M et al (2010) High grade osteosarcoma of the extremities metastatic to the lung: long-term results in 323 patients treated combining surgery and chemotherapy, 1985–2005. Surg Oncol 19:193–199

    Article  PubMed  Google Scholar 

  • Bristow RE, Montz FJ, Lagasse LD, Leuchter RS, Karlan BY (1999) Survival impact of surgical cytoreduction in stage IV epithelial ovarian cancer. Gynecol Oncol 72(3):278–287

    Article  CAS  PubMed  Google Scholar 

  • Bross IDJ, Blumenson LE (1976) Metastatic sites that produce generalized cancer: identification and kinetics of generalizing sites. In: Weiss L (Hrsg) Fundamental aspects of metastasis. North-Holland Pub. Co., Amsterdam, S 359–375

    Google Scholar 

  • Burt BM, Ocejo S, Mery CM et al (2011) Repeated and aggressive pulmonary resections for leiomyosarcoma metastases extends survival. Ann Thorac Surg 92:1202–1207

    Article  PubMed  Google Scholar 

  • Cagini L, Nicholson AG, Horwich A, Goldstraw P, Pastorino U (1998) Thoracic metastasectomy for germ cell tumours: long term survival and prognostic factors. Ann Oncol 9(11):1185–1191

    Article  CAS  PubMed  Google Scholar 

  • Cahan WG, Castro EB (1975) Significance of a solitary lung shadow in patients with breast cancer. Ann Surg 181(2):137–143

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cahan WG, Castro EB, Hajdu SU (1974) The significance of a solitary lung shadow in patients with colon carcinoma. Cancer 33:414

    Article  CAS  PubMed  Google Scholar 

  • Canter RJ, Qin LX, Downey RJ et al (2007) Perioperative chemotherapy in patients undergoing pulmonary resection for metastatic soft-tissue sarcoma of the extremity: a retrospective analysis. Cancer 110:2050–2060

    Article  PubMed  Google Scholar 

  • Cerfolio RJ, Allen MS, Deschamps C, Daly RC, Wallrichs SL, Trastek VF, Pairolero PC (1994) Pulmonary resection of metastatic renal cell carcinoma. Ann Thorac Surg 57(2):339–344

    Article  CAS  PubMed  Google Scholar 

  • Chen F, Fu**aga T, Sato K, Sonobe M, Shoji T, Sakai H, Miyahara R, Bando T, Okubo K, Hirata T, Date H (2009a) Significance of tumor recurrence before pulmonary metastasis in pulmonary metastasectomy for soft tissue sarcoma. Eur J Surg Oncol 35(6):660–665

    Article  CAS  PubMed  Google Scholar 

  • Chen F, Miyahara R, Bando T, Okubo K, Watanabe K, Nakayama T, Toguchida J, Date H (2009b) Repeat resection of pulmonary metastasis is beneficial for patients with osteosarcoma of the extremities. Interact Cardiovasc Thorac Surg 9(4):649–653

    Article  PubMed  Google Scholar 

  • Choong PF, Pritchard DJ, Rock MG et al (1995) Survival after pulmonary metastasectomy in soft tissue sarcoma. Prognostic factors in 214 patients. Acta Orthop Scand 66:561–568

    Article  CAS  PubMed  Google Scholar 

  • Chua TC, Scolyer RA, Kennedy CW, Yan TD, McCaughan BC, Thompson JF (2012) Surgical management of melanoma lung metastases: an analysis of survival outcomes in 292 consecutive patients. Ann Surg Oncol 19(6):1774–1781

    Article  PubMed  Google Scholar 

  • Chudgar NP, Brennan MF, Tan KS, Munhoz RR, D’Angelo SP, Bains MS, Huang J, Park BJ, Adusumilli PS, Tap WD, Jones DR (2017) Is repeat pulmonary metastasectomy indicated for soft tissue sarcoma? Ann Thorac Surg 104(6):1837–1845. https://doi.org/10.1016/j.athoracsur.2017.07.024. Epub 2017 Nov 2

    Article  PubMed  PubMed Central  Google Scholar 

  • Clavero JM, Deschamps C, Cassivi SD, Allen MS, Nichols FC 3rd, Barrette BA, Larson DR, Pairolero PC (2006) Gynecologic cancers: factors affecting survival after pulmonary metastasectomy. Ann Thorac Surg 81(6):2004–2007

    Article  PubMed  Google Scholar 

  • Dabestani S, Marconi L, Hofmann F, Stewart F, Lam TB, Canfield SE, Staehler M, Powles T, Ljungberg B, Bex A (2014) Local treatments for metastases of renal cell carcinoma: a systematic review. Lancet Oncol 15(12):e549–e561. https://doi.org/10.1016/S1470-2045(14)70235-9. Epub 2014 Oct 26. Review

    Article  PubMed  Google Scholar 

  • Diemel KD, Klippe HJ, Branscheid D (2009) Pulmonary metastasectomy for osteosarcoma: is it justified? Recent Results Cancer Res 179:183–208

    Article  PubMed  Google Scholar 

  • Divis G (1927) Ein Beitrag zur operativen Behandlung der Lungengeschwülste. Acta Chir Scand 62:329–341

    Google Scholar 

  • Dominguez-Ventura A, Nichols FC 3rd. (2006) Lymphadenectomy in metastasectomy. Thorac Surg Clin 16(2):139–143

    Article  PubMed  Google Scholar 

  • Downey RJ, Rusch V, Hsu FI et al (2000) Chest wall resection for locally recurrent breast cancer: is it worthwhile? J Thorac Cardiovasc Surg 119(3):420–428

    Article  CAS  PubMed  Google Scholar 

  • Eckardt J, Licht PB (2012) Thoracoscopic versus open pulmonary metastasectomy: a prospective, sequentially controlled study. Chest 142(6):1598–1602. https://doi.org/10.1378/chest.12-0249

    Article  PubMed  Google Scholar 

  • Eder M (1984) Die Metastasierung: Fakten und Probleme aus immunpathologischer Sicht. Verh Dtsch Ges Pathol 68:1–11, Fischer, Stuttgart

