Chamomile

  • Chapter
  • First Online:
Essentials of Medicinal and Aromatic Crops

Abstract

Asteraceae family member Matricaria recutita was formerly known as Marticaria chamomilla, Chamomilla recutita, and Chamomilum nobile. The objective of this comprehensive analysis was to provide an overview of Matricaria recuitta chamomile, its chemical components, and its traditional use and its nutraceuticals characteristics. Roman chamomile Chamaemelum nobil and German chamomile Marticaria recutita are two of the most well-known varieties of chamomile. Chamomile is metabolised into terpenoids and flavonoids. Chamomile is abundant in various bioactive substances, antioxidants, and phytochemicals; it also has a wide range of pharmacological and conventional properties. Analgesic, antiviral, anti-inflammatory, antiseptic, antidiabetic, antiproliferative, antibacterial, and many more conditions are treated using chamomile leaves, flowers, and stems. The use of chamomile in the treatment of chronic illnesses like diabetes mellitus appears to be successful since it is a rich source of terpenoids and phenolic chemicals. Each essential oil performs a little bit differently since they have distinct active components. For instance, Citronella oil, which is derived from Cymbopogon nardus, is mostly used as a mosquito repellent. Jasmine oil, which is derived from Jasminum officinale, may be used as an antidepressant and an antibacterial. Geranium oil, which is derived from Pelargonium graveolens, can decrease inflammation, cure acne, and ease anxiety.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Blamey, M., Fitter, R., & Fitter, A. (1978). The Wild Flowers of Britain and Northern Europe. Book Club Associates.

    Google Scholar 

  2. McKay, D. L., & Blumberg, J. B. (2006). A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(7), 519–530.

    Article  CAS  Google Scholar 

  3. Issac, O. J. P. (1989). Recent progress in chamomile research-medicines of plant origin in modern therapy. Prague, Czeco-Slovakia, 7, PMC3210003.

    Google Scholar 

  4. Sharafzadeh, S., & Alizadeh, O. (2011). German and Roman chamomile. Journal of Applied Pharmaceutical Science, 2, 1–5.

    Google Scholar 

  5. Singh, O., et al. (2011). Chamomile (Matricaria chamomilla L.): an overview. Pharmacognosy Reviews, 5(9), 82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. El Joumaa, M. M., & Borjac, J. M. (2022). Matricaria chamomilla: A valuable insight into recent advances in medicinal uses and pharmacological activities. Phytochemistry Reviews, 21, 1–28.

    Article  Google Scholar 

  7. Upadhyay, R., et al. (2016). New agro-technology to increase productivity of chamomile (Matricaria chamomilla L.). Industrial Crops and Products, 89, 10–13.

    Article  CAS  Google Scholar 

  8. Gupta, V., et al. (2010). Pharmacological potential of Matricaria recutita-A review. International Journal of Pharmaceutical Sciences and Drug Research, 2(1), 12–16.

    Google Scholar 

  9. Kumar, S., Das, M., Singh, A., Ram, G., Mallavarapu, G. R., & Ramesh, S. (2001). Journal of Medicinal and Aromatic Plant Studies, 23, 617–623.

    CAS  Google Scholar 

  10. Tyihak, E., Sarkany-Kiss, I., & Verzar-Petri, G. J. P. (1962). Pflanzenchemische Untersuchung der Apigeninglykoside der echten Kamille (Matricaria chamomilla L.). Pharmazie, 17, 301–304.

    CAS  Google Scholar 

  11. Mann, C., et al. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455. Herbs, Spices, and Medicinal Plants: Recent Advances in Botany, Horticulture, and Pharmacology, 1992(1), 235.

    Google Scholar 

  12. Bradley, P. R. (1992). British herbal compendium. Volume 1. A handbook of scientific information on widely used plant drugs. Companion to Volume 1 of the British Herbal Pharmacopoeia. British Herbal Medicine Association.

    Google Scholar 

  13. Zargaran, A., et al. (2016). A review on the management of migraine in the Avicenna’s Canon of Medicine. Neurological Sciences, 37, 471–478.

    Article  PubMed  Google Scholar 

  14. Das, M. (2014). Chamomile: medicinal, biochemical, and agricultural aspects. CRC Press.

    Book  Google Scholar 

  15. Chauhan, E. S., & Jaya, A. (2017). Chamomile an ancient aromatic plant-A review. Journal of Ayurveda Medical Sciences, 2(4), 251–255.

    Article  Google Scholar 

  16. Svab, J. J. H. P. (1979). New aspects of cultivating camomile. Herba Polonica, 25(1), 35–39.

    Google Scholar 

  17. Mills, S. Y. (1991). The essential book of herbal medicine. Arkana Penguin.

    Google Scholar 

  18. Chandra, V. (1973). Cultivation of plants for perfumery industry at Lucknow. Indian Perfumer, 16(1), 40–44.

    Google Scholar 

  19. Franz, C., et al. (2007). Study on the assessment of plants/herbs, plant/herb extracts and their naturally or synthetically produced components as ‘additives’ for use in animal production. EFSA Supporting Publications, 4(4), 1–297.

