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Monoclonal Gammopathies with Miscellaneous Associations
The list of diseases and syndromes eventually proving to be associated with monoclonal gammopathies, or paraproteinemias is progressively expanding.... -
Clinical characteristics and outcomes in risk-stratified patients with smoldering multiple myeloma: data from the Czech Republic Registry of Monoclonal Gammopathies
Smoldering multiple myeloma (SMM) is an asymptomatic precursor to active multiple myeloma (MM). The aim of this study was to report clinical...
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Gammopathies
Hypergammaglobulinemia results from a pathologically increased production of γ globulins, that can be either mono- or polyclonal. Monoclonal... -
Association of routine hematological parameters with the development of monoclonal gammopathies: a case-control study of 134,740 patients
The diagnosis of multiple myeloma requires detection of paraproteinemia and confirmation of monoclonal bone marrow infiltration, along with signs of...
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Gammopathies—Jewel in the Crown
In 1955 JW divorced Elisabet and in 1957 he remarried a research nurse from Uppsala. He moved into a nice house and would within 4 years be the... -
Elevated polyclonal IgG4 mimicking a monoclonal gammopathy in IgG4-related disease—a case-based review
IgG4-related diseases (IgG-RDs) are a group of fibroinflammatory diseases that affect a variety of tissues, resulting in tumour-like effects and/or...
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Immunophenotypic assessment of clonal plasma cells and B-cells in bone marrow and blood in the diagnostic classification of early stage monoclonal gammopathies: an iSTOPMM study
Monoclonal gammopathy of undetermined significance (MGUS) is the earliest discernible stage of multiple myeloma (MM) and Waldenström’s...
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New or Unusual Skin Manifestations in Monoclonal Gammopathies
Skin manifestations associated with monoclonal gammopathy (MG) are common and can present with various clinical and pathological aspects. They can be... -
Monoclonal gammopathy in the setting of Pyoderma gangrenosum
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis characterized by ulcerative painful lesions with violaceous undermined borders. Up to 75% of...
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Serum monoclonal immunoglobulin light-chain detection differs between immunofixation electrophoresis methods in patients with AL amyloidosis
Serum immunofixation electrophoresis (IFE) is often performed for screening monoclonal proteins (M proteins) in immunoglobulin light-chain...
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Polymyositis and Polyneuropathy Associated with IgGk Monoclonal Gammopathy in Long COVID
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an increased recognition of its potential to induce...
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Paraproteinemia Associated Myopathy
Monoclonal gammopathy refers to an increase in a single immunoglobulin class that may occur in association with normal or reduced levels of the other... -
Cutaneous manifestations of monoclonal gammopathy
Monoclonal gammopathy associated with dermatological manifestations are a well-recognized complication. These skin disorders can be associated with...
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Proliferative glomerulonephritis with monoclonal IgG Lambda deposits caused by plasmablastic lymphoma: a case report
IntroductionAs a very rare form of B-cell lymphoma, plasmablastic lymphoma (PBL) typically occurs in patients with underlying immunosuppression,...
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Successful use of lenalidomide to treat refractory acquired von Willebrand disease associated with monoclonal gammopathy
Acquired von Willebrand syndrome (AVWS) is a rare hematologic disorder characterized by quantitative or qualitative defects of von Willebrand factor...
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A case of proliferative glomerulonephritis with monoclonal IgG deposits (PGNMID) that responded favorably to steroid therapy
Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) generally has a poor prognosis and the consensus is that it needs...
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Gammopathies
Hypergammaglobulinemia results from a pathologically increased production of γ globulins, that can be either mono- or polyclonal. Monoclonal... -
Triclonal Gammopathy in Multiple Myeloma with Bleeding Diathesis: A Case Report
IntroductionGammopathies have clinical and diagnostic significance for lymphoproliferative disorders and plasma cell dyscrasias such as multiple...
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Protein Diagnostics
Protein diagnostics mainly deals with monoclonal gammopathies, conditions characterized by the presence of a monoclonal immunoglobulin (or part of... -
Long Term Remission of Capillary Leak Syndrome Associated with Monoclonal Gammopathy with Progression to Multiple Myeloma After Autologous Stem Cell Transplantation: a Case Report and Review of the Literature
BackgroundClarkson’s disease is a very rare entity characterised by acute episodes of systemic oedema and severe hypotension associated with...