    Google Scholar 

  • Fadel E, Court B, Chapelier AR, Droz JP, Dartevelle P (2000) One-stage approach for retroperitoneal and mediastinal metastatic testicular tumor resection. Ann Thorac Surg 69(6):1717–1721

    Article  CAS  PubMed  Google Scholar 

  • Fan J, Chen D, Du H et al (2015) Prognostic factors for resection of isolated pulmomnary metastases in breast cancer: a systematic review and meta-analyses. J Thorac Dis 7(8):1441–1451

    PubMed  PubMed Central  Google Scholar 

  • Faneyte IF, Rutgers EJ, Zoetmulder FA (1997) Chest wall resection in the treatment of locally recurrent breast carcinoma: indications and outcome for 44 patients. Cancer 80(5):886–891

    Article  CAS  PubMed  Google Scholar 

  • Ferguson PC, Deheshi BM, Chung P et al (2011) Soft tissue sarcoma presenting with metastatic disease: outcome with primary surgical resection. Cancer 117:372–379

    Article  PubMed  Google Scholar 

  • Fidler IJ, Hart JR (1981) The origin of metastastic heterogenity in tumors. Eur J Cancer 17:487–494

    Article  CAS  Google Scholar 

  • Fizazi K, Tjulandin S, Salvioni R et al (2001) Viable malignant cells after primary chemotherapy for disseminated nonseminomatous germ cell tumors: prognostic factors and role of postsurgery chemotherapy – results from an international study group. J Clin Oncol 19(10):2647–2657

    Article  CAS  PubMed  Google Scholar 

  • Fourquier P, Regnard JF, Rea S, Levi JF, Levasseur P (1997) Lung metastases of renal cell carcinoma: results of surgical resection. Eur J Cardiothorac Surg 11(1):17–21

    Article  CAS  PubMed  Google Scholar 

  • Friedel G, Hürtgen M, Penzenstadler M, Kyriss T, Toomes H (1999) Resection of pulmonary metastases from renal cell carcinoma. Anticancer Res 19(2C):1593–1596

    CAS  PubMed  Google Scholar 

  • Friedel G, Pastorino U, Ginsberg RJ, Goldstraw P, Johnston M, Pass H, Putnam JB, Toomes H, International Registry of Lung Metastases, London, England (2002) Results of lung metastasectomy from breast cancer: prognostic criteria on the basis of 467 cases of the International Registry of Lung Metastases. Eur J Cardiothorac Surg 22(3):335–344

    Article  PubMed  Google Scholar 

  • Gadd MA, Casper ES, Woodruff JM et al (1993) Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma. Ann Surg 218:705–712

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garavaglia E, Pella F, Montoli S, Voci C, Taccagni G, Mangili G (2010) Treatment of recurrent or metastatic low-grade endometrial stromal sarcoma: three case reports. Int J Gynecol Cancer 20(7):1197–1200

    Article  PubMed  Google Scholar 

  • Gelderblom H, **ks RC, Sydes M et al (2011) Survival after recurrent osteosarcoma: data from 3 European Osteosarcoma Intergroup (EOI) randomized controlled trials. Eur J Cancer 47:895–902

    Article  PubMed  Google Scholar 

  • Gilbert H, Kagan AR (1976) Metastases: incidence, detection and evaluation without histological confirmation. In: Weiss L (Hrsg) Fundamental aspects of metastasis. North-Holland Pub. Co., Amsterdam, S 315–405

    Google Scholar 

  • González Casaurrán G, Simón Adiego C, Peñalver Pascual R, Moreno Mata N, Lozano Barriuso MA, González Aragoneses F (2011) Surgery of female genital tract tumour lung metastases. Arch Bronconeumol 47:134–137

    Article  PubMed  Google Scholar 

  • Gonzalez M et al (2013) Risk factors for survival after lung metastasectomy in colorectal cancer patients: a systematic review and meta-analysis. Ann Surg Oncol 20(2):572–579. https://doi.org/10.1245/s10434-012-2726-3. Epub 2012 Oct 28

    Article  PubMed  Google Scholar 

  • Guerrera F et al (2017) Low accuracy of computed tomography and positron emission tomography to detect lung and lymph node metastases of colorectal cancer. Ann Thorac Surg 104(4):1194–1199

    Article  PubMed  Google Scholar 

  • Hamaji M, Cassivi SD, Shen KR et al (2012) Is lymph node dissection required in pulmonary metastasectomy for colorectal adenocarcinoma? Ann Thorac Surg 94(6):1796–1800

    Article  PubMed  Google Scholar 

  • Hamaji M, Chen F, Miyamoto E, Kondo T, Ohata K, Motoyama H, Hijiya K, Menju T, Aoyama A, Sato T, Sonobe M, Date H (2016) Surgical and non-surgical management of repeat pulmonary metastasis from sarcoma following first pulmonary metastasectomy. Surg Today 46(11):1296–1300

    Article  PubMed  Google Scholar 

  • Harpole DH Jr, Johnson CM, Wolfe WG, George SL, Seigler HF (1992) Analysis of 945 cases of pulmonary metastatic melanoma. J Thorac Cardiovasc Surg 103(4):743–748

    Article  PubMed  Google Scholar 

  • Harting MT, Blakely ML, Jaffe N et al (2006) Long-term survival after aggressive resection of pulmonary metastases among children and adolescents with osteosarcoma. J Pediatr Surg 41:194–199

    Article  PubMed  Google Scholar 

  • Headrick JR, Miller DL, Nagorney DM et al (2001) Surgical treatment of hepatic and pulmonary metastases from colon cancer. Ann Thorac Surg 71:975–980

    Article  CAS  PubMed  Google Scholar 

  • Hinton S, Catalano PJ, Einhorn LH, Nichols CR, David Crawford E, Vogelzang N, Trump D, Loehrer PJ Sr (2003) Cisplatin, etoposide and either bleomycin or ifosfamide in the treatment of disseminated germ cell tumors: final analysis of an intergroup trial. Cancer 97(8):1869–1875

    Article  CAS  PubMed  Google Scholar 

  • Hofmann HS, Neef H, Krohe K, Andreev P, Silber RE (2005) Prognostic factors and survival after pulmonary resection of metastatic renal cell carcinoma. Eur Urol 48(1):77–81; discussion 81–2