    Google Scholar 

  20. Lawrence, B. M. (1996). Progress in essential oils-mandarin oil, fennel oil and artemisia annua oil. Perfumer and Flavorist, 21(2), 25–32.

    CAS  Google Scholar 

  21. Franke, R., & Schilcher, H. (2005). Chamomile: industrial profiles. CRC press.

    Book  Google Scholar 

  22. Dettmer, B., & Sauer, T. (2014). Regionalökonomische Auswirkungen eines geplanten Pumpspeicherkraftwerks: Eine Input-Output-Analyse für den Freistaat Thüringen. Zeitschrift für Energiewirtschaft, 4(38), 255–268.

    Article  Google Scholar 

  23. Zalecki, R. (1971). Cultivation and fertilizing of the tetraploid Matricaria chamomilla LI The sowing time. Herba Polonica, 17, 367–375.

    Google Scholar 

  24. Dutta, P., & Singh, A. (1964). Effect of different spacings on fresh flower and oil yield of Matricaria chamomilla. Indian Journal of Agronomy, 9, 1–12.

    Google Scholar 

  25. Franke, R., & Hannig, H. J. (2012). Kamille (Matricaria recutita L.). Handbuch des Arznei-und Gewürzpflanzenbaus, 4, 618–648.

    Google Scholar 

  26. Singh, L. B. (1970). Utilisation of saline-alkali soils for agro-industry without prior reclamation. Economic Botany, 24(4), 439–442.

    Article  Google Scholar 

  27. Kerches, J. (1966). Experiments with the cultivation of chamomile (Matricaria chamomilla). Herba Hungarica, 5, 141–147.

    Google Scholar 

  28. Reichling, J., Beiderbeck, R., & Becker, H. (1979). Vergleichende Untersuchungen über sekundäre Inhaltsstoffe bei Pflanzentumoren, Blüte, Kraut und Wurzel von Matricaria chamomilla L. Planta Medica, 36(8), 322–332.

    Article  CAS  Google Scholar 

  29. Handa, H., & Kaul, M. K. (1997). Supplement to cultivation and utilization of aromatic plants. Regional Research Laboratory/Council of Scientific & Industrial Research.

    Google Scholar 

  30. Park, Y., et al. (2003). Characterization of salicylic acid-induced genes in Chinese cabbage. Plant Cell Reports, 21, 1027–1034.

    Article  CAS  PubMed  Google Scholar 

  31. Gunes, A., et al. (2007). Salicylic acid induced changes on some physiological parameters symptomatic for oxidative stress and mineral nutrition in maize (Zea mays L.) grown under salinity. Journal of Plant Physiology, 164(6), 728–736.

    Article  CAS  PubMed  Google Scholar 

  32. Horváth, E., Szalai, G., & Janda, T. (2007). Induction of abiotic stress tolerance by salicylic acid signaling. Journal of Plant Growth Regulation, 26, 290–300.

    Article  Google Scholar 

  33. Vanacker, H., et al. (2001). A role for salicylic acid and NPR1 in regulating cell growth in Arabidopsis. The Plant Journal, 28(2), 209–216.

    Article  CAS  PubMed  Google Scholar 

  34. Pastı́rová, A., Repčák, M., & Eliašová, A. (2004). Salicylic acid induces changes of coumarin metabolites in Matricaria chamomilla L. Plant Science, 167(4), 819–824.

    Article  Google Scholar 

  35. Stanojevic, L. P., et al. (2016). Chemical composition, antioxidant and antimicrobial activity of chamomile flowers essential oil (Matricaria chamomilla L.). Journal of Essential Oil Bearing Plants, 19(8), 2017–2028.

    Article  CAS  Google Scholar 

  36. Salehi, A., & Hazrati, S. (2017). How essential oil content and composition fluctuate in German chamomile flowers during the day? Journal of Essential Oil Bearing Plants, 20(3), 622–631.

    Article  CAS  Google Scholar 

  37. Bucko, D., & Salamon, I. (2006). The essential oil quality of chamomile, Matricaria recutita L., after its large-scale distillation. in I International Symposium on Chamomile Research. Development and Production, 749, 269–273.

    Google Scholar 

  38. Frabboni, L., et al. (2019). Bio-herbicidal effects of oregano and rosemary essential oils on chamomile (Matricaria chamomilla L.) crop in organic farming system. Agronomy, 9(9), 475.

    Article  CAS  Google Scholar 

  39. Homami, S. S., et al. (2016). Comparative studies of different extraction methods of essential oil from Matricaria recutita L. in Iran. Journal of the Chilean Chemical Society, 61(2), 2982–2984.

