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Short tandem repeat mutations regulate gene expression in colorectal cancer
Short tandem repeat (STR) mutations are prevalent in colorectal cancer (CRC), especially in tumours with the microsatellite instability (MSI)...
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Diagnostic uplift through the implementation of short tandem repeat analysis using exome sequencing
To date, approximately 50 short tandem repeat (STR) disorders have been identified; yet, clinical laboratories rarely conduct STR analysis on exomes....
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Short Tandem Repeat Profile for Authentication of Immortal Murine Cancer Cell Line MH-22A
AbstractThe murine cell line MH-22A was originally established at least 50 years ago from a non-metastasizing tumor induced by 3-methylcholanthrene...
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Short Tandem Repeats Profiling
DNA is the blueprint of life, found in almost every living organism, and working as a set of instructions governing every aspect of the functioning...
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R-LOOPs on Short Tandem Repeat Expansion Disorders in Neurodegenerative Diseases
Expansions of short tandem repeats (STRs) have been found to be present in more than 50 diseases and have a close connection with neurodegenerative...
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Forensic short tandem repeat markers alteration in cancerous tissues: a sco** review
BackgroundShort Tandem Repeats (STRs) are segments of DNA composed of a short sequence of nucleotides that repeat consecutively. These repeating...
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Determination of allele frequencies in 15 autosomal short tandem repeat (STR) loci of Arab residents in Iraq
Recent advances in genetic research and molecular techniques have significantly contributed to our understanding of human population genetics and its...
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Establishment of a Novel Short Tandem Repeat Ty** Method for Exophiala dermatitidis
The opportunistic black yeast-like fungus Exophiala dermatitidis frequently colonizes the respiratory tract of cystic fibroses (CF) patients....
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Rediscovering tandem repeat variation in schizophrenia: challenges and opportunities
Tandem repeats (TRs) are prevalent throughout the genome, constituting at least 3% of the genome, and often highly polymorphic. The high mutation...
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Linked-read sequencing for detecting short tandem repeat expansions
Detection of short tandem repeat (STR) expansions with standard short-read sequencing is challenging due to the difficulty in map** multicopy...
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Forensic autosomal and gonosomal short tandem repeat marker reference database for populations in Burkina Faso
Tandem repeat genetic profiles used in forensic applications varies between populations. Despite the diversity and security issues in the Sahel that...
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Short tandem repeat analysis: a practical tool to identify specimen mix-ups in the pathology laboratory
Despite all precautions in pathology laboratories, contaminations and specimen mix-ups still occur and can negatively impact both patients and...
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Short Tandem Repeat Mutations in Paternity Analysis
Polymorphic autosomal short tandem repeats (STRs) are a class of genetic markers that are routinely being used for parentage testing purposes in...
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LUSTR: a new customizable tool for calling genome-wide germline and somatic short tandem repeat variants
BackgroundShort tandem repeats (STRs) are widely distributed across the human genome and are associated with numerous neurological disorders....
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De novo design of knotted tandem repeat proteins
De novo protein design methods can create proteins with folds not yet seen in nature. These methods largely focus on optimizing the compatibility...
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Detecting Tandem Repeat Expansions Using Short-Read Sequencing for Clinical Use
Repeat expansion disorders are a unique class of genetic diseases caused by expansions of short tandem repeats. Until recently, these pathogenic...
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Analysis of Tandem Repeat Expansions Using Long DNA Reads
Abnormal expansion or shortening of tandem repeats can cause a variety of genetic diseases. The use of long DNA reads has facilitated the analysis of...
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Sequence composition changes in short tandem repeats: heterogeneity, detection, mechanisms and clinical implications
Short tandem repeats (STRs) are a class of repetitive elements, composed of tandem arrays of 1–6 base pair sequence motifs, that comprise a...
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Sequencing and characterizing short tandem repeats in the human genome
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human genome that are composed of repeated copies of a 1–6-bp motif. Over...
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RExPRT: a machine learning tool to predict pathogenicity of tandem repeat loci
Expansions of tandem repeats (TRs) cause approximately 60 monogenic diseases. We expect that the discovery of additional pathogenic repeat expansions...