    Article  PubMed  Google Scholar 

  • Huang YM, Hou CH, Hou SM, Yang RS (2009) The metastasectomy and timing of pulmonary metastases on the outcome of osteosarcoma patients. Clin Med Oncol 3:99–105

    PubMed  PubMed Central  Google Scholar 

  • Inoue M, Ohta M, Iuchi K et al (2004) Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma. Ann Thorac Surg 78:238–244

    Article  PubMed  Google Scholar 

  • Internullo E, Cassivi SD, Van Raemdonck D, Friedel G, Treasure T, ESTS Pulmonary Metastasectomy Working Group (2008) Pulmonary metastasectomy: a survey of current practice amongst members of the European Society of Thoracic Surgeons. J Thorac Oncol 3(11):1257–1266

    Article  PubMed  Google Scholar 

  • Jamieson A, Sykes P, Eva L, Bergzoll C, Simcock B (2017) Subtypes of stage IV ovarian cancer; response to treatment and patterns of disease recurrence. Gynecol Oncol 146(2):273–278

    Article  PubMed  Google Scholar 

  • Johnston R (1983) Median sternotomy for resection of pulmonary metastases. J Thorac Cardiovasc Surg 85:516–522

    Article  CAS  PubMed  Google Scholar 

  • Kager L, Zoubek A, Potschger U et al (2003) Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols. J Clin Oncol 21:2011–2018

    Article  PubMed  Google Scholar 

  • Kane JM, Finley JW, Driscoll D et al (2002) The treatment and outcome of patients with soft tissue sarcomas and synchronous metastases. Sarcoma 6:69–73

    Article  PubMed  PubMed Central  Google Scholar 

  • Kanzaki R, Higashiyama M, Fujiwara A, Tokunaga T, Maeda J, Okami J, Nishimura K, Kodama K (2011a) Long-term results of surgical resection for pulmonary metastasis from renal cell carcinoma: a 25-year single-institution experience. Eur J Cardiothorac Surg 39(2):167–172

    Article  PubMed  Google Scholar 

  • Kanzaki R, Higashiyama M, Oda K, Fujiwara A, Tokunaga T, Maeda J et al (2011b) Outcome of surgical resection for recurrent pulmonary metastasis from colorectal carcinoma. Am J Surg 202(4):419–426

    Article  PubMed  Google Scholar 

  • Karim S, Nanji S, Brennan K, Pramesh CS, Booth CM (2017) Chemotherapy for resected colorectal cancer pulmonary metastases: utilization and outcomes in routine clinical practice. Eur J Surg Oncol 43(8):1481–1487

    Article  CAS  PubMed  Google Scholar 

  • Kelly CR, Langston HP (1956) The treatment of metastatic pulmonary malignancy. J Thorac Surg 316:298–315

    Article  Google Scholar 

  • Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K (2010) Metastatic behavior of breast cancer subtypes. J Clin Oncol 28(20):3271–3277

    Article  PubMed  Google Scholar 

  • Kesler KA, Kruter LE, Perkins SM, Rieger KM, Sullivan KJ, Runyan ML, Brown JW, Einhorn LH (2011) Survival after resection for metastatic testicular nonseminomatous germ cell cancer to the lung or mediastinum. Ann Thorac Surg 91(4):1085–1093.; discussion 1093. https://doi.org/10.1016/j.athoracsur.2010.12.034

    Article  PubMed  Google Scholar 

  • Ki EY, Lee KH, Park JS, Hur SY (2016) A clinicopathological review of pulmonary metastasis from uterine cervical cancer. Cancer Res Treat 48:266–272

    Article  CAS  PubMed  Google Scholar 

  • Kim HK, Cho JH, Lee HY et al (2014) Pulmonary metastasectomy for colorectal cancer: how many nodules, how many times? World J Gastroenterol 20(20):6133–6145

    Article  PubMed  PubMed Central  Google Scholar 

  • King JJ, Fayssoux RS, Lackman RD, Ogilvie CM (2009) Early outcomes of soft tissue sarcomas presenting with metastases and treated with chemotherapy. Am J Clin Oncol 32:308–313

    Article  PubMed  Google Scholar 

  • Kobayashi K, Kawamura M, Ishihara T (1999) Surgical treatment for both pulmonary and hepatic metastases from colorectal cancer. J Thorac Cardiovasc Surg 118(6):1090–1096

    Article  CAS  PubMed  Google Scholar 

  • Koong HN, Pastorino U, Ginsberg RJ (1998) Is there a role for pneumonectomy in pulmonary metastases? International registry of lung metastases. Ann Thorac Surg 68(6):2039–2043

    Article  Google Scholar 

  • Krönlein E (1884) Über Lungenchirurgie. Berl. Klin Wochenschr 9:129–136

    Google Scholar 

  • Kudelin N, Bölükbas S, Eberlein M, Schirren J (2013) Metastasectomy with standardized lymph node dissection for metastatic renal cell carcinoma: an 11-year single-center experience. Ann Thorac Surg 96(1):265–270. discussion 270–1

    Article  PubMed  Google Scholar 

  • Labianca R, Beretta GD, Kildani B et al (2010) Colon cancer. Crit Rev Oncol Hematol 74(2):106–133

    Article  PubMed  Google Scholar 

  • Landes U, Robert J, Perneger T et al (2010) Predicting survival after pulmonary metastasectomy for colorectal cancer: previous liver metastases matter. BMC Surg 3(10):17

    Article  Google Scholar 

  • Landreneau RJ et al (1991) Thorascopy neodymium: yttrium-aluminum garnet laser-assisted pulmonary resection. Ann Thorac Surg 52:1176

    Article  CAS  PubMed  Google Scholar 

  • Lanza LA, Natarajan G, Roth JA, Putnam JB Jr (1992) Long-term survival after resection of pulmonary metastases from carcinoma of the breast. Ann Thorac Surg 54(2):244–247. discussion 248

    Article  CAS  PubMed  Google Scholar 

  • Lee WS, Yun HR, Yun SH et al (2008) Treatment outcomes of hepatic and pulmonary metastases from colorectal carcinoma. J Gastroenterol Hepatol 23(8 Pt 2):e367–e372