    Article  CAS  Google Scholar 

  40. EL-Hefny, M., et al. (2019). Essential and recovery oils from Matricaria chamomilla flowers as environmentally friendly fungicides against four fungi isolated from cultural heritage objects. Processes, 7(11), 809.

    Article  CAS  Google Scholar 

  41. Pirzad, A., et al. (2006). Essential oil content and composition of German chamomile (Matricaria chamomilla L.) at different irrigation regimes. Journal of Agronomy, 5(3), 451–455.

    Article  Google Scholar 

  42. Amiri, S., & Sharafzadeh, S. (2014). Essential oil components of German chamomile cultivated in Firoozabad, Iran. Oriental Journal of Chemistry, 30(1), 365–367.

    Article  CAS  Google Scholar 

  43. Kawthar, A., Ashour, H., & Fatma, S. J. (2017). Growth characters and some chemical constituents of Matricaria chamomilla L. plants in relation to green manure and compost fertilizer in sandy soil. Middle East Journal, 6(1), 76–86.

    Google Scholar 

  44. Stahl, E. (1954). Über das Cham-Azulen und dessen Vorstufen, III. Mitteil.: Zur Konstitution der Cham-Azulencarbonsäure., 87(11), 1626–1628.

    CAS  Google Scholar 

  45. Council, N. R. (1930). Food chemicals codex: First supplement to the (2nd ed.). The Convention.

    Google Scholar 

  46. Mwaniki, J. M. (2015). Analysis of blue chamomile essential oil produced by multi-solvent solvent extraction clevenger distillation method. Africa Journal of Physical Sciences ISSN, 2(1), 1–10.

    Google Scholar 

  47. Taraj, K., et al. (2017). Eco-extraction of albanian chamomile essential oils by liquid Co2 at different temperatures and characterisation by FTIR spectroscopy. Journal of Environmental Protection and Ecology, 18(1), 117–124.

    CAS  Google Scholar 

  48. Noori, H., & Khajenoori, M. (2013). Subcritical Water Extraction of Essential Oils from Matricaria Chamomilla L. International Journal of Engineering, 26(5), 489–494.

    Google Scholar 

  49. Al-Dabbagh, B., et al. (2019). Antioxidant and anticancer activities of chamomile (Matricaria recutita L.). BMC Research Notes, 12(1), 1–8.

    Article  Google Scholar 

  50. El-Shhat, A., et al. (2021). Effect of dietary addition of chamomile flower (Matericaria chamomilla L.) powder on productive performance. Hatching Traits and Economic Efficiency of Sudani Duck Breeders., 12(3), 119–124.

    Google Scholar 

  51. Pino, J. A., et al. (2002). Essential oil of chamomile Chamomilla recutita (L.) Rausch. from Iran. Journal of Essential Oil Research, 14(6), 407–408.

    Article  CAS  Google Scholar 

  52. Redaelli, C., Formentini, L., & Santaniello, E. (1981). HPLC determination of coumarins in Matricaria chamomilla. Planta Medica, 43(12), 412–413.

    Article  CAS  PubMed  Google Scholar 

  53. Achterrath-Tuckermann, U., et al. (1980). Pharmacological investigations with compounds of chamomile. V. Investigations on the spasmolytic effect of compounds of chamomile and Kamillosan on the isolated guinea pig ileum, 39(1), 38–50.

    Google Scholar 

  54. Guenther, E. (1952). The essential oils. In E. Robert (Ed.), Florida (Vol. 5). Krieger Publishing Company.

    Google Scholar 

  55. Jellinek, J. J. P. C. A. (1984). α-Bisabolol–an agent, anti-inflammatory pour products cosmetique. Perfume Cosmet Aromes, 57, 55–57.

    CAS  Google Scholar 

  56. Duke, J. A. (1990). CRC Handbook of medicinal herbs. International Clinical Psychopharmacology, 5(1), 74.

    Article  Google Scholar 

  57. Schilcher, H. (1973). Recent knowledge in quality evaluation of camomile blossoms respectively camomile oil. 2. Quality evaluation of the volatile oil in Flores Chamomillae. Grading of commercial camomiles into 4 respectively 5 chemical types. Planta Medica, 23(2), 132–144.

    Article  CAS  PubMed  Google Scholar 

  58. Faehnrich, B., et al. (2013). Self-incompatibility and male sterility in six Matricaria recutita varieties. Journal of Applied Botany and Food Quality, 86(1).

    Google Scholar 

  59. Buswell, J. A., & Chen, M. J. (2005). Cultivation, biochemical, molecular biological and medical aspects of the culinary-medicinal straw mushroom Volvariella volvacea (Bull.: Fr.) Singer (Agaricomycetideae). International Journal of Medicinal Mushrooms, 7(1&2), 157–166.

    Article  CAS  Google Scholar 

  60. Srivastava, S. (2015). Flora of cold deserts of Western Himalaya. Botanical Survey of India.

    Google Scholar 

  61. Solouki, M., et al. (2008). Study of genetic diversity in Chamomile (Matricaria chamomilla) based on morphological traits and molecular markers. Scientia Horticulturae, 117(3), 281–287.

