Abstract
From time immemorial, natural products (NPs) are a major source of drugs in the pharmaceutical industry ranging from antibiotics, anti-depressants, anti-inflammatory, anti-tumor, and anti-cancer agents to name a few. Actinobacteria and their biosynthetic pathways contribute substantially to these drugs present in the laboratory level, clinical phase trials, and in the market. The majority of the secondary metabolites secreted are produced from the nonribosomal peptide synthetase (NRPS) and polyketide synthetase (PKS) enzymes. Apart from the nonribosomal peptides produced, ribosomally produced peptides that undergo drastic post-translational modifications also play a part in contributing to the essential drugs produced. The chapter deals with both nonribosomal peptides (NRPs) and ribosomally synthesized and post-translationally modified peptides (RiPPs).
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Neethu, K., Karthik, L., Li, Z. (2022). Nonribosomally and Ribosomally Synthesized Bioactive Peptides (NRPS and RiPPs) from Actinobacteria. In: Karthik, L. (eds) Actinobacteria. Springer, Singapore. https://doi.org/10.1007/978-981-16-5835-8_5
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