    Article  PubMed  Google Scholar 

  • Leo F, Cagini L, Rocmans P, Cappello M, Geel AN, Maggi G, Goldstraw P, Pastorino U (2000) Lung metastases from melanoma: when is surgical treatment warranted? Br J Cancer 83(5):569–572

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Letourneau PA, **ao L, Harting MT et al (2011) Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. J Pediatr Surg 46:1333–1337

    Article  PubMed  PubMed Central  Google Scholar 

  • Limmer S, Oevermann E, Killaitis C et al (2010) Sequential surgical resection of hepatic and pulmonary metastases from colorectal cancer. Langenbecks Arch Surg 395(8):1129–1138

    Article  PubMed  PubMed Central  Google Scholar 

  • Liu D, Abolhoda A, Burt ME, Martini N, Bains MS, Downey RJ, Rusch VW, Bosl GJ, Ginsberg RJ (1998) Pulmonary metastasectomy for testicular germ cell tumors: a 28-year experience. Ann Thorac Surg 66(5):1709–1714

    Article  CAS  PubMed  Google Scholar 

  • Ludwig C, Stoelben E, Hasse J (2003) Disease-free survival after resection of lung metastases in patients with breast cancer. Eur J Surg Oncol 29(6):532–535

    Article  CAS  PubMed  Google Scholar 

  • Macherey S, Schlaak M, Doerr F, Grönke S, Heldwein M, Quaas A, Zander T, Hekmat K (2015) Chirurgische Therapie pulmonaler Metastasen des malignen Melanoms [Surgical therapy for pulmonary metastases from malignant melanoma]. Hautarzt 66(1):65–73. https://doi.org/10.1007/s00105-014-3555-z. PMID: 25576143

  • Margaritora S, Porziella V, D‘Andrilli A et al (2002) Pulmonary metastases: can accurate radiological evaluation avoid thoracotomic approach? Eur J Cardiothorac Surg 21(6):1111–1114

    Article  PubMed  Google Scholar 

  • McAfee MK, Allen MS, Trastek VF, Ilstrup DM, Deschamps C, Pairolero PC (1992) Colorectal lung metastases: results of surgical excision. Ann Thorac Surg 53(5):780–785; discussion 785–6

    Article  CAS  PubMed  Google Scholar 

  • McCormack PM, Martini N (1979) The changing role of surgery for pulmonary metastases. Ann Thorac Surg 28(2):139–145

    Article  CAS  PubMed  Google Scholar 

  • McCormack PM, Bains MS, Begg CB, Burt ME, Downey RJ, Panicek DM, Rusch VW, Zakowski M, Ginsberg RJ (1996) Role of video-assisted thoracic surgery in the treatment of pulmonary metastases: results of a prospective trial. Ann Thorac Surg 62(1):213–6; discussion 216-7. https://doi.org/10.1016/0003-4975(96)00253-6. PMID: 8678645

  • McDonald ML, Deschamps C, Ilstrup DM, Allen MS, Trastek VF, Pairolero PC (1994) Pulmonary resection for metastatic breast cancer. Ann Thorac Surg 58(6):1599–1602

    Article  CAS  PubMed  Google Scholar 

  • Meimarakis G, Angele M, Staehler M, Clevert DA, Crispin A, Rüttinger D, Löhe F, Preissler G, Hatz RA, Winter H (2011) Evaluation of a new prognostic score (Munich score) to predict long-term survival after resection of pulmonary renal cell carcinoma metastases. Am J Surg 202(2):158–167

    Article  PubMed  Google Scholar 

  • Meimarakis G, Rüttinger D, Stemmler J, Crispin A, Weidenhagen R, Angele M, Fertmann J, Hatz RA, Winter H (2013) Prolonged overall survival after pulmonary metastasectomy in patients with breast cancer. Ann Thorac Surg 95(4):1170–1180

    Article  PubMed  Google Scholar 

  • Meimarakis G, Spelsberg F, Angele M et al (2014) Resection of pulmonary metastases from colon and rectal cancer: factors to predict survival differ regarding to the origin of the primary tumor. Ann Surg Oncol 21(8):2563–2572. https://doi.org/10.1245/s10434-014-3646-1. Epub 2014 Mar 26

    Article  CAS  PubMed  Google Scholar 

  • Melloni G, Doglioni C, Bandiera A, Carretta A, Ciriaco P, Arrigoni G, Zannini P (2006) Prognostic factors and analysis of microsatellite instability in resected pulmonary metastases from colorectal carcinoma. Ann Thorac Surg 81(6):2008–2013

    Article  PubMed  Google Scholar 

  • Mercier F, Bakrin N, Bartlett DL, Goere D, Quenet F, Dumont F, Heyd B, Abboud K, Marolho C, Villeneuve L, Glehen O, PSOGI Working Group, BIG-RENAPE Working Group (2018) Peritoneal Carcinomatosis of rare ovarian origin treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a multi-institutional cohort from PSOGI and BIG-RENAPE. Ann Surg Oncol. https://doi.org/10.1245/s10434-018-6464-z. [Epub ahead of print]

  • Merkle NM, Meyer G, Bülzebruck H (1987) Operative Behandlung von Lungenmetastasen. In: Schildberg (Hrsg) Chirurgische Behandlung von Tumormetastasen. Bibliomed, Melsungen, S 191–206

    Google Scholar 

  • Miller G, Biernacki P, Kemeny NE et al (2007) Outcomes after resection of synchronous or metachronous hepatic and pulmonary colorectal metastases. J Am Coll Surg 205(2):231–238

    Article  PubMed  Google Scholar 

  • Miller J, Shoni M, Siegert C, Lebenthal A, Godleski J, McNamee C (2016) Benign metastasizing leiomyomas to the lungs: an institutional case series and a review of the recent literature. Ann Thorac Surg 101(1):253–258

    Article  PubMed  Google Scholar 

  • Moorcraft SY, Ladas G, Bowcock A, Chau I (2016) Management of resectable colorectal lung metastases. Clin Exp Metastasis 33(3):285–296

    Article  CAS  PubMed  Google Scholar 

  • Motzer RJ, Bander NH, Nanus DM (1996) Renal-cell carcinoma. N Engl J Med 335(12):865–875