    Article  CAS  Google Scholar 

  62. Pirkhezri, M., Hassani, M., & Hadian, J. (2010). Genetic diversity in different populations of Matricaria chamomilla l. Growing in southwest of Iran, based on morphological. Research Journal of Medicinal Plant, 4(1), 1–13.

    Article  CAS  Google Scholar 

  63. Wagner, C., et al. (2005). Molecular analyses on the genetic diversity and inheritance of (−)-α-bisabolol and chamazulene content in tetraploid chamomile (Chamomilla recutita (L.) Rausch.). Plant Science, 169(5), 917–927.

    Article  CAS  Google Scholar 

  64. Otto, L.-G., et al. (2017). Use of genoty**-by-sequencing to determine the genetic structure in the medicinal plant chamomile, and to identify flowering time and alpha-bisabolol associated SNP-loci by genome-wide association map**. Acta Scientiarum Polonorum. Hortorum Cultus, 18, 1–18.

    Google Scholar 

  65. Okoń, S., Surmacz-Magdziak, A., & Paczos-Grzęda, E. (2013). Genetic diversity among cultivated and wild chamomile germplasm based on ISSR analysis. Acta Scientiarum Polonorum. Hortorum Cultus, 12(2), 43–50.

    Google Scholar 

  66. Tsivelika, N., et al. (2018). Phenotypic variation of wild Chamomile (Matricaria chamomilla L.) populations and their evaluation for medicinally important essential oil. Biochemical Systematics and Ecology, 80, 21–28.

    Article  CAS  Google Scholar 

  67. Ahmadi, H., et al. (2014). Assessment of the genetic variation of chamomile (Matricaria chamomilla L.) populations using phytochemical, morphological and ISSR markers. Biochemical Systematics and Ecology, 54, 190–197.

    Article  CAS  Google Scholar 

  68. Adeli, N., et al. (2013). Evaluation of essential oil yield, morphological and phenological traits in some populations of two Chamomile species (Matricaria recutita and M. aurea). Journal of Medicinal Plants and By-product, 2(2), 153–158.

    Google Scholar 

  69. D’Andrea, L. (2002). Variation of morphology, yield and essential oil components in common chamomile (Chamomilla recutita (L.) Rauschert) cultivars Grown in Southern Italy. Journal of Herbs, Spices & Medicinal Plants, 9(4), 359–365.

    Article  Google Scholar 

  70. Singh, S., et al. (2007). Genetic divergence in German chamomile [Chamomilla recutita (L.) Rauch.]. Journal of Spices and Aromatic Crops, 16(2), 125–128.

    Google Scholar 

  71. Lal, R. K., et al. (2019). Induced polygenic variations through γ-rays irradiation and selection of novel genotype in chamomile (Chamomilla recutita [L.] Rauschert). International Journal of Radiation Biology, 95(9), 1242–1250.

    Article  CAS  PubMed  Google Scholar 

  72. Irmisch, S., et al. (2012). The organ-specific expression of terpene synthase genes contributes to the terpene hydrocarbon composition of chamomile essential oils. BMC Plant Biology, 12(1), 1–13.

    Article  Google Scholar 

  73. Golparvar, A., & Pirbalouti, A. G. (2011). Genetic improvement of essence percent and dry flower yield using indirect selection in German chamomile (Matricaria chamomilla L.). Journal of Medicinal Herbs, 1(4), 33–40.

    Google Scholar 

  74. Oravec, V., Sr., Oravec, V., Jr., & Oravec, V. (2006). Breeding of bisabolol diploid and tetraploid varieties of chamomile in slovakia. In I international symposium on chamomile research, development and production (Vol. 749). ISHS.

    Google Scholar 

  75. Otto, L. G., et al. (2015). Towards breeding of triploid chamomile (Matricaria recutita L.)–Ploidy variation within German chamomile of various origins. Plant Breeding, 134(4), 485–493.

    Article  Google Scholar 

  76. Albrecht, S., Sonnenschein, M., & Plescher, A. J. (2016). Breeding of a high yielding chamomile variety (Matricaria recutita L.) with improved traits for machine harvesting. Julius-Kühn-Archiv, 453, 135.

    Google Scholar 

  77. Tai, Y., et al. (2020). Analysis of terpenoid biosynthesis pathways in German chamomile (Matricaria recutita) and Roman chamomile (Chamaemelum nobile) based on co-expression networks. Genomics, 112(2), 1055–1064.

    Article  CAS  PubMed  Google Scholar 

  78. Ling, C., et al. (2020). Cloning and functional analysis of three aphid alarm pheromone genes from German chamomile (Matricaria chamomilla L.). Plant Science, 294, 110463.

