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High-throughput reprogramming of an NRPS condensation domain
Engineered biosynthetic assembly lines could revolutionize the sustainable production of bioactive natural product analogs. Although yeast display is...
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Non-ribosomal peptide synthetase (NRPS)-encoding products and their biosynthetic logics in Fusarium
Fungal non-ribosomal peptide synthetase (NRPS)-encoding products play a paramount role in new drug discovery. Fusarium , one of the most common...
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NRPS and PKS Gene Analysis in Cyanobacteria Using PCR
Cyanobacteria are ancient prokaryotes with the capacity to perform oxygenic photosynthesis and can be found in a great diversity of habitats,...
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A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin
Biosynthesis of the flavonoid naringenin in plants and bacteria is commonly catalysed by a type III polyketide synthase (PKS) using one p -coumaroyl-Co...
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Siderophore-synthesizing NRPS reprogram lipid metabolic profiles for phenotype and function changes of Arthrobotrys oligospora
The objective of this paper is to explore the function of the AOL-s00215g415 ( Aog415 ) gene, which encodes for the synthesis of siderophore in the...
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Nonribosomal peptide synthetase gene clusters and characteristics of predicted NRPS-dependent siderophore synthetases in Armillaria and other species in the Physalacriaceae
Fungal secondary metabolites are often pathogenicity or virulence factors synthesized by genes contained in secondary metabolite gene clusters...
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Nonribosomally and Ribosomally Synthesized Bioactive Peptides (NRPS and RiPPs) from Actinobacteria
From time immemorial, natural products (NPs) are a major source of drugs in the pharmaceutical industry ranging from antibiotics, anti-depressants,...
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Mining and characterization of the PKS–NRPS hybrid for epicoccamide A: a mannosylated tetramate derivative from Epicoccum sp. CPCC 400996
BackgroundGenomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have...
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Mining for NRPS and PKS Genes in Actinobacteria Using Whole-Genome Sequencing and Bioinformatic Tools
Antimicrobial resistance of pathogens against known antibiotics is a growing concern. It is a call of emergency to find an effective cure for...
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Recent Advances in Re-engineering Modular PKS and NRPS Assembly Lines
Polyketides such as the antibiotic erythromycin or the immunosuppressant rapamycin, and non-ribosomal peptides, such as the antibiotics penicillin or...
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NMR resonance assignments for a docking domain pair with an attached thiolation domain from the PAX peptide-producing NRPS from Xenorhabdus cabanillasii
Non-ribosomal peptide synthetases (NRPSs) are large multienzyme machineries. They synthesize numerous important natural products starting from amino...
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Characterization of NRPS and PKS genes involved in the biosynthesis of SMs in Alternaria dauci including the phytotoxic polyketide aldaulactone
Alternaria dauci is a Dothideomycete fungus, causal agent of carrot leaf blight. As a member of the Alternaria genus, known to produce a lot of...
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Do the New Rural Pension Scheme promote the health status of chronic patients in old age? —Evidence from CHARLS 2018 in China
BackgroundMany researchers have examined the impact of social insurance on health in elderly. However, in most cases, they have only demonstrated...
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Genus level analysis of PKS-NRPS and NRPS-PKS hybrids reveals their origin in Aspergilli
BackgroundFilamentous fungi produce a vast amount of bioactive secondary metabolites (SMs) synthesized by e.g. hybrid polyketide...
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Impact of pension income on healthcare utilization of older adults in rural China
ObjectiveIn China, rural residents experience poorer health conditions and a higher disease burden compared to urban residents but have lower...
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Mining metagenomes reveals diverse antibiotic biosynthetic genes in uncultured microbial communities
Pathogens resistant to antimicrobials form a significant threat to public health worldwide. Tackling multidrug-resistant pathogens via screening...
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Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides
The modular nature of nonribosomal peptide biosynthesis has driven efforts to generate peptide analogs by substituting amino acid-specifying domains...
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Mutagenetic analysis of the biosynthetic pathway of tetramate bripiodionen bearing 3-(2H-pyran-2-ylidene)pyrrolidine-2,4-dione skeleton
BackgroundNatural tetramates are a family of hybrid polyketides bearing tetramic acid (pyrrolidine-2,4-dione) moiety exhibiting a broad range of...
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Structural Studies of Modular Nonribosomal Peptide Synthetases
The non-ribosomal peptide synthetases (NRPSs) are a family of modular enzymes involved in the production of peptide natural products. Not restricted...
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Non-magnetic four-port electronic circulators based on \(90^\circ \) non-reciprocal phase-shifters
This paper presents a family of four-port electronic circulators adhering to a new topology symmetry that enables linear, low-loss transistor-based...