    Article  CAS  PubMed  Google Scholar 

  • Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, Chen I, Bycott PW, Baum CM, Figlin RA (2007) Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med 356(2):115–124

    Article  CAS  PubMed  Google Scholar 

  • Müller KM, Respondek M (1990) Pulmonary metastasis: pathological anatomy. Lung 168(Suppl):1137–1144

    Article  PubMed  Google Scholar 

  • Murthy SC, Kim K, Rice TW, Rajeswaran J, Bukowski R, DeCamp MM, Blackstone EH (2005) Can we predict long-term survival after pulmonary metastasectomy for renal cell carcinoma? Ann Thorac Surg 79(3):996–1003

    Article  PubMed  Google Scholar 

  • Nanji S, Karim S, Tang E et al (2018) Pulmonary metastasectomy for colorectal cancer: predictors of survival in routine surgical practice. Ann Thorac Surg, pii: S0003-4975(18)30275-3. https://doi.org/10.1016/j.athoracsur.2018.02.007

  • Neumann HB, Patel A, Hanlon C, Wolchok JD, Houghton AN, Coit DG (2007) Stage-IV melanoma and pulmonary metastases: factors predictive of survival. Ann Surg Oncol 14(10):2847–2853

    Article  Google Scholar 

  • Oddsson SJ, Hardarson S, Petursdottir V, Jonsson E, Sigurdsson MI, Einarsson GV, Pfannschmidt J, Gudbjartsson T (2012) Synchronous pulmonary metastases from renal cell carcinoma – a whole nation study on prevalence and potential resectability. Scand J Surg 101(3):160–165

    Article  CAS  PubMed  Google Scholar 

  • Ogata Y, Matono K, Hayashi A, Takamor S, Miwa K, Sasatomi T et al (2005) Repeat pulmonary resection for isolated recurrent lung metastases yields results comparable to those after first pulmonary resection in colorectal cancer. World J Surg 29(3):363–368

    Article  PubMed  Google Scholar 

  • Oliaro A, Filosso PL, Bruna MC, Mossetti C, Ruffini E (2010) Pulmonary metastasectomy for melanoma. J Thorac Oncol 5(6 Suppl 2):187–191

    Google Scholar 

  • Onaitis MW, Petersen RP, Haney JC, Saltz L, Park B, Flores R et al (2009) Prognostic factors for recurrence after pulmonary resection of colorectal cancer metastases. Ann Thorac Surg 87(6):1684–1688

    Article  PubMed  Google Scholar 

  • Pameijer CR, Smith D, McCahill LE et al (2005) Full-thickness chest wall resection for recurrent breast carcinoma: an institutional review and meta-analysis. Am Surg 71(9):711–715

    Article  PubMed  Google Scholar 

  • Park JS, Kim HK, Choi YS, Kim K, Shim YM, Jo J, Lee WY, Chun HK, Park YS, Kang WK, Kim J (2010) Outcomes after repeated resection for recurrent pulmonary metastases from colorectal cancer. Ann Oncol 21(6):1285–1289

    Article  CAS  PubMed  Google Scholar 

  • Passot G, Kim BJ, Glehen O, Mehran RJ, Kopetz SE, Goere D, Overman MJ, Pocard M, Marchal F, Conrad C, Aloia TA, Vauthey JN, Chun YS, BIG-RENAPE Working Group (2018) Impact of RAS mutations in metastatic colorectal cancer after potentially curative resection: does site of metastases matter? Ann Surg Oncol 25(1):179–187

    Article  PubMed  Google Scholar 

  • Pastorino U, Buyse M, Friedel G et al (1997) Long-term results of lung metastasectomy: prognostic analyses based on 5206 cases – the international registry of lung metastases. J Thorac Cardiovasc Surg 113:37–49

    Article  CAS  PubMed  Google Scholar 

  • Petersen RP, Hanish SI, Haney JC, Miller CC 3rd, Burfeind WR Jr, Tyler DS, Seigler HF, Wolfe W, D’Amico TA, Harpole DH Jr (2007) Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma. J Thorac Cardiovasc Surg 133(1):104–110

    Article  PubMed  Google Scholar 

  • Pfannschmidt J, Hoffmann H, Muley T, Krysa S, Trainer C, Dienemann H (2002) Prognostic factors for survival after pulmonary resection of metastatic renal cell carcinoma. Ann Thorac Surg 74(5):1653–1657

    Article  PubMed  Google Scholar 

  • Pfannschmidt J, Muley T, Hoffmann H et al (2003) Prognostic factors and survival after complete resection of pulmonary metastases from colorectal carcinoma: experiences in 167 patients. J Thorac Cardiovasc Surg 126:732–739

    Article  PubMed  Google Scholar 

  • Pfannschmidt J, Klode J, Muley T et al (2006) Pulmonary metastasectomy in patients with soft tissue sarcomas: experiences in 50 patients. Thorac Cardiovasc Surg 54:489–492

    Article  CAS  PubMed  Google Scholar 

  • Pfannschmidt J, Hoffmann H, Dienemann H (2010a) Reported outcome factors for pulmonary resection in metastatic colorectal cancer. J Thorac Oncol 5(6 Suppl 2):S172–S178

    Article  PubMed  Google Scholar 

  • Pfannschmidt J, Hoffmann H, Dienemann H (2010b) Thoracic metastasectomy for nonseminomatous germ cell tumors. J Thorac Oncol 5(6 Suppl 2):S182–S186

    Article  PubMed  Google Scholar 

  • Pfannschmidt J, Egerer G, Bischof M et al (2012) Surgical intervention for pulmonary metastases. Dtsch Arztebl Int 109:645–651

    PubMed  Google Scholar 

  • Planchard D, Soria JC, Michiels S, Grunenwald D, Validire P, Caliandro R, Girard P, Le Chevalier T (2004) Uncertain benefit from surgery in patients with lung metastases from breast carcinoma. Cancer 100(1):28–35

    Article  PubMed  Google Scholar 

  • Pogrebniak HW, Roth JA, Steinberg SM et al (1991) Reoperative pulmonary resection in patients with metastatic soft tissue sarcoma. Ann Thorac Surg 52:197–203