    Article  CAS  PubMed  Google Scholar 

  79. Wang, H.-M., et al. (2017). In vitro regeneration, Agrobacterium-mediated transformation, and genetic assay of chalcone synthase in the medicinal plant Echinacea pallida. Microchemical Journal, 130, 117–130.

    CAS  Google Scholar 

  80. Mahgoub, Y. A., et al. (2020). Near-infrared spectroscopy combined with chemometrics for quality control of German chamomile (Matricaria recutita L.) and detection of its adulteration by related toxic plants. Microchemical Journal, 158, 105153.

    Article  CAS  Google Scholar 

  81. Guzelmeric, E., et al. (2017). Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis. Journal of Pharmaceutical and Biomedical Analysis, 132, 35–45.

    Article  CAS  PubMed  Google Scholar 

  82. Chauhan, R., et al. (2022). A comprehensive review on biology, genetic improvement, agro and process technology of German chamomile (Matricaria chamomilla L.). Plants, 11(1), 29.

    Article  CAS  Google Scholar 

  83. Kreuter, M. H. (2013). Composition containing oils of chamomile flower and black cumin with reduced endotoxins. Google Patents.

    Google Scholar 

  84. Henderson, A. (2015). Oil blend for skin treatment. Google Patents.

    Google Scholar 

  85. Oltarshevskaya, N. D., Savilova, L. B., & Krichevsky, G. E. (2013). Hemostatic dressing comprising extract of chamomile and nettle. Google Patents.

    Google Scholar 

  86. Mericli, A. H. (1990). The lipophilic compounds of a Turkish Matricaria chamomilla variety with no chamazulene in the volatile oil. International Journal of Crude Drug Research, 28(2), 145–147.

    Article  CAS  Google Scholar 

  87. Kumar, S., et al. (2001). Composition of the essential oils of the flowers, shoots and roots of two cultivars of Chamomilla recutita. Journal of Medicinal and Aromatic Plant Sciences, 23(4), 617–623.

    CAS  Google Scholar 

  88. Subiza, J., et al. (1990). Allergic conjunctivitis to chamomile tea. Annals of Allergy, 65(2), 127–132.

    CAS  PubMed  Google Scholar 

  89. Jakovlev, V., et al. (1979). Pharmacological investigations with compounds of chamomile ii. new investigations on the antiphlogistic effects of (-)-alpha-bisabolol and bisabolol oxides (author's transl). Planta Medica, 35(2), 125–140.

    Article  CAS  PubMed  Google Scholar 

  90. Owlia, P., et al. (2007). Retardation of biofilm formation with reduced productivity of alginate as a result of Pseudomonas aeruginosa exposure to Matricaria chamomilla essential oil. Pharmacognosy Magazine, 3(10), 83–89.

    CAS  Google Scholar 

  91. Kazemi, M. (2015). Chemical composition and antimicrobial activity of essential oil of Matricaria recutita. Journal of Food Properties, 18(8), 1784–1792.

    Article  CAS  Google Scholar 

  92. Silva, N., et al. (2012). Antimicrobial activity and phytochemical analysis of crude extracts and essential oils from medicinal plants. Natural Product Research, 26(16), 1510–1514.

    Article  CAS  PubMed  Google Scholar 

  93. Chouhan, S., Sharma, K., & Guleria, S. J. M. (2017). Antimicrobial activity of some essential oils—present status and future perspectives. Medicines, 4(3), 58.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Owlia, P., Saderi, H., & Rasooli, I. (2007). Antistreptococcal and antioxidant activity of essential oil from Matricaria chamomilla L. Research Journal of Biological Sciences, 2, 155–160.

    Google Scholar 

  95. Sakkas, H., et al. (2018). Antibacterial efficacy of commercially available essential oils tested against drug-resistant gram-positive pathogens. Applied Sciences, 8(11), 2201.

    Article  CAS  Google Scholar 

  96. Abdoul-Latif, F. M., et al. (2011). Antimicrobial and antioxidant activities of essential oil and methanol extract of Matricaria chamomilla L. from Djibouti. Journal of Medicinal Plants Research, 5(9), 1512–1517.

    Google Scholar 

  97. Shakya, V. K., et al. (2019). A relative assessment of essential oil of Chrysopogon zizanioides and Matricaria chamomilla along with calcium hydroxide and chlorhexidine gel against Enterococcus faecalis in ex vivo root canal models. Journal of Conservative Dentistry: JCD, 22(1), 34.

    CAS  PubMed  PubMed Central  Google Scholar 

  98. Satyal, P., Shrestha, S., & Setzer, W. N. (2015). Composition and bioactivities of an (E)-β-farnesene chemotype of chamomile (Matricaria chamomilla) essential oil from Nepal. Natural Product Communications, 10(8), 1934578X1501000835.

    Article  CAS  Google Scholar 

  99. Hartmann, K. C., & Onofre, S. B. (2010). Atividade antimicrobiana de óleos essenciais da camomila (Matricaria chamomilla L.). Saúde E Pesquisa, 3, 3.

