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Molecular Markers for Mutant Characterization
Mutants are either obtained spontaneously or artificially induced frequently in various organisms to serve several purposes like expanding the...
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Identification of Induced Copy Number Variation from Low Coverage Sequence Data
Induced mutations have been an important tool for plant breeding and functional genomics for more than 80 years. Novel mutations can be induced by...
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Optimal sequence of LT for symptomatic BM in EGFR-mutant NSCLC: a comparative study of first-line EGFR-TKIs with/without upfront LT
BackgroundThe third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) can penetrate blood–brain barrier and are...
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Sequence-dependent synergistic effect of aumolertinib-pemetrexed combined therapy on EGFR-mutant non-small-cell lung carcinoma with pre-clinical and clinical evidence
BackgroundInevitably developed resistance of the third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) limited...
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The role of triple therapy and therapy sequence in treatment of BRAF-mutant metastatic melanoma. Response to overall survival with first-line atezolizumab in combination with vemurafenib and cobimetinib in BRAFV600 mutation-positive advanced melanoma (IMspire150): second interim analysis of a multicentre, randomised, phase 3 study
Novel therapies have achieved unprecedented benefit in survival of advanced melanoma patients. While immunotherapy (ICI) can be administered...
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Computational Random Mutagenesis to Investigate RAS Mutant Signaling
This chapter describes how mathematical models can be used to investigate the possible range of behaviors for mutant forms of a protein. A...
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Peptide Engineering Approach to Introduce an Improved Calcitonin Mutant
AbstractCalcitonin is a 32-amino acid peptide, which causes a decrease in blood calcium levels and bone resorption in the human body. It is produced...
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Intellectual Property Over Mutant and Gene Edited Plants
Intellectual property rights can cover biological inventions including plants, plant varieties, and plant parts. Defining stable boundaries for plant...
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A pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer...
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Characteristics of a radish mutant with longer siliques
The silique is an important organ in plant reproduction and maintains biodiversity among species; however, little is known about the regulation of...
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Improving the Catalytic Properties of Xylanase from Alteromones Macleadii H35 Through Sequence Analysis
Endo-1,4-β-xylanase is a key xylanolytic enzyme, and our study aimed to enhance the catalytic properties of Alteromones Macleadii xylanase (Xyn ZT-2)...
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Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis
Whether TMPRSS2-ERG fusion and TP53 gene alteration coordinately promote prostate cancer (PCa) remains unclear. Here we demonstrate that TMPRSS2-ERG ...
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Design and Self Assembly of Tri-Terpene Peptide Conjugates and Their Interactions with EGFR and EGFR Mutant Receptors: An In Silico and In Vitro Study
In this work, we designed new terpenoid-peptide conjugates to target the epidermal growth factor receptor (EGFR) and its double mutant EGFR...
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Characterization and fine map** of a white stripe leaf mutant in rice
Leaf color affects the efficiency of photosynthesis, and leaf color mutants are important genetic materials for studying the mechanisms of...
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Genomic profiles of IDH-mutant gliomas: MYCN-amplified IDH-mutant astrocytoma had the worst prognosis
This study aimed to find any ambiguous genetic outlier for “oligodendroglioma, IDH-mutant and 1p/19q-codeleted (O_IDH_mut)” and “astrocytoma,...
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Digital PCR: a tool in clostridial mutant selection and detection
AbstractThe ClosTron mutagenesis system has enabled researchers to efficiently edit the clostridial genome. Since site-specific insertion of the...
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Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3
PurposeTargeted therapies have markedly improved the prognosis of lung cancer patients; nevertheless, challenges persist, including limited...
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1H, 15N and13C resonance assignments of S2A mutant of human carbonic anhydrase II
In preparation for a detailed exploration of the structural and functional aspects of the Ser2Ala mutant of human carbonic anhydrase II, we present...
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Derived Polymorphic Amplified Cleaved Sequence (dPACS) Assay
The derived polymorphic amplified cleaved sequence (dPACS) assay is a simple polymerase chain reaction/restriction fragment length polymorphism...