    Article  CAS  PubMed  Google Scholar 

  • Pogrebniak HW, Haas G, Linehan WM, Rosenberg SA, Pass HI (1992) Renal cell carcinoma: resection of solitary and multiple metastases. Ann Thorac Surg 54(1):33–38

    Article  CAS  PubMed  Google Scholar 

  • Pol CC van der, van Geel AN, Menke-Pluymers MB et al (2009) Prognostic factors in 77 curative chest wall resections for isolated breast cancer recurrence. Ann Surg Oncol 16(12):3414–3421. https://doi.org/10.1245/s10434-009-0662-7

  • Predina JD, Puc MM, Bergey MR et al (2011) Improved survival after pulmonary metastasectomy for soft tissue sarcoma. J Thorac Oncol 6:913–919

    Article  PubMed  Google Scholar 

  • Reinke RT, Higgins CB, Niwayama G, Harris RH, Friedman PJ (1976) Bilateral pulmonary hilar lymphadenopathy. An unusual manifestation of metastatic renal cell carcinoma. Radiology 121(1):49–53

    Article  CAS  PubMed  Google Scholar 

  • Remy-Jardin M, Remy J, Giraud F, Marquette CH (1993) Pulmonary nodules: detection with thick-section spiral CT versus conventional CT. Radiology 187:513

    Article  CAS  PubMed  Google Scholar 

  • Renaud S, Falcoz PE, Olland A, Massard G (2013) Should mediastinal lymphadenectomy be performed during lung metastasectomy of renal cell carcinoma? Interact Cardiovasc Thorac Surg 16(4):525–528

    Article  PubMed  PubMed Central  Google Scholar 

  • Renaud S et al (2014a) Does nodal status influence survival? Results of a 19-year systematic lymphadenectomy experience during lung metastasectomy of colorectal cancer. Interact Cardiovasc Thorac Surg 18(4):482–487. https://doi.org/10.1093/icvts/ivt554. Epub 2014 Jan 16

    Article  PubMed  PubMed Central  Google Scholar 

  • Renaud S, Falcoz PE, Alifano M, Olland A, Magdeleinat P, Pagès O, Regnard JF, Massard G (2014b) Systematic lymph node dissection in lung metastasectomy of renal cell carcinoma: an 18 years of experience. J Surg Oncol 109(8):823–829

    Article  CAS  PubMed  Google Scholar 

  • Renaud S, Romain B, Falcoz PE et al (2015) KRAS and BRAF mutations are prognostic biomarkers in patients undergoing lung metastasectomy of colorectal cancer. Br J Cancer 112(4):720–728. https://doi.org/10.1038/bjc.2014.499

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rick O, Bokemeyer C, Weinknecht S, Schirren J et al (2004) Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer. J Clin Oncol 22(18):3713–3719

    Article  CAS  PubMed  Google Scholar 

  • Riquet M, Hidden G, Debesse B (1989) Direct lymphatic drainage of lung segments to the mediastinal nodes. An anatomic study on 260 adults. J Thorac Cardiovasc Surg 97(4):623–632

    Article  CAS  PubMed  Google Scholar 

  • Riquet M, Foucault C, Cazes A, Mitry E, Dujon A, Le Pimpec BF, Médioni J, Rougier P (2010) Pulmonary resection for metastases of colorectal adenocarcinoma. Ann Thorac Surg 89(2):375–380

    Article  PubMed  Google Scholar 

  • Rodríguez-Fuster A, Belda-Sanchis J, Aguiló R, Embun R, Mojal S, Call S, Molins L, Rivas de Andrés JJ, GECMP-CCR-SEPAR (2014) Morbidity and mortality in a large series of surgical patients with pulmonary metastases of colorectal carcinoma: a prospective multicentre Spanish study (GECMP-CCR-SEPAR). Eur J Cardiothorac Surg 45(4):671–676

    Article  PubMed  Google Scholar 

  • Röpke E (1937) Mehrjährige Heilung nach Operation eines Lungencarcinoms. Zentralbl Chir 64:803–806

    Google Scholar 

  • Roth JA (1985) Treatment of metastastic cancer to lung. In: DeVita Z, Hellman Z, Rosenberg Z (Hrsg) Cancer principles and practice of oncology, Bd 2, 2. Aufl. Lippincott, Philadelphia, S 2104–2117

    Google Scholar 

  • S3-Leitlinie Kolorektales Karzinom (2017). http://www.awmf.org/uploads/tx_szleitlinien/021-007OLl_S3_KRK_2017-12_1.pdf. Zugegriffen am 01.04.2018

  • Saito Y, Omiya H, Kohno K et al (2002) Pulmonary metastasectomy for 165 patients with colorectal carcinoma: a prognostic assessment. J Thorac Cardiovasc Surg 124(5):1007–1013

    Article  PubMed  Google Scholar 

  • Saxman SB, Nichols CR, Einhorn LH (1997) Pulmonary toxicity in patients with advanced-stage germ cell tumors receiving bleomycin with and without granulocyte colony stimulating factor. Chest 111(3):657–660

    Article  CAS  PubMed  Google Scholar 

  • Schirren J, Wassenberg D, Krysa S, Branscheid D, di Rienzo G, Drings P, Vogt-Moykopf I (1994) Metastasenchirurgie der Lunge – Indikation, Ergebnisse und prognostische Faktoren im interdisziplinären Konzept [Surgery of lung metastasis – indications, results and prognostic factors as an interdisciplinary concept]. Pneumologie 48(7):469–74. German. PMID: 7524062

    Google Scholar 

  • Schirren J, Muley T, Schneider P, Kugler C, Trainer C, Bülzebruck H, Vogt-Moykopf I (1998) Chirurgische Therapie der Lungenmetastasen. In: Drings P, Vogt-Moykopf I (Hrsg) Thoraxtumoren, Diagnostik – Staging -gegenwärtiges Therapiekonzept, 2. Aufl. Springer, Heidelberg, S 640–669

    Google Scholar 

  • Schirren J, Trainer S, Eberlein M, Lorch A, Beyer J, Bölükbas S (2012) The role of residual tumor resection in the management of nonseminomatous germ cell cancer of testicular origin. Thorac Cardiovasc Surg 60(6):405–412. https://doi.org/10.1055/s-0031-1299584. Epub 2012 Mar 1