    Google Scholar 

  100. Höferl, M., et al. (2020). Biological activity of Matricaria chamomilla essential oils of various chemotypes. Planta Medica International Open, 7(03), e114–e121.

    Article  Google Scholar 

  101. Roby, M. H. H., et al. (2013). Antioxidant and antimicrobial activities of essential oil and extracts of fennel (Foeniculum vulgare L.) and chamomile (Matricaria chamomilla L.). Industrial Crops and Products, 44, 437–445.

    Article  CAS  Google Scholar 

  102. Ismail, M. C., et al. (2013). Synergistic interaction between chamomile flower (Matricaria chamomilla L.) extracts and tetracycline against wound infection bacteria. Al-Nahrain Journal of Science, 16(3), 191–195.

    Google Scholar 

  103. El Mihyaoui, A., et al. (2022). Chamomile (Matricaria chamomilla L.): A review of ethnomedicinal use, phytochemistry and pharmacological uses. Life, 12(4), 479.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Abdalla, R. M., & Abdelgadir, A. E. (2016). Antibacterial activity and phytochemical constituents of Cinnamomum verum and Matricaria chamomilla from Sudan. Bio Bulletin, 2(2), 01-0.

    Google Scholar 

  105. Mariod, A. A., Kakil, E. S., & Elneel, Y. F. H. (2019). Antibacterial activity of Zingiber officinale, Matricaria chamomilla and Nigella sativa extractions on the growth of pathogenic bacteria isolated from different clinical specimens. Acta Scientific Nutritional Health, 3, 26–32.

    Google Scholar 

  106. Malm, A., et al. (2015). Anti-Helicobacter pylori activity in vitro of chamomile flowers, coneflower herbs, peppermint leaves and thyme herbs–a preliminary report. Current Issues in Pharmacy and Medical Sciences, 28(1), 30–32.

    Article  CAS  Google Scholar 

  107. Carvalho, A., et al. (2014). Avaliação da atividade antibacteriana de extratos etanólico e de ciclohexano a partir das flores de camomila (Matricaria chamomilla L.). Revista Brasileira de Plantas Medicinais, 16, 521–526.

    Article  Google Scholar 

  108. Sharifzadeh, A., & Shokri, H. J. (2016). Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans. Avicenna Journal of Phytomedicine, 6(2), 215.

    CAS  PubMed  PubMed Central  Google Scholar 

  109. Mekonnen, A., et al. (2016). In vitro antimicrobial activity of essential oil of Thymus schimperi, Matricaria chamomilla, Eucalyptus globulus, and Rosmarinus officinalis. International Journal of Microbiology Research, 2016, 9545693.

    Google Scholar 

  110. Boudıeb, K., et al. (2018). Phytochemical characterization and antimicrobial potentialities of two medicinal plants, Chamaemelum nobile (L.) All and Matricaria chamomilla (L.). International Journal of Innovative Science and Research Technology, 2, 126–139.

    Google Scholar 

  111. Hameed, R. H., Mohammed, G. J., & Hameed, I. H. (2018). Matricaria chamonbmilla: Bioactive compounds of methanolic fruit extract using GC-MS and FTIR techniques and determination of its antimicrobial properties. Indian Journal of Public Health Research & Development, 9(3), 223–228.

    Article  Google Scholar 

  112. Lavanya, J., et al. (2016). Antioxidant and antimicrobial activity of selected medicinal plants against human oral pathogens. International Journal of Pharmacy and Pharmaceutical Sciences, 8(9), 71–78.

    Article  CAS  Google Scholar 

  113. Cvetanović, A., et al. (2015). Antioxidant and biological activity of chamomile extracts obtained by different techniques: perspective of using superheated water for isolation of biologically active compounds. Industrial Crops and Products, 65, 582–591.

    Article  Google Scholar 

  114. Hosseinpour, M., et al. (2013). Antiproliferative effects of Matricaria chamomilla on Saccharomyces cerevisiae. Journal of HerbMed Pharmacology, 2(2), 49–51.

    Google Scholar 

  115. Rahman, H., & Chandra, A. (2015). Microbiologic evaluation of matricaria and chlorhexidine against E. faecalis and C. albicans. Indian Journal of Dentistry, 6(2), 60.

    Article  PubMed  PubMed Central  Google Scholar 

  116. Osman, M. Y., et al. (2016). Screening for antioxidant, antifungal, and antitumor activities of aqueous extracts of chamomile (Matricaria chamomilla). Egyptian Pharmaceutical Journal, 15(2), 55.

    Article  Google Scholar 

  117. Seyedjavadi, S. S., et al. (2019). Isolation, functional characterization, and biological properties of MCh-AMP1, a novel antifungal peptide from Matricaria chamomilla L. Chemical Biology & Drug Design, 93(5), 949–959.

    Article  CAS  Google Scholar 

  118. Hajaji, S., et al. (2018). Leishmanicidal activity of α-bisabolol from Tunisian chamomile essential oil. Parasitology Research, 117, 2855–2867.

