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Clinical and therapeutic outcomes of pediatric pituitary adenomas: a single pituitary center experience
PurposePediatric pituitary adenomas (PPA) are rare. Although PPAs are mostly benign, they can be challenging to manage. Most studies evaluating PPA...
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Immunological signatures and predictive biomarkers for first-generation somatostatin receptor ligand resistance in Acromegaly
PurposePredicting resistance to first-generation Somatostatin Receptor Ligands (fg-SRL) in Acromegaly patients remains an ongong challenge....
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A prospective study on the efficacy of oral estrogen in female patients with acromegaly
PurposeTo evaluate the efficacy and safety of oral estrogen therapy in female patients of childbearing age with uncontrolled acromegaly and to verify...
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The learning curve for endoscopic endonasal pituitary surgery: a systematic review
Recent literature demonstrates that a learning curve exists for endoscopic pituitary surgery. However, there is significant variability in the way...
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Pituitary macroadenomas in childhood and adolescence: a clinical analysis of 7 patients
BackgroundPituitary adenomas (PPAs) are uncommon in childhood and adolescence, accounting for 2–6% of all intracranial neoplasms. Delayed puberty,...
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Malignant paraganglioma and somatotropinoma in a patient with germline SDHB mutation—genetic and clinical features
BackgroundPituitary adenomas and paragangliomas/pheocromocytomas are rare endocrine tumours, which can be sporadic or familial. During many years...
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Familial Endocrine Cancer Syndromes with Pediatric and Adolescent Presentation
Endocrine neoplasms presenting in younger patient populations tend to have familial, and rarely sporadic, inheritance. These pediatric-onset familial...
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Pediatric pituitary adenomas are more aggressive, more likely to be hormone producing and are more difficult to cure than adult pituitary adenomas: case series and systematic literature review
PurposePediatric pituitary adenomas (pPAs) are uncommon. Thus, their presentation and outcomes after treatment are less well-understood than those of...
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Identification and gene expression profiling of human gonadotrophic pituitary adenoma stem cells
BackgroundGonadotrophic pituitary adenoma is a major subtype of pituitary adenoma in the sellar region, but it is rarely involved in the...
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Genetics of Pituitary Gigantism: Syndromic and Nonsyndromic Causes
The last decades have seen an expansion of knowledge regarding GH-secreting pituitary adenomas in general and gigantism in particular. New...
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Equivalent outcomes in nasal symptoms following microscopic or endoscopic transsphenoidal surgery: results from multi-centre, prospective study
BackgroundT ranssphenoidal surgery (TSS) is the standard approach for resection of pituitary lesions. Historically, this has utilized the microscopic...
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Germline AIP variants in sporadic young acromegaly and pituitary gigantism: clinical and genetic insights from a Han Chinese cohort
PurposeVariants in the Aryl hydrocarbon receptor-interacting protein ( AIP ) gene have been identified in sporadic acromegaly and pituitary gigantism,...
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Acromegaly: Preconception Management
Family planning is an important component of the medical care for women with acromegaly. For women desiring fertility, preconception counseling...
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High prevalence of morphometric vertebral fractures opportunistically detected on thoracic radiograms in patients with non-functioning pituitary adenoma
PurposeVertebral fractures (VFs), the hallmark of skeletal fragility, have been reported as an emerging complication in patients with pituitary...
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Pituitary Disorders Affecting Linear Growth: Tall Stature
Growth hormone (GH) excess secondary to a pituitary adenoma may lead to gigantism in children and adolescents. Most pituitary tumors occur...