    Article  PubMed  Google Scholar 

  • Schmoll HJ, Souchon R, Krege S et al (2004) European consensus on diagnosis and treatment of germ cell cancer: a report of the European Germ Cell Cancer Consensus Group (EGCCCG). Ann Oncol 15(9):1377–1399

    Article  CAS  PubMed  Google Scholar 

  • Schuhan C, Muley T, Dienemann H, Pfannschmidt J (2011) Survival after pulmonary metastasectomy in patients with malignant melanoma. Thorac Cardiovasc Surg 59(3):158–162

    Article  CAS  PubMed  Google Scholar 

  • Seki M, Nakagawa K, Tsuchiya S, Matsubara T, Kinoshita I, Weng SY, Tsuchiya E (1992) Surgical treatment of pulmonary metastases from uterine cervical cancer. Operation method by lung tumor size. J Thorac Cardiovasc Surg 104(4):876–81. PMID: 1405684

    Google Scholar 

  • Senkus E, Kyriakides S, Penault-Llorca F, Poortmans P, Thompson A, Zackrisson S, Cardoso F, ESMO Guidelines Working Group (2013) Primary breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(Suppl 6):vi7-23

    PubMed  Google Scholar 

  • Shu T, Bai P, Zhang R, Li S (2014) Clinical analysis and prognostic factors in 106 patients with stage Ia-IIb cervical cancer with pulmonary metastasis. Zhonghua Zhong Liu Za Zhi 36:703–707

    PubMed  Google Scholar 

  • Simpson R, Kennedy C, Carmalt H, McCaughan B, Gillett D (1997) Pulmonary resection for metastatic breast cancer. Aust N Z J Surg 67(10):717–719

    Article  CAS  PubMed  Google Scholar 

  • Sponholz S, Bölükbas S, Schirren M, Oguzhan S, Kudelin N, Schirren J (2016) Liver and lung metastases of colorectal cancer. Long-term survival and prognostic factors. Chirurg 87(2):151–156

    Article  CAS  PubMed  Google Scholar 

  • Sponholz S, Schirren M, Baldes N, Oguzhan S, Schirren J (2017) Repeat resection for recurrent pulmonary metastasis of colorectal cancer. Langenbecks Arch Surg 402(1):77–85

    Article  PubMed  Google Scholar 

  • Sponholz S, Baldes N, Schirren M, Oguzhan S, Menke H, Schirren J (2018) Sternal resection for breast cancer metastases. Thorac Cardiovasc Surg 66(2):164–169

    Article  PubMed  Google Scholar 

  • Staren ED, Salerno C, Rongione A, Witt TR, Faber LP (1992) Pulmonary resection for metastatic breast cancer. Arch Surg 127(11):1282–1284

    Article  CAS  PubMed  Google Scholar 

  • Suemitsu R, Takeo S, Kusumoto E et al (2011) Results of a pulmonary metastasectomy in patients with colorectal cancer. Surg Today 41:54–59

    Article  PubMed  Google Scholar 

  • Suzuki H, Kiyoshima M, Kitahara M, Asato Y, Amemiya R (2015) Long-term outcomes after surgical resection of pulmonary metastases from colorectal cancer. Ann Thorac Surg 99(2):435–440

    Article  PubMed  Google Scholar 

  • Tanaka F, Li M, Hanaoka N, Bando T, Fukuse T, Hasegawa S, Wada H (2005) Surgery for pulmonary nodules in breast cancer patients. Ann Thorac Surg 79(5):1711–1714. discussion 1714–5

    Article  PubMed  Google Scholar 

  • Temple LK, Brennan MF (2002) The role of pulmonary metastasectomy in soft tissue sarcoma. Semin Thorac Cardiovasc Surg 14:35–44

    Article  PubMed  Google Scholar 

  • Thomford NR, Woolner LB, Clagett OT (1965) The surgical treatment of metastatic tumors in the lungs. J Thorac Cardiovasc Surg 49:357–363

    Article  CAS  PubMed  Google Scholar 

  • Tognoni PG, Foster RS, McGraw P, Heilman D, Bihrle R, Rowland RG, Wahle GR, Einhorn LH, Donohue JP (1998) Combined post-chemotherapy retroperitoneal lymph node dissection and resection of chest tumor under the same anesthetic is appropriate based on morbidity and tumor pathology. J Urol 159(6):1833–1835

    Article  CAS  PubMed  Google Scholar 

  • Trainer S, Bergmann T, Bölükbas S, Weissbach L, Figge M, Schirren J (2008) The approach to tumors of the retrocrural mediastinum. Chirurg 79(1):26–29

    Article  CAS  PubMed  Google Scholar 

  • Treasure T (2007) Editorial comment: surgical resection of pulmonary metastases. Eur J Cardiothorac Surg 32(2):354–355

    Article  Google Scholar 

  • Treasure T, Farewell V, Macbeth F, Monson K, Williams NR, Brew-Graves C, Lees B, Grigg O, Fallowfield L, PulMiCC Trial Group (2019) Pulmonary Metastasectomy versus Continued Active Monitoring in Colorectal Cancer (PulMiCC): a multicentre randomised clinical trial. Trials 20(1):718. https://doi.org/10.1186/s13063-019-3837-y. PMID: 31831062; PMCID: PMC6909580

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tsuchiya H, Kanazawa Y, Abdel-Wanis ME et al (2002) Effect of timing of pulmonary metastases identification on prognosis of patients with osteosarcoma: the Japanese Musculoskeletal Oncology Group study. J Clin Oncol 20:3470–3477

    Article  PubMed  Google Scholar 

  • Tsukioka T, Nishiyama N, Iwata T et al (2007) Pulmonary metastasis from colorectal carcinoma with hepatic metastasis. Gen Thorac Cardiovasc Surg 55:455–460

    Article  PubMed  Google Scholar 

  • Turan T, Ureyen I, Karalok A, Tasci T, Turkmen O, Kocak O, Koe S, Tulunay G (2016) Pulmonary recurrence in patients with endometrial cancer. J Chin Med Assoc 79(4):212–220