    Article  PubMed  Google Scholar 

  119. Hajaji, S., et al. (2018). Anthelmintic activity of Tunisian chamomile (Matricaria recutita L.) against Haemonchus contortus. Journal of Helminthology, 92(2), 168–177.

    Article  CAS  PubMed  Google Scholar 

  120. Mansour, S. A., et al. (2015). Toxicity of essential plant oils, in comparison with conventional insecticides, against the desert locust, Schistocerca gregaria (Forskål). Industrial Crops and Products, 63, 92–99.

    Article  CAS  Google Scholar 

  121. Afify, A. E.-M. M., Ali, F. S., & Turky, A. F. (2012). Control of Tetranychus urticae Koch by extracts of three essential oils of chamomile, marjoram and Eucalyptus. Asian Pacific Journal of Tropical Biomedicine, 2(1), 24–30.

    Article  Google Scholar 

  122. Pirali-Kheirabadi, K., & Razzaghi-Abyaneh, M. (2007). Biological activities of chamomile (Matricaria chamomile) flowers’ extract against the survival and egg laying of the cattle fever tick (Acari Ixodidae). Journal of Zhejiang University Science B, 8(9), 693–696.

    Article  PubMed  PubMed Central  Google Scholar 

  123. del Carmen Romero, M., et al. (2012). Activity of Matricaria chamomilla essential oil against anisakiasis. Phytomedicine, 19(6), 520–523.

    Article  Google Scholar 

  124. Hajaji, S., et al. (2017). Correlation of radical-scavenging capacity and amoebicidal activity of Matricaria recutita L.(Asteraceae). Experimental Parasitology, 183, 212–217.

    Article  PubMed  Google Scholar 

  125. Váradyová, Z., et al. (2018). Ovicidal and larvicidal activity of extracts from medicinal-plants against Haemonchus contortus. Experimental Parasitology, 195, 71–77.

    Article  PubMed  Google Scholar 

  126. Al-Mekhlafi, F. A., et al. (2021). Target and non-target effects of Foeniculum vulgare and Matricaria chamomilla combined extract on Culex pipiens mosquitoes. Saudi Journal of Biological Sciences, 28(10), 5773–5780.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  127. Al-Mekhlafi, F. A., et al. (2020). Inhibition of the growth and development of mosquito larvae of Culex pipiens L.(Diptera: Culicidae) treated with extract from flower of Matricaria chamomilla (Asteraceae). Entomological Research, 50(3), 138–145.

    Article  CAS  Google Scholar 

  128. Villa-Rodriguez, J., et al. (2015). German Chamomile (Matricaria chamomilla) Extract and Its Major Polyphenols Inhibit Intestinal α-glycosidases in vitro. The FASEB Journal, 29, LB323.

    Article  Google Scholar 

  129. Hwang, S. H., et al. (2018). Evaluation of aldose reductase, protein glycation, and antioxidant inhibitory activities of bioactive flavonoids in Matricaria recutita L. and their structure-activity relationship. Journal of Diabetes Research, 2018, 3276162.

    Article  PubMed  PubMed Central  Google Scholar 

  130. Ali, E. M. (2013). Phytochemical composition, antifungal, antiaflatoxigenic, antioxidant, and anticancer activities of Glycyrrhiza glabra L. and Matricaria chamomilla L. essential oils. Journal of Medicinal Plant Research, 7(29), 2197–2207.

    Article  CAS  Google Scholar 

  131. Romeilah, R. M. (2009). Anticancer and antioxidant activities of Matricaria chamomilla L. and Marjorana hortensis essential oils. Research Journal of Medicine and Medical Sciences, 4(2), 332–339.

    CAS  Google Scholar 

  132. Kamali, A. M., et al. (2014). In vitro cytotoxic activity of Matricaria chamomilla root extract in Human breast cancer cell line MCF-7. Life Science Journal, 11, 403–406.

    Google Scholar 

  133. Fraihat, A., et al. (2018). Inhibitory effects of methanol extracts of selected plants on the proliferation of two human melanoma cell lines. Tropical Journal of Pharmaceutical Research, 17(6), 1081–1086.

    Article  CAS  Google Scholar 

  134. Wu, Y. N., Xu, Y., & Yao, L. (2012). Anti-inflammatory and anti-allergic effects of German chamomile (Matricaria chamomilla L.). Journal of Essential Oil Bearing Plants, 15(1), 75–83.

    Article  Google Scholar 

  135. Asadi, Z., et al. (2020). Anti-inflammatory effects of Matricaria chamomilla extracts on BALB/c mice macrophages and lymphocytes. Iranian Journal of Allergy, Asthma and Immunology, 19(S1), 63–73.

