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Tumor Niche Disruption and Metastasis: The Role of Epithelial-Mesenchymal Transition (EMT)

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Molecular and Cell Biology of Cancer

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Abstract

In this chapter you will learn that, besides the initial oncogenic mutations that trigger tumorigenesis, cancer cells must have additional molecular changes and morphological modifications in order to metastasize and become malignant. One of the mechanisms that tumor cells may undergo to achieve this state is the Epithelial-Mesenchymal Transition (EMT). After giving a global perspective of what EMT is and of the main EMT activating factors, the particularities of EMT in tumors and the molecular mechanisms that underlie the tumor EMT phenotypic plasticity are adressed. Finally, the contribution of EMT studies for the development of a new generation of cancer therapies is discussed.

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  1. Faculdade de Ciências da Universidade de Lisboa, Lisbon, Portugal

    Rita Zilhão

  2. Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal

    Hélia Neves

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Zilhão, R., Neves, H. (2019). Tumor Niche Disruption and Metastasis: The Role of Epithelial-Mesenchymal Transition (EMT). In: Fior, R., Zilhão, R. (eds) Molecular and Cell Biology of Cancer. Learning Materials in Biosciences. Springer, Cham. https://doi.org/10.1007/978-3-030-11812-9_9

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