    Article  PubMed  Google Scholar 

  • Ulivieri A, Cardillo G, Manente L, Paone G, Mancuso AP, Vigna L, Di Stasio E, Gasbarra R, Girlando S, Leone A (2015) Molecular characterization of a selected cohort of patients affected by pulmonary metastases of malignant melanoma: hints from BRAF, NRAS and EGFR evaluation. Oncotarget 6(23):19868

    Article  PubMed  PubMed Central  Google Scholar 

  • Urschel HC Jr, Razzuk MA (1986) Median sternotomy as a standard approach for pulmonary resection. Ann Thorac Surg 41:130

    Article  PubMed  Google Scholar 

  • Vogt-Moykopf I, Meyer G (1986) Surgical technique in operations on pulmonary metastases. Thorac Cardiovasc Surg 34:125–132

    Article  PubMed  Google Scholar 

  • Vogt-Moykopf I, Meyer G, Bülzebruck H (1986a) Lungenmetastasen – Therapieindikation und chirurgische Technik. MMW 128:295–300

    Google Scholar 

  • Vogt-Moykopf I, Meyer G, Merkle NM et al (1986b) Late results of surgical treatment of pulmonary metastases. Thorac Cardiovasc Surg 34:143–148

    Article  PubMed  Google Scholar 

  • Vogt-Moykopf I, Krysa S, Bülzebruck H, Schirren J (1994) Surgery for pulmonary metastases. The Heidelberg experience. Chest Surg Clin N Am 4(1):85–112

    CAS  PubMed  Google Scholar 

  • Walther HE (1948) Krebsmetastasen. Benno Schwabe & Co, Basel, S 22

    Google Scholar 

  • Weinlechner (1882) Tumoren an der Brust und deren Behandlung (Resektion der Rippen, Eröffnung der Brusthöhle, partielle Entfernung der Lunge). Wien Med Wochenschr 590:20–21

    Google Scholar 

  • Weiss L, Gilbert HA (1978) Pulmonary metastases. Hell, Boston, S 142–167

    Google Scholar 

  • Welter S et al (2007a) Prognostic impact of lymph node involvement in pulmonary metastases from colorectal cancer. Eur J Cardiothorac Surg 31:167–172

    Article  PubMed  Google Scholar 

  • Welter S, Jacobs J, Krbek T, Krebs B, Stamatis G (2007b) Long-term survival after repeated resection of pulmonary metastases from colorectal cancer. Ann Thorac Surg 84(1):203–210

    Article  PubMed  Google Scholar 

  • Welter S, Jacobs J, Krbek T, Tötsch M, Stamatis G (2008) Pulmonary metastases of breast cancer. When is resection indicated? Eur J Cardiothorac Surg 34(6):1228–1234

    Article  PubMed  Google Scholar 

  • Willis RA (1967) Pathology of tumors. Appleton Century Crafts, London, S 175

    Google Scholar 

  • Winter H, Meimarakis G, Angele MK, Hummel M, Staehler M, Hoffmann RT, Hatz RA, Löhe F (2010) Tumor infiltrated hilar and mediastinal lymph nodes are an independent prognostic factor for decreased survival after pulmonary metastasectomy in patients with renal cell carcinoma. J Urol 184(5):1888–1894

    Article  PubMed  Google Scholar 

  • Wolchok JD, Motzer RJ (2000) Management of renal cell carcinoma. Oncology (Williston Park) 14(1):29–34; discussion 34–6, 39

    CAS  Google Scholar 

  • Yamamoto K, Yoshikawa H, Shiromizu K, Saito T, Kuzuya K, Tsunematsu R et al (2004) Pulmonary metastasectomy for uterine cervical cancer: a multivariate analysis. Ann Thorac Surg 77:1179–1182

    Article  PubMed  Google Scholar 

  • Yhim HY, Han SW, Oh DY, Han W, Im SA, Kim TY, Kim YT, Noh DY, Chie EK, Ha SW, Park IA, Bang YJ (2010) Prognostic factors for recurrent breast cancer patients with an isolated, limited number of lung metastases and implications for pulmonary metastasectomy. Cancer 116(12):2890–2901

    Article  PubMed  Google Scholar 

  • Yoshimoto M, Tada K, Nishimura S, Makita M, Iwase T, Kasumi F, Okumura S, Sato Y, Nakagawa K (2008) Favourable long-term results after surgical removal of lung metastases of breast cancer. Breast Cancer Res Treat 110(3):485–491

    Article  PubMed  Google Scholar 

  • Younes R, Abrao FC, Gross J (2013) Pulmonary metastasectomy for malignant melanoma: prognostic factors for long-term survival. Melanoma Res 23(4):307–311

    Article  PubMed  Google Scholar 

  • Zabaleta J, Aguinagalde B, Fuentes MG et al (2011) Survival after lung metastasectomy for colorectal cancer: importance of previous liver metastasis as a prognostic factor. Eur J Surg Oncol 37(9):786–790

    Article  CAS  PubMed  Google Scholar 

  • Zaid HB, Parker WP, Safdar NS, Gershman B, Erwin PJ, Murad MH, Boorjian SA, Costello BA, Thompson RH, Leibovich BC (2017) Outcomes following complete surgical metastasectomy for patients with metastatic renal cell carcinoma: a systematic review and meta-analysis. J Urol 197(1):44–49

    Article  PubMed  Google Scholar 

  • Zhao Y, Li J, Li C, Fan J, Liu L (2017) Prognostic factors for overall survival after lung metastasectomy in renal cell cancer patients: a systematic review and meta-analysis. Int J Surg 41:70–77. https://doi.org/10.1016/j.ijsu.2017.03.062. Review

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stefan Sponholz .

Editor information

Editors and Affiliations

Section Editor information

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Sponholz, S., Schirren, M., Rick, O., Kugler, C., Neudecker, J., Schirren, J. (2022). Chirurgische Therapie von Lungenmetastasen. In: Schmoll, HJ. (eds) Kompendium Internistische Onkologie . Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46764-0_194-1

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-46764-0_194-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-46764-0

  • Online ISBN: 978-3-662-46764-0

  • eBook Packages: Springer Referenz Medizin

Publish with us

Policies and ethics

Navigation