    PubMed  Google Scholar 

  136. Singh, K. G., Sonia, S., & Konsoor, N. (2018). In-vitro and ex-vivo studies on the antioxidant, anti-inflammatory and antiarthritic properties of Camellia sinensis, Hibiscus rosa sinensis, Matricaria chamomilla, Rosa SP., Zingiber officinale tea extracts. Inflammation, 49, 50.

    Google Scholar 

  137. Nargesi, S., et al. (2018). The effects of Matricaria chamomilla L. hydroalcoholic extract on atherosclerotic plaques, antioxidant activity, lipid profile and inflammatory indicators in rats. Biomedical Research and Therapy, 5(10), 2752–2761.

    Article  Google Scholar 

  138. Banchio, E., et al. (2005). Quantitative variations in the essential oil of Minthostachys mollis (Kunth.) Griseb. in response to insects with different feeding habits. Journal of Agricultural and Food Chemistry, 53(17), 6903–6906.

    Article  CAS  PubMed  Google Scholar 

  139. Ghasemi, M., et al. (2016). Increase of Chamazulene and α-Bisabolol contents of the essential oil of german chamomile (Matricaria chamomilla L.) using salicylic acid treatments under normal and heat stress conditions. Food, 5(3), 56.

    Article  Google Scholar 

  140. **aomeng, L., et al. (2018). Effects of 5-aminolevulinic acid on the photosynthesis, antioxidant system, and α-bisabolol content of Matricaria recutita. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 46(2), 418–425.

    Article  Google Scholar 

  141. Kusano, M., et al. (2011). Metabolomic approaches toward understanding nitrogen metabolism in plants. Journal of Experimental Botany, 62(4), 1439–1453.

    Article  CAS  PubMed  Google Scholar 

  142. Matt, P., et al. (2002). Decreased Rubisco activity leads to dramatic changes of nitrate metabolism, amino acid metabolism and the levels of phenylpropanoids and nicotine in tobacco antisense RBCS transformants. The Plant Journal, 30(6), 663–677.

    Article  CAS  PubMed  Google Scholar 

  143. Repčák, M., Imrich, J., & Franeková, M. (2001). Umbelliferone, a stress metabolite of Chamomilla recutita (L.) Rauschert. Journal of Plant Physiology, 158(8), 1085–1087.

    Article  Google Scholar 

  144. Maksymiec, W. J. A. P. P. (2007). Signaling responses in plants to heavy metal stress. Acta Physiologiae Plantarum, 29, 177–187.

    Article  CAS  Google Scholar 

  145. Kováčik, J., et al. (2006). Matricaria chamomilla is not a hyperaccumulator, but tolerant to cadmium stress. Plant Growth Regulation, 50, 239–247.

    Article  Google Scholar 

  146. Prokop’ev, I., et al. (2014). Impact of urban anthropogenic pollution on seed production, morphological and biochemical characteristics of chamomile. Matricaria chamomila L., 45, 18–23.

    Google Scholar 

  147. Kessler, A., & Baldwin, I. T. (2002). Plant responses to insect herbivory: the emerging molecular analysis. Annual Review of Plant Biology, 53(1), 299–328.

    Article  CAS  PubMed  Google Scholar 

  148. Mondal, P. Biosynthesis and Regulation of Terpene Production in Accessions of Chamomile (Matricaria recutita L.). Ph.D. Thesis, Martin-Luther-Universität Halle-Wittenberg, Halle, Germany, 2020

    Google Scholar 

  149. Raal, A., et al. (2011). Content and composition of essential oils in some Asteraceae species. Proceedings of the Estonian Academy of Sciences, 60(1), 55.

    Article  CAS  Google Scholar 

  150. Orav, A., Kailas, T., & Ivask, K. (2001). Volatile constituents of Matricaria recutita L. from Estonia. In Proceedings-Estonian academy of sciences chemistry. TRUEKITUD OU.

    Google Scholar 

  151. Mohammad, R., et al. (2010). Effects of planting date and seedling age on agro-morphological characteristics, essential oil content and composition of German chamomile (Matricaria chamomilla L.) grown in Belgium. Industrial Crops and Products, 31(1), 145–152.

    Article  Google Scholar 

  152. Mertens, D., et al. (2021). Predictability of biotic stress structures plant defence evolution. Trends in Ecology & Evolution, 36(5), 444–456.

    Article  Google Scholar 

  153. Sarrou, E., et al. (2016). Metabolite profiling and antioxidative activity of Sage (Salvia fruticosa Mill.) under the influence of genotype and harvesting period. Industrial Crops and Products, 94, 240–250.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2023 The Author(s), under exclusive license to Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Parveen, A., Perveen, S., Naz, F., Ahmad, M., Khalid, M. (2023). Chamomile. In: Zia-Ul-Haq, M., Abdulkreem AL-Huqail, A., Riaz, M., Farooq Gohar, U. (eds) Essentials of Medicinal and Aromatic Crops. Springer, Cham. https://doi.org/10.1007/978-3-031-35403-8_39

Download citation

Publish with us

Policies and ethics

Navigation